Alder, Jonathan

Physiology & Developmental Biology

Email: 9sxwj}qjwhjumn{Ik‚~7nm~  (Email Form)

3015  LSB
Provo, UT 84602
(801) 422-5714

Assistant Professor

Curriculum Vitae

 Research Interests
My laboratory is interested broadly in how telomeres contribute to human health and disease. Telomeres are perhaps the best-characterized biologic clock and telomere shortening is a universal feature of aging. As such, understanding the pathologic state found in families with mutations in telomere genes provides a window to study the aging process accelerated. We are currently focused on understanding how telomere dysfunction leads to lung disease. We use genetics, molecular biology, cell biology, and animal models and to investigate the mechanisms underlying telomere biology.
 Education
  • Ph.D., Cellular & Molecular Medicine, Johns Hopkins University, 2007
  • B.A., Chemistry, University of Utah, 2001
 Experience

Academic - Post-Secondary
  • Instructor, Johns Hopkins University School of Medicine, 2012-2014
  • Research Associate, Johns Hopkins University School of Medicine, 2010-2012

 Memberships
  • American Thoracic Society, 2013-Present
 Courses Taught

Fall 2016
  • PDBIO 349R: PDBio Teaching Seminar Section 001
  • PDBIO 360: Cell Biology Section 001
  • PDBIO 494R: Undergraduate Research Section 001
  • PDBIO 495R: Adv Undgraduate Research Section 001
Summer 2016
  • PDBIO 494R: Undergraduate Research Section 001
  • PDBIO 495R: Adv Undgraduate Research Section 001
Spring 2016
  • PDBIO 494R: Undergraduate Research Section 001
  • PDBIO 495R: Adv Undgraduate Research Section 001
Winter 2016
  • PDBIO 349R: PDBio Teaching Seminar Section 001
  • PDBIO 360: Cell Biology Section 001
  • PDBIO 494R: Undergraduate Research Section 001
  • PDBIO 495R: Adv Undgraduate Research Section 001

Selected Publications

Journal Articles

Alder JK, Stanley SE, Wagner CL, Hamilton M, Hanumanthu VS, Armanios M. 2014. Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis. Chest.  doi:10.1378/chest.14-1947

Stanley SE, Chen JJ, Podlevsky JD, Alder JK, Hansel NN, Mathias RA, Qi X, Rafaels NM, Wise RA, Silverman EK, et al. 2014. Telomerase mutations in smokers with severe emphysema. The Journal of Clinical Investigation.  doi:10.1172/JCI78554

Alder JK, Parry EM, Yegnasubramanian S, Wagner CL, Lieblich LM, Auerbach R, Auerbach AD, Wheelan SJ, Armanios M. 2013. Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene. Human Mutation. 34(11):1481-5.  doi:10.1002/humu.22397

Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, et al. 2011. Telomere length is a determinant of emphysema susceptibility. American Journal of Respiratory and Critical Care Medicine. 184(8):904-12.  doi:10.1164/rccm.201103-0520OC

Parry EM, Alder JK, Qi X, Chen JJ, Armanios M. 2011. Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood. 117(21):5607-11.  doi:10.1182/blood-2010-11-322149

Parry EM, Alder JK, Lee SS, Phillips, 3rd JA, Loyd JE, Duggal P, Armanios M. 2011. Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenita. Journal of medical genetics. 48(5):327-33.  doi:10.1136/jmg.2010.085100

Alder JK, Cogan JD, Brown AF, Anderson CJ, Lawson WE, Lansdorp PM, Phillips, 3rd JA, Loyd JE, Chen JJ, Armanios M. 2011. Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS genetics. 7(3):e1001352.  doi:10.1371/journal.pgen.1001352

Lebson L, Gocke A, Rosenzweig J, Alder JK, Civin C, Calabresi PA, Whartenby KA. 2010. Cutting edge: The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORγt. Journal of immunology. 185(12):7161-4.  doi:10.4049/jimmunol.1002750

Healey MA, Deaton SL, Alder JK, Winnepenninckx V, Casero, Jr RA, Herman JG. 2010. Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma. Epigenetics. 5(5):410-21.

Armanios M, Alder JK, Parry EM, Karim B, Strong MB, Greider CW. 2009. Short telomeres are sufficient to cause the degenerative defects associated with aging. American journal of human genetics. 85(6):823-32.  doi:10.1016/j.ajhg.2009.10.028

Alder JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan JD, Vulto I, Xie M, Qi X, Tuder RM, et al. 2008. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. PNAS. 105(35):13051-6.  doi:10.1073/pnas.0804280105

Alder JK, Georgantas, 3rd RW, Hildreth RL, Kaplan IM, Morisot S, Yu X, McDevitt M, Civin CI. 2008. Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. Journal of immunology. 180(8):5645-52.

Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, Lawson WE, Xie M, Vulto I, Phillips, 3rd JA, et al. 2007. Telomerase mutations in families with idiopathic pulmonary fibrosis. NEJM. 356(13):1317-26.  doi:10.1056/NEJMoa066157

Yu X, Alder JK, Chun JH, Friedman AD, Heimfeld S, Cheng L, Civin CI. 2006. HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells. 24(4):876-88.  doi:10.1634/stemcells.2005-0598

De Las Peñas A, Pan SJ, Castaño I, Alder JK, Cregg R, Cormack BP. 2003. Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing. Genes & Development. 17(18):2245-58.  doi:10.1101/gad.1121003

Flanigan KM, von Niederhausern A, Dunn DM, Alder JK, Mendell JR, Weiss RB. 2003. Rapid direct sequence analysis of the dystrophin gene. American Journal of Human Genetics. 72(4):931-9.

Dunn DM, Ishigami T, Pankow J, von Niederhausern A, Alder JK, Hunt SC, Leppert MF, Lalouel JM, Weiss RB. 2002. Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript. Journal of Human Genetics. 47(12):665-76.  doi:10.1007/s100380200102

Presentations

Hope S, Sessions J, Skousen C, Garcia B, Price K, Hanks B, Alder JK, Jensen BD. Microfabricated Lance Array Nanoinjection system delivers CRISPR-Cas9 to hundreds of thousands of cells simultaneously. International Transgenic Technologies Society 13th Conference. Prague, Czech Republic. 2016 .

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