O'Neill, Kim

Microbiology & Molecular Biology

Email: 7RptfVUlpssGi€|5lk|  (Email Form)

3142  LSB
Provo, UT 84602
(801) 422-2449

Professor

 Biography
B.Sc University of Ulster
D.Phil University of Ulster from the Biomedical Sciences Research Center focus Oncology
Arrived at BYU 1992. Published 100+ pier reviewed papers over 600 presentations. mentored over 300 undergraduates in research. Four patents.
 Teaching Interests
Immunology and Molecular Biology
 Research Interests
Our Lab focuses on three main aspects of cancer research:
1. Prevention through education.
Our laboratory focuses on the benefits that can be obtained through a diet rich in fruit and vegetables. We are investigating the many dif¬ferent plant chemicals that are involved in re¬ducing cancer risk. We are studying phyto¬chemicals at the molecular level to establish the mechanisms of protection. Current studies involve gene expression by certain phytochemi¬cals, the effect of certain phytochemicals on DNA repair and immune function enhancement. We promote education by publishing our research findings in scientific jour¬nals, giving presentations at conferences and authoring chapters in scientific books.

2. Enhancing the body’s own defense systems, particularly the immune system and DNA repair mechanisms. The body has natural defenses against cancer. We study the im¬mune system and help with the development of possible vaccines that could be used against certain forms of cancer. We are currently studying the interface between the immune system and the cancer cell, focusing on tumor associated macrophages and their role in the cancer process. We have developed new methods to study angiogenesis and metastasis. Currently we are investigating the immune response to tumor cell microenvironment and see the ef¬fect on macrophages when placed in different tumor microenvironments. We have also developed the DNA repair assays that allow the measurement of certain cells repair capacity which aid in studies of apoptosis and DNA repair. Understanding how we can enhance the immune system’s ability to recognize cancer cells will play a major role in the fight against cancer. We are also studying how the disease spreads or how metastasis occurs at the molec¬ular level, including the development of essential blood vessels to allow the tumor to grow. We are currently working with macrophages to elucidate their role in cancer development. We also are developing CAR technology by genetically engineering T cells to be used as a cancer therapeutic.

3. Early detection of disease. Cancer is generally easier to treat, and a better outcome is assured, if the tumor growth is found early in its development, before metastatic spread. We have discovered a tumor marker found in serum that will aid in diagnosis, progno¬sis and tumor management. This maker accurately reflects tumor presence, and tumor stage. Several other laboratories working in this field have confirmed this research. We have developed and accurate test method for this marker, BYU has patented the dis¬covery, and it has been licensed to a biotech company for commercial development.
 Memberships
  • American Association for Cancer Research, 1992-Present
 Honors and Awards
  • BYU Alumni Association : Alumni Professorship Award
 Courses Taught

Fall 2016
  • MMBIO 121: Gen Biology: Health & Disease Section 001
  • MMBIO 162R: Careers in Biomed Sciences Section 001
  • MMBIO 399R: Academic Internship Section 001
  • MMBIO 494R: Mentored Research Section 014
  • MMBIO 514: Advanced Immunology Section 001
  • MMBIO 695R: Research Section 014
  • MMBIO 799R: Dissertation Section 014
Summer 2016
  • MMBIO 399R: Academic Internship Section 001, 002
  • MMBIO 494R: Mentored Research Section 013
  • MMBIO 695R: Research Section 013
Spring 2016
  • MMBIO 399R: Academic Internship Section 001, 002
  • MMBIO 494R: Mentored Research Section 013
  • MMBIO 695R: Research Section 013
  • MMBIO 799R: Dissertation Section 013
Winter 2016
  • MMBIO 121: Gen Biology: Health & Disease Section 001
  • MMBIO 494R: Mentored Research Section 014
  • MMBIO 695R: Research Section 013

Selected Publications

Journal Articles

Shrestha G, StClair LL, O'Neill KL. 2014. The immunostimulating role of lichen polysaccahrides: A Review. Phytotherapy Research.  doi:10.1002/ptr.5251

Shrestha G, El-Naggar AM, StClair LL, O'Neill KL. 2014. Anticancer Activities of Selected Species of North American Lichen Extracts. Phytotherapy Research.  doi:10.1002/ptr.5233

Clifford AB, Elnaggar AM, Robison RA, O'Neill KL. 2013. Investigating the role of macrophages in tumor formation using a MaFIA mouse model. Oncology Reports. 30(2):890-896.  doi:10.3892/or.2013.2508

Lowe C, March JK, Bunnell AJ, O'Neill KL, Robison RA. 2013. PCR-based methodologies used to detect and differentiate the Burkholderia pseudomallei complex: B. pseudomallei, B. mallei, and B. thailandensis. Current Issues in Molecular Biology. 16:23-54.

