Thomson, David

Physiology & Developmental Biology

Email: 6jg|ojeznusyutFh{4kj{  (Email Form)

3013  LSB
Provo, UT 84602
(801) 422-8709

Associate Professor

Curriculum Vitae

 Research Interests
The primary research focus of my lab is the effect of old-age and diabetes on skeletal muscle metabolism, mass and function. Understanding the mechanisms that control muscle mass is important in understanding and developing behavioral and pharmacological treatments for many conditions where muscle mass is compromised, including aging, muscle injury, diabetes, and so forth. We are particularly interested in the molecular signaling pathways [e.g. AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR)] that are important in the control of muscle growth, and how those pathways are affected by various stimuli such as exercise, inflammation, diet, obesity and inactivity.
 Courses Taught

Fall 2016
  • NEURO 694R: Research Presentation Section 001
  • PDBIO 305: Human Physiology Section 001, 004
  • PDBIO 494R: Undergraduate Research Section 017
  • PDBIO 495R: Adv Undgraduate Research Section 017
  • PDBIO 550R: Advanced Topics Section 018
  • PDBIO 601: Cell & Molecular Physiology Section 001
  • PDBIO 694R: Research Presentation Section 001
  • PDBIO 799R: Dissertation Section 011
Summer 2016
  • PDBIO 494R: Undergraduate Research Section 018
  • PDBIO 495R: Adv Undgraduate Research Section 018
Spring 2016
  • PDBIO 494R: Undergraduate Research Section 018
  • PDBIO 495R: Adv Undgraduate Research Section 018
Winter 2016
  • NEURO 694R: Research Presentation Section 001
  • PDBIO 494R: Undergraduate Research Section 017
  • PDBIO 495R: Adv Undgraduate Research Section 017
  • PDBIO 550R: Advanced Topics Section 018
  • PDBIO 565: Endocrinology Section 001
  • PDBIO 694R: Research Presentation Section 001
  • PDBIO 799R: Dissertation Section 014

Selected Publications

Journal Articles

Hardman SE, Hall DE, Cabrera AJ, Hancock CR, Thomson DM. 2014. The effects of age and muscle contraction on AMPK activity and heterotrimer composition. Experimental Gerontology. 55:120-128.

Henriksen BS, Curtis ME, Fillmore N, Cardon BR, Thomson DM, Hancock CR. 2013. The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding. Diabetology & Metabolic Syndrome. 5(1).  doi:10.1186/1758-5996-5-29

Jackson KC, Wohlers LM, Lovering RM, Schuh RA, Maher AC, Bonen A, Koves TR, Ilkayeva O, Thomson DM, Muoio DM, et al. 2012. Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice. Am J Physiol Regul Integr Comp Physiol.

Merrill JF, Thomson DM, Hardman SE, Hepworth SD, Willie S, Hancock CR. 2012. Iron deficiency causes a shift in AMP-activated protein kinase (AMPK) subunit composition in rat skeletal muscle. Nutr Metab. 9(1).

Frier BC, Hancock CR, Little JP, Fillmore N, Bliss TA, Thomson DM, Wan Z, Wright DC. 2011. Reductions in RIP140 are not required for exercie- and AICAR-mediated increases in skeletal muscle mitochondrial content. Journal of Applied Physiology. 111(3):688-695.

Brown JD, Hancock CR, Mongillo AD, Barton BJ, Digiovanni RA, Parcell AC, Winder WW, Thomson DM. 2011. Effect of LKB1 deficiency on mitochondrial content, fiber type, and muscle performance in the mouse diaphragm. Acta Physiologica. 201(4):457-466.

Thomson DM, Hancock CR, Evanson BG, Kenney SG, Mallan BB, Mongillo AD, Brown JD, Hepworth S, Fillmore N, Parcell AC, et al. 2010. Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice. J Appl Physiol. 108:1775-1785.

Presentations

Hardman SE, Merrill JF, Thomson DM, Hancock CR. The effect of iron deficiency on AMPK subunit isoform composition in skeletal muscle. Experimental Biology. Boston, MA. 2013 .

Madsen SR, Rindlisbach CA, Bradshaw JM, Moore TM, Hallowell DM, Thomson DM. Contraction induced gene expression changes in skeletal muscle-specific LKB1 knockout mice. Integrative Biology of Exercise. Denver, CO. 2012 .

Jacobs MB, Hardman SE, Moore TM, Lew J, Reynolds PR, Thomson DM. RAGE and STAT3 signaling in chronic AICAR-treated young adult and old skeletal muscle. Integrative Biology of Exercise. Denver, CO. 2012 .

Anderson SK, Hardman SE, Nelson BJ, Oleskey ZP, Thomson DM. Role of LKB1 in skeletal muscle regeneration after injury. integrative Biology of Exercise. Denver, CO. 2012 .

Hallowell DM, Tanner CB, Nuttall MR, Anderson SK, Bradshaw JM, Madsen SR, Thomson DM. Exercise training-induced mitochondrial biogenesis is impaired in skeletal muscle-specific LKB1 knockout mice. Experimental Biology. San Diego, CA. 2012 .

Merrill JF, Hepworth SD, Willie S, Winder WW, Thomson DM, Hancock CR. Iron deficiency causes a shift in AMP-activated protein kinase (AMPK) catalytic subunit composition in rat skeletal muscle. Experimental Biology. San Diego, CA. 2012 .

Hardman SE, Hall DE, Mitchell AJ, Black KM, Compton RA, Thomson DM. The effects of aging and muscle contraction on AMPK activity. Experimental Biology. San Diego, CA. 2012 .

Hall DE, Hardman SE, Jacobs MB, Mitchell AJ, Thomson DM. The effects of aging on AMPK subunit expression and complex formation. Experimental Biology. San Diego, CA. 2012 .

Curtis M, Henriksen B, Fillmore N, Winder WW, Thomson DM, Hancock CR. Chronic activation of AMPK limits hepatic triglyceride accumulation independent of changes in total glycerol-3-phosphate-acyltransferase activity. Experimental Biology. Washington, DC. 2011 .

Thomson DM, Hancock CR, Evanson BG, Kenney SG, Malan BB, Mongillo AD, Brown JD, Hepworth S, Fillmore N, Parcell AC, et al. Muscle-specific LKB1 knockout leads to skeletal muscle dysfunction. FASEB Summer Research Conference- AMPK:Central Regulatory System in Metacolism & Growth. Kyoto, Japan. 2010 .

Flint C, Brown JD, Malan BB, Tenney T, Oleskey Z, Thomson DM. Increased Inflammatory Response to Overload in Skeletal Muscle Lacking LKB1. Integrative Physiology of Exercise. Miami, FL. 2010 .

Platt SP, Nelson CA, Thomson DM. Increased voluntary running in PAS kinase-knockout mice. Integrative Physiology of Exercise. Miami, FL. 2010 .

Yokoyama K, Brown JD, Thomson DM. The effects of exercise on progesterone receptor phosphorylation in skeletal muscle. Integrative Physiology of Exercise. Miami, FL. 2010 .

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