Edwards, Jeff

Physiology & Developmental Biology

Email: 2lghhtg{agfyctfuBd{w0gfw  (Email Form)

Website: http://edwardslab.byu.edu

3046  LSB
Provo, UT 84602
(801) 422-8080

Associate Professor

Curriculum Vitae

 Research Interests
Learning and Memory as well as Reward/Addiction pathways- Using electrophysiology in combination with pharmacology and molecular biology techniques the lab studies synaptic plasticity, the cellular mechanism allowing our brains to learn and adapt. We study synaptic plasticity in the hippocampus, the primary region involved in learning and memory and the ventral tegmental area, which is the reward pathway of the brain. The goal is to understand normal brain function and as a result apply this to abnormal states such as epilepsy and Alzheimer’s in the hippocampus and addiction in the ventral tegmental area.
 Administrative Positions
Associate Director
Associate Director of the Brigham Young University Neuroscience Center.
Responsibilities inclu .... more
 Experience

Academic - Post-Secondary
  • Associate Director, BYU Neuroscience Center, 2015-Present
  • Associate Professor, Brigham Young University, 2013-Present
  • Faculty, BYU Neuroscience Center, 2007-Present

Professional
  • President, Society for Neuroscience Intermountain Branch, 2012-Present

 Memberships
  • International Cannabinoid Research Society, 2012-Present
  • American Association for the Advancement of Science, 2007-Present
  • Neuroscience Center, 2007-Present
  • Society for Neuroscience, 2004-Present
  • Intermountain Chapter Society for Neuroscience, 2000-Present
  • American Physiological Society, 1998-2007
  • Idaho Academy of Sciences, 2005-2006
  • Association for Chemoreception Sciences, 1999-2004
 Honors and Awards
  • PDBio : PDBio Award for Outstanding Achievement and Service
  • Faculty for Undergraduate Neuroscience : Honors Award
  • Faculty for Undergraduate Neuroscience : Honors Award
  • Brigham Young University : Graduate Mentoring Award
  • Faculty for Undergraduate Neuroscience : Honors Award
  • Faculty Center : Course Development Project Grant
  • BYU-Idaho : Thomas E. Ricks Award
  • NIH : National Service Research Award- Postdoctoral Fellowship
  • Association for Chemoreception Sciences : Don Tucker Memorial Award Nominee
  • Assocation for Chemoreception Sciences : Assocation for Chemoreception Sciences Travel Awards
  • Association for Chemoreception Sciences : Don Tucker Memorial Award Nominee
  • Intermountain Chapter Society for Neuroscience : Most outstanding presentation
 Courses Taught

Fall 2016
  • NEURO 449R: Neuro Research Experience Section 005
  • NEURO 799R: Doctoral Dissertation Section 007
  • PDBIO 495R: Adv Undgraduate Research Section 006
  • PDBIO 568: Biophysics Section 001
  • PDBIO 601: Cell & Molecular Physiology Section 001
  • PDBIO 649R: Laboratory Research Section 006
  • PDBIO 799R: Dissertation Section 005
Summer 2016
  • NEURO 799R: Doctoral Dissertation Section 003
  • PDBIO 799R: Dissertation Section 003
Spring 2016
  • NEURO 799R: Doctoral Dissertation Section 003
  • PDBIO 799R: Dissertation Section 004
Winter 2016
  • NEURO 449R: Neuro Research Experience Section 006
  • NEURO 649R: Laboratory Research Section 002
  • NEURO 799R: Doctoral Dissertation Section 005
  • PDBIO 305: Human Physiology (with lab) Section 005
  • PDBIO 362: Advanced Physiology Section 002
  • PDBIO 494R: Undergraduate Research Section 006
  • PDBIO 495R: Adv Undgraduate Research Section 006
  • PDBIO 689R: Practicum LfSci Tchg or Resrch Section 001
  • PDBIO 799R: Dissertation Section 006

Selected Publications

Journal Articles

Cordner RD, Friend LN, Mayo JL, Badgley C, Wallman A, Stallings CN, Young PL, Miles DR, Edwards JG, Bridgewater LC. 2017. The BMP2 nuclear variant, nBMP2, is expressed in mouse hippocampus and impacts memory. Scientific Reports.

Merrill CB, Friend LN, Newton ST, Hopkins ZH, Edwards JG. 2015. Ventral tegmental area dopamine and GABA neurons: Physiological properties and expression of mRNA for endocannabinoid biosynthetic elements. 5:16176. <website> doi:10.1038/srep16176

Taylor DH, Burman PN, Hansen DM, Wilcox RS, Larsen BR, Blanchard JK, Merrill CB, Edwards JG, Sudweeks SN, Wu J, et al. 2013. Nicotine enhances the excitability of GABA neurons in the ventral tegmental area via activation of alpha 7 nicotinic receptors on glutamate terminals. Biochemistry and Pharmacology. ePub ahead of print. <website>

Merrill C, McNeil M, Williamson R, Poole B, Nelson B, Sudweeks SN, Edwards JG. 2012. Identification of mRNA for endocannabinoid biosynthetic enzymes within hippocampal pyramidal cells and CA1 stratum radiatum interneuron subtypes using quantitative real-time polymerase chain reaction. Neuroscience. 218:88-99. <website>

Jensen T, Edwards JG. 2012. Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons. Neuroscience Letters. 510(2):82-87. <website>

Bennion D, Jensen T, Wallther C, Hamblin J, Wallmann A, Couch J, Blickenstaff J, Castle M, Dean L, Beckstead S, et al. 2011. Transient Receptor Potential Vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system. Neuropharmacology. 61(4):730-738. <website>

Steffensen SC, Bradley K, Hansen DM, Wilcox JD, Wilcox RS, Allison DW, Merrill CB, Edwards JG. 2010. The role of connexin-36 gap junctions in alcohol intoxication and consumption. Synapse. 65(8):695-707. <website>

Edwards JG, Gibson H, Jensen T, Nugent F, Walther C, Blickenstaff J, Kauer J. 2010. A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons. Hippocampus. DOI: 10.1002/hipo.20884. <website>

Wang Z, Edwards JG, Riley N, Provance DW, Karcher R, Li XD, Davison IG, Ikebe M, Mercer JA, Kauer JA, et al. 2008. Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Cell. 135:535-548. <website>

Gibson HE, Edwards JG, Page RS, Van Hook MJ, Kauer JA. 2008. TRPV1 Channels Mediate Long-Term Depression at Synapses on Hippocampal Interneurons. Neuron. 57:746-759. <website>

Park M, Penick EC, Edwards JG, Kauer JA, Ehlers MD. 2004. Recycling Endosomes Supply AMPA Receptors for LTP. Science. 305:1972-1975. <website>

Edwards JG, Michel WC. 2003. Pharmacological characterization of ionotropic glutamate receptors within the zebrafish olfactory bulb. Neuroscience. 122:1037-1047. <website>

Book Chapter

Edwards JG. 2014. TRPV1 in the Central Nervous System: Synaptic Plasticity, Function, and Pharmacological Implications. Omar M.E., editor. Progress in Drug Research: Capsaicin as a Therapeutic Molecule. VIIIth ed. vol. 68 p. 321

Presentations

Mayo JL, Nichols BA, Olsen DS, Cordner RD, Hancock CR, Weber KS, Wilson E, Edwards JG, Barrow JR, Bridgewater LC. The nBMP2 mutant mouse shows defects in intracellular calcium transport-regulated pathways. Southwest Regional Meeting of the Society for Developmental Biology. Aurora, Colorado. 2014 .

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