Busath, David

Physiology & Developmental Biology

Email: 9MjrmhK~|j}qIk‚~7nm~  (Email Form)

Website: http://busathlab.byu.edu

3019  LSB
Provo, UT 84602
(801) 422-8753

Professor

Curriculum Vitae

 Biography
Born and raised in Salt Lake City, Utah. Bachelors and medical training at the University of Utah. Postdoctoral fellowships at Rochester, NY and Galveston, TX. Early faculty career at Brown University. Transferred to Brigham Young University in 1995.
 Teaching Interests
Human anatomy, physiology, and biophysics
 Research Interests
Ion channel biophysics, influenza virus, volatile anesthetics, botulinum toxin, gramicidin channels
 Experience

Professional
  • Adjunct Professor Research, Touro University Nevada, 2011-2013

 Memberships
  • International Society for Antiviral Research, 2012-Present
  • Antiviral Society, 2011-Present
  • Neuroscience Center, 1999-Present
  • Biophysical Society, 1978-Present
  • American Chemical Society, 2005-2012
 Honors and Awards
  • College of Life Sciences, BYU : Outstanding Research Award
  • Department of Physiology and Dev. Biol. : Outstanding Achievement and Service Award
  • BYU : Thomas Martin Professorship
  • BYU : Alcuin Fellowship for General Education Teaching
  • College of Biology and Agriculture : Research Award
  • Brown University : Research Career Development Award
  • Mount Dessert Island Biological Laboratory : Markey Fellow
 Courses Taught

Spring 2017
  • PDBIO 494R: Undergraduate Research Section 005
Winter 2017
  • NEURO 449R: Neuro Research Experience Section 004
  • PDBIO 362: Advanced Physiology Section 001
  • PDBIO 494R: Undergraduate Research Section 005
  • PDBIO 495R: Adv Undgraduate Research Section 005
  • PDBIO 799R: Dissertation Section 005
Fall 2016
  • NEURO 449R: Neuro Research Experience Section 003
  • PDBIO 220: Human Anatomy (with lab) Section 001
  • PDBIO 494R: Undergraduate Research Section 005
  • PDBIO 495R: Adv Undgraduate Research Section 005
  • PDBIO 568: Biophysics Section 001
  • PDBIO 799R: Dissertation Section 013
Summer 2016
  • PDBIO 494R: Undergraduate Research Section 005
  • PDBIO 649R: Laboratory Research Section 005

Selected Publications

Journal Articles

Gleed ML, Ioannidis H, Kolocouris A, Busath DD. 2015. Resistance-Mutation (N31) Effects on Drug Orientation and Channel Hydration in Amantadine-Bound Influenza A M2. Journal of Physical Chemistry B. 119:11548-11559.  doi:10.1021/acs.jpcb.5b05808

Durrant MG, Eggett DL, Busath DD. 2015. Investigation of a recent rise of dual amantadineresistance mutations in the influenza A M2 sequence. BMC Genetics. 16(Suppl 2):S3. <website> doi:10.1186/1471-2156-16-S2-S3

Gleed ML, Busath DD. 2014. Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N). Journal of Physical Chemistry B. 119(3):1225-1231.  doi:dx.doi.org/10/1021/jp508545d

Kolocouris A, Tzitzoglaki C, Johnson B, Zell R, Wright A, Cross TA, Tietjen I, Fedida D, Busath DD. 2014. Adamantanes with persistent in vitro efficacy against H1N1 (2009) Influenza A. Journal of Medicinal Chemistry. 57:4629-4639.

Cross TA, Dong H, Sharma M, Busath D, Zhou H. 2012. M2 Protein from Influenza A: From multiple structures to biophysical and functional insights. Current Opinions Virology. 2:128-133.

Nelson SC, Neely SK, Melonakos ED, Bell JD, Busath D. 2012. Fluorescence anisotropy of diphenylhexatriene and its cationic trimethylamino derivative in liquid dipalmitoylphosphatidylcholine liposomes: Opposing responses to isoflurane. BMC Biophysics. 5:5.