Robison RA, Robison RA, O'Neill KL. 2013. Thymidine kinase 1: a universal marker for cancer. Cancer and Clinical Oncology. 2(1):159-167.

Robison RA, March JK, Cohen MN, Lindsey JM, Millar DA, Lowe C, Bunnell AJ, Schaalje GB, O'Neill KL. 2012. The differential susceptibility of spores from virulent and attenuated Bacillus anthracis strains to aldehyde- and hypochlorite-based disinfectants. MicrobiologyOpen. 1-8. <website>

Robison RA, Gunnell MK, Lovelace CD, Satterfield BA, Moore EA, O'Neill KL. 2012. A multiplex real-time PCR assay for the detection and differentiation of Francisella tularensis subspecies. Journal of Medical Microbiology. 61:1525-1531.

Gupta-Elera G, Garrett A, Martinez A, Kraus R, Robison RA, O'Neill KL. 2012. A Comparison of Antioxidant Properties in Organic and Conventional Blueberries. Journal of Food Research. 1(3):1-7.

Alegre M, Robison RA, O'Neill KL. 2012. Thymidine kinase 1 upregulation is an early event in breast tumor formation. Journal of Oncology. 2012:5.

Alegre MM, Robison RA, O'Neill KL. 2012. Thymidine kinase 1upregulation is an early event in breast tumor formation. Journal of Oncology. 1-5.  doi:10.1155/2012/575647

Gupta G, Garrett A, Robison RA, O'Neill KL. 2012. The role of oxidative stress in prostate cancer -a review. European Journal of Cancer Prevention. 21(2):155-162.

Satterfield BA, Stewart AF, Lew CS, Pickett DO, Cohen M, Moore EA, Luedtke PF, O'Neill KL, Robison RA. 2010. A quadraplexed real-time PCR assay for rapid detection and differentiation of the Clostridium botulinum toxin genes A, B, E and F. Journal of Medical Microbiology. 59(1):55-64.

Pitt WG, Husseini GA, El-Fayoumi RI, O'Neill KL, Rapoport NY. 2000. DNA Damage Induced by Micellar-Delivered Doxorubicin and Ultrasound: Comet Assay Study. Cancer Letters. 154(211-216).

Presentations

StClair LL, Gajendra S, D. LS, O'Neill KL. Can we cure cancer with lichens?. American Bryological and Lichenological Society. New Orleans, Louisiana. 2013 .

Memmott T, Weagel E, Livingstone J, Liu P, Elnaggar A, Robison RA, O'Neill KL. Investigating macrophage induction of metastasis: a precursor to identify therapeutic targets. American Society of Gene and Cell Therapy. Salt Lake City. 2013 .

Shrestha, G, Elnaggar A, Boswell M, Derenthal S, Weagel E, StClair LL, Robison RA, O'Neill KL. Cytototoxicity and mode of action of two lichen extracts, Tuckermannopsis ciliaris and Xanthoparmelia chlorochroa against Burkitt’s Lymphoma (Raji) cell and Human colon cancer cell line (HT-29)’. 8th Annual Undergraduate Student Caucus and Poster Competition. Washington DC. 2013 .

Steck R, Wells M, Elnaggar A, O'Neill KL. Phagocytic regulation through exogenous caffeine exposure in whole-blood macrophages. 8th Annual Undergraduate Student Caucus and Poster Competition. Washington DC. 2013 .

Helsing AV, Lynch P, Xiao M, Ramsden M, Alegre F, Weagel E, Elnaggar A, McCoy J, Robison RA, O'Neill KL. The Potential of Resveratrol and Nagami Kumquat extracts in facilitating DNA repair in Raji cells’. 8th Annual Undergraduate Student Caucus and Poster Competition. Washington DC. 2013 .

Shrestha, G, Elnaggar A, Boswell M, Dereenthal S, Weagel E, StClair LL, Robison RA, O'Neill KL. Cytototoxicity and mode of action of two lichen extracts, Tuckermannopsis ciliaris and Xanthoparmelia chlorochroa against Burkitt’s Lymphoma (Raji) cell and Human colon cancer cell line (HT-29)’. Annual Meeting. Washington DC. 2013 .

Weagel E, Martinez A, Elnaggar A, Ellis S, Liu P, Robison RA, O'Neill KL. Differences in cellular antioxidant activity in Burkitt’s lymphoma and normal human lymphocytes’. Annual Meeting. Washington DC. 2013 .

Xiao M, Elnaggar A, Helsing A, Lynch P, Alegre M, Robison RA, O'Neill KL. Mutagenic effects of inorganic particulate matter on Raji and HepG2 cell lines exposed to ultraviolet radiation’. Annual Meeting. Washington DC. 2013 .

