Barrow, Jeffery

Physiology & Developmental Biology

Email: 5ojkkdgfwwt|Eg~z3jiz  (Email Form)

3049  LSB
Provo, UT 84602
(801) 422-9308

Associate Professor

Curriculum Vitae

 Research Interests
My lab focuses on elucidating mechanisms whereby genes regulate three dimensional form of organs. Our experimental model is the embryonic vertebrate limb. By modifying gene activity in subsets of cells in the limb and then observing the behavior of these modified cells over time, we are able to learn how genes ultimately regulate the overall form in the limb.

We are also studying the role of Wnt signaling in the vertebrate ectoderm. We have found that Wnt signals from the ectoderm are required to induce epidermal appendages (hair, nipples etc) as well as underlying muscle. This finding could be of clinical significance as individuals afflicted with Poland Syndrome exhibit epidermal as well as underlying muscle defects.
 Memberships
  • American Society of Cell Biology, 2003-Present
  • Society of Developmental Biology, 2003-Present
 Honors and Awards
  • College of Life Sciences : 2014 Outstanding Teaching Award
  • Brigham Young University : Ferrin L. Orton Teaching and Learning Fellowship
  • College of Life Sciences : 2012 Outstanding Teaching Award
 Courses Taught

Spring 2017
  • PDBIO 399R: Academic Internship Section 001, 002
  • PDBIO 494R: Undergraduate Research Section 003
  • PDBIO 495R: Adv Undgraduate Research Section 003
Winter 2017
  • PDBIO 399R: Academic Internship Section 001
  • PDBIO 494R: Undergraduate Research Section 003
  • PDBIO 495R: Adv Undgraduate Research Section 003
  • PDBIO 582: Developmental Genetics Section 001
Fall 2016
  • PDBIO 399R: Academic Internship Section 001
  • PDBIO 482: Developmental Biology Section 002
  • PDBIO 494R: Undergraduate Research Section 003
  • PDBIO 495R: Adv Undgraduate Research Section 003
  • PDBIO 649R: Laboratory Research Section 003
Summer 2016
  • PDBIO 399R: Academic Internship Section 002
  • PDBIO 494R: Undergraduate Research Section 003

Selected Publications

Journal Articles

Bridgewater LC, Mayo JL, Evanson BG, Whitt ME, Dean SA, Yates JD, Holden DN, Schmidt AD, Fox CL, Dhunghel S, et al. 2013. A novel bone morphogenetic protein 2 mutant mouse, nBmp2NLStm, displays impaired intracellular Ca2+ handling in skeletal muscle. BioMed Research International. 2013. <website>

Lai CJ, Kolesnikov AV, Frederick JM, Blake DR, Jiang L, Stewart JS, Chen C, Barrow JR, Baehr W, Kefalov vJ, et al. 2013. Phosducin-Like Protein 1 is Essential for G-Protein Assembly and Signaling in Retinal Rod Photoreceptors. The Journal of Neuroscience. 33(18):7941-7951.  doi:10.1523/JNEUROSCI.5001-12.2013

Barrott JJ, Cash GM, Smith AP, Barrow JR, Murtaugh LC. 2011. Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proceeding of the National Academy of Sciences. 108:12752-12757. <website>

Mayo JL, Holden DN, Barrow JR, Bridgewater LC. 2009. The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation. Experimental Cell Research. 315:2293-2300. <website>

Other

Barrow JR. 2011. Wnt/planar cell polarity signaling: An important mechanism to coordinate growth and patterning in the limb. Thomas J. Carroll, editor. Austin, TX: Landes. <website>

Presentations

Mayo JL, Nichols BA, Olsen DS, Cordner RD, Hancock CR, Weber KS, Wilson E, Edwards JG, Barrow JR, Bridgewater LC. The nBMP2 mutant mouse shows defects in intracellular calcium transport-regulated pathways. Southwest Regional Meeting of the Society for Developmental Biology. Aurora, Colorado. 2014 .

Crawford DM, Roberton CR, Mayberry R, Martinez C, Ford A, Barrow JR. Shh is required for a digit like condensation program. 72nd Annual Meeting for the Society of Developmental Biology. Cancun, Mexico. 2013 .

Crawford DM, Roberton CR, Mayberry R, Martinez C, Ford A, Barrow JR. Shh is required for a digit like condensation program. Southwest Regional Meeting of the Society of Developmental Biology. Salt Lake City, UT. 2013 .

Allen JC, Long F, McMahon AP, Barrow JR. Wnt5a signals via ß-catenin pathways to extend the embryonic axis. Southwest Regional Meeting of the Society of Developmental Biology. Salt Lake City, UT. 2013 .

Lai J, Kolesnikov AV, Jiang L, Blake DR, Stewart J, Chen C, Barrow JR, Baehr W, Kefalov VJ, Willardson BM. Conditional deletion of PhLP1 from retinal rod or cone photoreceptor cells demonstrates an essential role for PhLP1 in G protein bg and Gb5-RGS9 dimer assembly. Phosphorylation and G-protein mediated signaling networks. Biddeford, ME. 2012 .

Smith AP, Murtaugh LC, Barrow JR. Conditional Removal of Porcn in the ventral limb ectoderm results in loss of ventral limb pattern. 70th Annual Society for Developmental Biology Meeting. Chicago, Il. 2011 .

Darnell DK, Stark MR, Barrow JR, Antin P. Service Learning with GEISHA and Other Online Databases. 70th Annual Society for Developmental Biology Meeting. Chicago, Il. 2011 .

Allen J, Kendall JJ, Barrott JJ, Long F, McMahon AP, Barrow JR. Wnt5a and Wnt5b function redundantly via noncanonical pathways to extend the embryonic axis. 70th Annual Society for Developmental Biology Meeting. Chicago, Il. 2011 .

Barrow JR, Dahl TM, Smith AP, Kmetzsch KE, Low KL, Barrott JJ, Kendall JJ, Javadi M, Pitt WG. The Mesenchyme Recruitment Model for Patterning the Vertebrate Limb. 69th Annual Society of Developmental Biology Meeting. Albuquerque, NM. 2010 .

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