Mellor BL, Khadka S, Busath D, Mazzeo BA. 2011. Influence of pKa shifts on the calculated dipole moments of proteins. The Protein Journal. 30:490-498.

Separovic F, Killian JA, Cotten M, Busath D, Cross TA. 2011. Modeling the membrane environment for membrane proteins. Biophysical Journal. 100:2073-2074.

Sharma M, Li C, Busath D, -X. Zhou H, Cross. TA. 2011. Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins. Biochim. et Biophys. Acta., Biomembranes. 1808:516-521.

Peterson E, Ryser T, Funk S, Inouye D, Sharma M, Qin H, Cross TA, Busath D. 2011. Functional reconstitution of influenza A M2(22-62). 1808:516-521.

Mellor BL, Cruz Cortes E, Busath D, Mazzeo BA. 2011. Method for Estimating the Internal Permittivity of Proteins Using Dielectric Spectroscopy. Journal of Physical Chemistry B. 115(10):2205-2213. <website>

Sharma M, Yi M, Hao D, Qin H, Peterson E, Busath D, Zhou H, Cross TA. 2010. Insights into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science. 330:509-512.

Jones TL, Fu R, Nielson F, Cross TA, Busath D. 2010. Gramicidin channels are internally gated. Biophysical Journal. 98:1486-1493.

Mustafa MA, Henderson D, Busath D. 2009. Free-energy profiles for ions in the influenza M2-TMD channel. Proteins. 76:794-807.

Mustafa M, Henderson D, Busath D. 2009. Computational studies of gramicidin permeation: An entryway sulfonate enhances cation occupancy at entry sites. Biochim. Biophys. Acta. 1788:1404-1412. <website>

Spohr E, Sovyak E, Trokhymchuk A, Busath D. 2009. Electrostatic control of occupancy and valence selectivity in a charged nanometer-sized cylindrical pore. Materialwissenschaft und Werkstofftechnik. 40:247-254.

Miller CE, Busath D, Strongin B, Majewski J. 2008. Integration of Ganglioside GT1b Receptor into DPPE and DPPC Phospholipid Monolayers: An X-ray Reflectivity and Grazing Incidence Diffraction Study. Biophysical Journal. 95:3278-3286.

Moffat JC, Vijayvergiya V, Gao PF, Cross TA, Woodbury DJ, Busath D. 2008. Proton transport through influenza A virus M2 protein reconstituted in vesicles. Biophysical Journal. 94:434-445. <website>

Durrant JD, Caywood D, Busath D. 2006. Tryptophan contributions to the empirical free-energy profile in gramicidin A/M heterodimer channels. Biophysical Journal. 91:3230-3241.

Other

Busath D, Woodbury DJ, Frost A. 2012. Endosis and exosis: New names for fusion and budding. <website>

Presentations

McGuire KL, Wallentine SK, Nathan GA, Mohl GA, Jensen MD, Harrison RG, Busath D. Divalent Copper Complexes as Influenza a M2 S31N Blockers. 60th Biophysical Society Meeting. Los Angeles, CA. 2016 .

McGuire KL, Gleed ML, Busath D. Observation of Partial and Complete Block by Amantadine and Rimantadine in Influenza A M2 S31N by Electrophysiology Methods. 60th Biophysical Society Meeting. Los Angeles, CA. 2016 .

Bodily TA, Peacock JB, Busath D. Comparative Efficacies of Transcutaneous Electrical Nerve Stimulation Protocols in Peripheral Neuropathy Subjects. Utah Conference for Undergraduate Education. BYU. 2016 .

Mohl GA, Jensen MD, Wallentine SK, McGuire KL, Harrison RG, Busath D. Preparing for the Emergence of a Highly Pathogenic Influenza Pandemic. Utah Conference for Undergraduate Education. University of Utah. 2016 .