Steck R, Wells M, Liu P, ELnaggar A, O'Neill KL. Phagocytic regulation through exogenous caffeine exposure in whole-blood macrophages. Annual Meeting. Washington DC. 2013 .

Hesling A, Elnaggar A, Lynch P, Xiao M, Ramsden M, Alegre F, Weagel E, McCoy J, Robison RA, O'Neill KL. The Potential of Resveratrol and Nagami Kumquat extracts in facilitating DNA repair in Raji cells’. Annual Meeting. Washington DC. 2013 .

O'Neill KL, Livingstone J, Lee E, Barlow S, ELnaggar A, Weagel E, Liu P, Robison RA. Macrophages may be polarized by apoptotic and necrotic cancer cells. intermountain Branch meeting of the American Society for Microbiology. Idaho State University, Pocatello, Idaho,. 2013 .

O'Neill KL, Elnaggar A, Clement A, Robison RA. A Tumor Microenvironment Rich in Macrophages could be Aiding Metastasis’. Molecular and Cellular Biology. Dublin, Ireland. 2012 .

O'Neill KL, Kraus R, Martinez A, Measom K, Gill M, Gupta-Elera G, Garrett A, Robison RA. Blueberries: Conventional Cancer Prevention. Annual Meeting of the American Association for Cancer Research. Chicago. 2012 .

O'Neill KL, Elnaggar A, Chavez A, Peterson E, Kuttab R, Robison RA. S2AMN: A potential non- toxic anti-cancer therapy. Annual Meeting of the American Association for Cancer Research. Chicago. 2012 .

O'Neill KL, Alegre M, Germann B, Leavitt M, Eggett D, Killpack N, Burton S, Orton A, Leavitt C. Setting the Clock: Tumor TK1 is a Prognostic Marker for Disease Recurrence. Annual Meeting of the American Association for Cancer Research. Chicago. 2012 .

O'Neill KL, Measom K, Martinez A, Sharp E, Michaelis T. ‘How ‘Bout them Apples?. Annual Meeting of the American Association for Cancer Research. Chicago. 2012 .

O'Neill KL, McCoy J, Grooms A, Emerson J, Kraus R, Martinez A, Elnaggar A. ‘Fortunella margarita: The little gold gem of the citrus family. Undergraduate Caucus of the American Association for Cancer Research. Chicago. 2012 .

O'Neill KL, Measom K, Martinez A, Sharp E, Michaelis TC. ‘How ‘Bout them Apples?. Undergraduate Caucus of the American Association for Cancer Research. Chicago. 2012 .

Jensen NR, O'Neill KL, Robison RA. CRISPR loci and bacteriophage: a mutually exclusive relationship in pathogenic bacteria. Annual Meeting of the Intermountain Branch of the American Society for Microbiology. Ogden, UT. 2011 .

Meyers JM, Ryndock E, Conway MJ, Meyers CM, O'Neill KL, Robison RA. The susceptibility of HPV16 native and quasivirus particles to clinically relevant disinfectants. 26th International Papillomavirus Conference. Montreal, Qc, Canada. 2010 .

Bills TM, Shepherd QC, Blam AJ, Moore EA, Gardner JS, Schaalje GB, O'Neill KL, Robison RA. Improved recovery of spores from coated carriers used in the AOAC Sporicidal Activity of Disinfectants (Method II) spore enumeration method, by addition of a surfactant to the rinse solution. General Meeting of the American Society for Microbiology. San Diego, CA. 2010 .

Meyers JM, Ryndock E, Conway MJ, O'Neill KL, Meyers CM, Robison RA. Susceptibility of native and synthetic HPV16 virions to clinical disinfection. General Meeting of the American Society for Microbiology. San Diego, CA. 2010 .

Bills TM, Shepherd QC, Blam AJ, Moore EA, Gardner JS, Schaalje GB, O'Neill KL, Robison RA. Improved recovery of spores from coated carriers used in the AOAC Sporicidal Activity of Disinfectants (Method II) spore enumeration method, by addition of a surfactant to the rinse solution. Intermountain Branch of the American Society for Microbiology Annual Meeting. Provo, UT. 2010 .

Gunnell MK, Carter CD, Jonas WS, Satterfield BA, Moore EA, O'Neill KL, Robison RA. A multiplex real-time PCR assay for the detection and differentiation of Francisella tularensis subspecies. 3rd Annual Biothreat Agent Workshop. Charlotte, NC. 2010 .

Gunnell MK, Carter CD, Jonas WS, Satterfield BA, Moore EA, O'Neill KL, Robison RA. A multiplex real-time PCR assay for the detection and differentiation of Francisella tularensis subspecies. 8th Annual ASM Biodefense and Emerging Disease Research Meeting. Baltimore, MD. 2010 .

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