Tessem, Jeffery

Nutrition, Dietetics & Food Science

Email: 9snoon{‚h}n||nvIk‚~7nm~  (Email Form)

Website: http://tessemlab.byu.edu/default.aspx

S243  ESC
Provo, UT 84602
(801) 422-9082

Assistant Professor

Curriculum Vitae

 Biography
Dr. Tessem received his Bachelors degree in Microbiology from Brigham Young University in 2001 and then received his Ph.D. in Biochemistry and Molecular Biology from the University of Colorado Health Sciences Center in 2007. Dr. Tessem completed a post-doctoral fellowship with Christopher Newgard at the Duke University Medical Center's Sarah W. Stedman Center for Nutrition and Metabolism Research.
 Teaching Interests
My teaching interests focus on nutrient metabolism and biochemistry. I am interested in the metabolic disorders that cause human diseases.
 Research Interests
Both Type 1 (T1D) and Type 2 diabetes (T2D) are caused by a relative insufficiency in functional β-cell mass. Current therapeutic options for diabetes include daily insulin injections to maintain normoglycemia, pharmacological agents to stimulate β-cell function and enhance insulin sensitivity, or islet transplantation. A major obstacle to greater application of islet transplantation therapy is the scarcity of human islets. Thus, new methods for expansion of β-cell mass, applied in vitro to generate the large numbers of human islet cells needed for transplantation, or in situ to induce expansion of the patients remaining β-cells, could have broad therapeutic implications for this disease. To this end, our lab is interested in delineating the molecular pathways that increase β-cell proliferation, enhance glucose stimulated insulin secretion, and protect against β-cell death. I am also interested in the molecular changes that result in insulinoma formation and cancers that are associated with diabetes
 Education
  • , Preparing Future Faculty, Duke University, 2013
  • Ph.D., Biophysics and Genetics, University of Colorado Health Sciences Center, 2007
  • BS, Microbiology, Brigham Young University, 2001
 Experience

Academic - Post-Secondary
  • Adjunct Assistant Professor, Elon University, 2012-2013
  • JDRF and ADA-Takeda Fellow, Duke University Medical Center-Sarah W. Stedman Nutrition and Metabolism Center, 2007-2013
  • Adjunct Assistant Professor, Alamance Community College, 2011-2012
  • Adjunct Assistant Professor, North Carolina Central University, 2010-2011

 Memberships
  • American Heart Association, 2014-Present
  • American Physiological Society, 2014-Present
  • American Society for Nutrition, 2014-Present
  • Danish Diabetes Academy, 2014-Present
  • American Diabetes Association, 2011-Present
 Honors and Awards
  • American Diabetes Association : Innovative Basic Science Award
  • Diabetes Action Research and Education Foundation : Research Award
  • Utah Chapter of the Juvenile Diabetes Research Foundation : JDRF Utah Chapter Hope for the Future Award
  • Beta Cell Biology Consortium : Beta Cell Biology Consortium Investigator Scholarship
  • Keystone Symposium : Keystone Symposium/NIDDK Scholarship
 Courses Taught

Fall 2016
  • NDFS 435: Nutr Biochem & Metabolism Section 001
  • NDFS 494R: Undergrad Research in N D F S Section 008
Summer 2016
  • NDFS 435: Nutr Biochem & Metabolism Section 001
  • NDFS 494R: Undergrad Research in N D F S Section 006
Winter 2016
  • NDFS 434: Nutr Bio-organic Chemistry Section 001
  • NDFS 494R: Undergrad Research in N D F S Section 008
  • NDFS 602: Advanced Human Nutrition 2 Section 001
Fall 2015
  • NDFS 435: Nutr Biochem & Metabolism Section 001
  • NDFS 494R: Undergrad Research in N D F S Section 011

Selected Publications

Journal Articles

Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS. 2016. β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. 311(1):E186-201.  doi:10.1152/ajpendo.00022.2016

Ray JD, Kener KB, Bitner BF, Wright BJ, Ballard MB, Barrett EJ, Hill JT, Moss LG, Tessem JS. 2016. Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos. 590(12):1791-803.  doi:10.1002/1873-3468.12208

Tessem JS, Draney C, Hobson AE, Grover SG, Jack BO. 2015. Cdk5r1 Overexpression Induces Primary β-Cell Proliferation. Journal of Diabetes Research. 2016:15. <website>

Hobson A, Draney C, Stratford A, Becker TC, Lu D, Arlotto M, Tessem JS. 2015. Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway. 7(1):e1027854. <website> doi:10.1080/19382014.2015.1027854

Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. 2014. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. 111(14):5242-7.  doi:10.1073/pnas.1320953111

Tessem JS, Jensen JN, Pelli H, Dai XM, Zong XH, Stanley RE, Jensen J, DeGregori J. 2008. Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes. 57(6):1605-17. <website>

Tessem JS, Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, et al. 2008. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Molecular and Cellular Biology. 28(10):3465-76. <website>

Tessem JS, DeGregori J. 2004. Roles for bone-marrow-derived cells in beta-cell maintenance. 10(11):558-64.  doi:10.1016/j.molmed.2004.09.002

Li FX, Zhu JW, Tessem JS, Beilke J, Varella-Garcia M, Jensen J, Hogan CJ, DeGregori J. 2003. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. 100(22):12935-40.  doi:10.1073/pnas.2231861100

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