Bodily TA, Peacock JB, Busath D. Comparative Efficacies of Transcutaneous Electrical Nerve Stimulation Protocols in Peripheral Neuropathy Subjects. Neuroscience Poster Showcase. BYU. 2015 .

Bodily TA, Peacock JB, Busath D. Comparative Efficacies of Transcutaneous Electrical Nerve Stimulation Protocols in Peripheral Neuropathy Subjects. Snowbird Neuroscience Symposium. Snowbird, UT. 2015 .

Bodily TA, Peacock JB, Busath D. Comparative Efficacies of Transcutaneous Electrical Nerve Stimulation Protocols in Peripheral Neuropathy Subjects. Society for Neuroscience Meeting. Chicago, IL. 2015 .

Larsen J, Grooms M, Ashton BG, Busath D. HOW NSAIDS AFFECT LIPID MONOLAYER AND BILAYER PROPERTIES. Biophysical Society 59th Annual Meeting. Baltimore, MD. 2015 .

Tietjen I, Miller SC, Boycott HE, Eldstrom J, Kwan DC, Chou D, Jalily P, Menconda D, Johnson FB, Schmidtke M, et al. Discovery of novel acylguanidine-based small molecules that block Influenza A M2 ion channel activity and drug-resistant virus. International Conference on Antiviral Research. Raleigh, NC. 2014 .

Kolocouris A, Johnson FB, Zell R, Schmidtke M, Sureda FX, Cross TA, Fedida D, Tzitzoglaki C, Ioannidis H, Hoffman A, et al. INFLUENZA A BLOCKERS WITH REDUCED RESISTANCE FORMATION. Biophysical Society 58th Annual Meeting. San Francisco, CA. 2014 .

Busath D. Persistent Blockers for Modern Influenza A. PDBio Seminar. Provo. 2013 .

Kolocouris A, Johnson FB, Zell R, Wright AK, Tzitzoglaki C, Ioannidis H, Schmidtke M, López-Querol M, Cross TA, Childs R, et al. AMANTADINE ANALOGS THAT INHIBIT MDCK CELL INFECTION BY H1N1 2009 INFLUENZA A CONTAINING M2(S31N). Ion Channel Retreat 2013. Vancouver, CA. 2013 .

Kolocouris A, Johnson FB, Tzitzoglaki C, Sureda FX, Anderson T, Wright AK, Cross TA, Busath D. Amantadine Analogs that Inhibit MDCK Cell Infection by H1N1 2009 Influenza A Containing M2(S31N). International Conference on Antiviral Research. San Francisco, CA. 2013 .

Kolocouris A, Johnson FB, Tzitzoglaki C, Sureda FX, Anderson T, Wright AK, Cross TA, Busath D. Amantadine Analogs that Inhibit MDCK Cell Infection by H1N1 2009 Influenza A Containing M2(S31N). William DeGrado Lab Meeting. San Francisco, CA. 2013 .

Kolocouris A, Johnson B, Tzitzoglaki C, Gay NC, Busath D. AMANTADINE ANALOGS THAT INHIBIT MDCK CELL INFECTION BY INFLUENZA A WITH M2(S31N). Biophysical Society 57th Annual Meeting. Philadelphia, PA. 2013 .

Fowler MR, Busath D. SIMULATIONS OF THE PHASE TRANSITION OF DPPC BILAYER WITH AND WITHOUT DPH OR TMA-DPH USING CHARMM36. Biophysical Society 57th Annual Meeting. Philadelphia, PA. 2013 .

Busath D. Can we Stop Pandemic Flu with an Anti-viral Drug?. Current Topics in Molecular Life Sciences Seminar. Provo, UT. 2011 .

Busath D. Influenza A M2 is a Drug Target. Ion Channel Workshop. Vancouver, BC, Canada. 2011 .

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