Weber, Scott

Microbiology & Molecular Biology

Email: 8{kw||gmjmzHj}6ml}  (Email Form)

Website: http://weberlab.byu.edu/

3137  LSB
Provo, UT 84602
(801) 422-6259

Assistant Professor

Curriculum Vitae

 Biography
I am an Assistant Professor in the Department of Microbiology and Molecular Biology at Brigham Young University. My research is centered on improving the immune system response to infectious disease and I teach Advanced Molecular Biology.

Previously I was an Instructor and Postdoctoral Fellow at the Washington University School of Medicine in St. Louis. I earned my Ph.D. from the University of Illinois and my undergraduate and masters degrees are from Brigham Young University.
 Teaching Interests
Immunology, Host-pathogen interactions, and Molecular Biology
 Research Interests
My research group is working to understand the mechanisms of T cell activation and memory cell formation in response to pathogens. Memory cell formation is a hallmark of the adaptive immune system and memory T cells rapidly respond to a secondary challenge and are critical for numerous vaccine strategies. In recent years our understanding of cytotoxic memory T cells has increased substantially, but our understanding of memory helper T cells remains incomplete. We have generated two helper T cell receptor transgenic mice specific for the same naturally occurring epitope from Listeria monocytogenes. T cells from these mice have dramatically different primary and secondary responses to infection. This project will help us better understand ways to effectively improve vaccines and immunity to infection.

A second focus of my lab is to understand how high affinity T cell receptors differ in their ability to recognize antigen and cause T cell activation. High affinity T cell receptors are engineered using yeast display and directed evolution and represent a novel tool for targeting T cell epitopes that are not recognized by antibodies. High affinity T cells may be useful as therapeutics in an infectious disease setting when coupled with pro-inflammatory cytokines or in an autoimmune setting when coupled with anti-inflammatory cytokines.
 Education
  • Ph.D., Cell and Structural Biology, University of Illinois, 2005
  • M.S., Zoology, Brigham Young University, 2000
  • B.S., Zoology, Brigham Young University, 1998
 Experience

Professional
  • Assistant Professor, Brigham Young University, 2012-Present
  • Research Instructor, Washington University Medical School, 2009-2012
  • Postdoctoral Fellow, Washington University Medical School, 2005-2009

 Memberships
  • American Association of Cancer Research, 2015-Present
 Courses Taught

Fall 2016
  • MMBIO 494R: Mentored Research Section 018
  • MMBIO 522: Flow Cytometry Section 001
  • MMBIO 695R: Research Section 018
Summer 2016
  • MMBIO 494R: Mentored Research Section 017
  • MMBIO 695R: Research Section 017
Spring 2016
  • MMBIO 494R: Mentored Research Section 017
  • MMBIO 695R: Research Section 017
Winter 2016
  • MMBIO 442: Adv Molecular Biology Lab Section 002
  • MMBIO 463: Immunology Section 001
  • MMBIO 494R: Mentored Research Section 018
  • MMBIO 551R: Current Topics Section 004
  • MMBIO 695R: Research Section 017

Selected Publications

Journal Articles

Johnston JD, Kruman B, Nelson M, Merrill RM, Graul R, Hoybjerg T, Tuttle S, Myers S, Cook R, Weber KS. 2017. Differential effects of air conditioning type on residential endotoxin levels in a semi-arid climate. Indoor Air. 1-9. <website> doi:10.1111/ina.12369

Johnston JD, Barney T, Crandall J, Brown M, Westover T, Paulson S, Smith M, Weber KS. 2017. Dust mite allergens in low-income homes with evaporative coolers in a semi-arid climate. Archives of Environmental and Occupational Health.  doi:http://dx.doi.org/10.1080/19338244.2017.1282846

Johnston JD, Tuttle SC, Nelson MC, Bradshaw RK, Hoybjerg TG, Johnson JB, Kruman BA, Orton TS, Cook RB, Eggett DL, et al. 2016. Evaporative Cooler Use Influences Temporal Indoor Relative Humidity but not Dust Mite Allergen Levels in Homes in a Semi-arid Climate. PLOS ONE. 11(1).  doi:10.1371/journal.pone.0147105

Steck R, Hill S, Weigel E, Weber KS, Robison RA, O'Neill KL. 2015. Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine. Pharmacology Research & Perspectives. 3(6). <website> doi:10.1002/prp2.180

Persuad SP, Parker CR, Weber KS, Allen PM. 2014. Intrinsic CD4+ T cell sensitivity and response to pathogen are set and sustained by avidity for thymic and peripheral self-pMHC. Nature Immunology. <website>

Lynch JN, Donermeyer DL, Weber KS, Kranz DM, Allen PM. 2013. Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells. Molecular Immunology. 53(3):283-294. <website>

Graw F, Weber KS, Allen PM, Perelson AS. 2012. Dynamics of CD4+ T Cell Responses against Listeria monocytogenes. Journal of Immunology. 189(11):5250-5256. <website>

Weber KS, Li QJ, Persaud SP, Campbell JD, Davis MD, Allen PM. 2012. Distinct populations of CD4+ helper T cells mediate CD4+ and CD8+ memory responses to infection. Proceedings of the National Academy of Sciences. U S A. 109(24):9511-9516. <website>

Weber KS, Hildner K, Murphy KM, Allen PM. 2010. Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. Journal of Immunology. 185(5):2836-2846. <website>

Persaud SP, Donermeyer DL, Weber KS, Kranz DM, Allen PM. 2010. High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics. Molecular Immunology. 47(9):1793-801. <website>

Morley SC, Weber KS, Kao H, Allen PM. 2008. Protein kinase C-θ is required for efficient positive selection. Journal of Immunology. 180(3):1442-1450. <website>

Weber KS, Miller MJ, Allen PM. 2008. Th17 cells exhibit a distinct calcium profile from Th1 and Th2 cells and have Th1-like motility and NFAT nuclear localization. Journal of Immunology. 180(3):1442-1450. <website>

Donermeyer DL, Weber KS, Kranz DM, Allen PM. 2006. The study of high affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy. Journal of Immunology. 177(10):6911-6919. <website>

Richman SA, Healan SJ, Weber KS, Donermeyer DL, Dossett ML, Greenberg PD, Allen PM, Kranz DM. 2006. Development of a novel strategy for engineering high-affinity proteins by yeast display. Protein Engineering, Design, and Selection. 19(6):255-264. <website>

Weber KS, Donermeyer DL, Allen PM, Kranz DM. 2005. Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proceedings of the National Academy of Sciences. U S A. 102(52):19033-19038. <website>

Lephart ED, West TW, Weber KS, Rhees RW, Setchell KD, Adlercreutz H, Lund TD. 2002. Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicology and Teratology. 24, 5-16. <website>

Roper RJ, Weis JJ, McCracken BA, Green CB, Ma Y, Weber KS, Fairbairn D, Butterfield RJ, Potter MR, Zachary JF, et al. 2001. Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes and Immunity. 2, 388-397. <website>

Weber KS, Setchell KD, Stocco DM, Lephart ED. 2001. Dietary soy-phytoestrogens decrease testosterone levels and prostate weight, without altering LH, prostate 5α-reductase or testicular StAR levels in adult male Sprague-Dawley rats. Journal of Endocrinology. 170, 591-599. <website>

Weber KS, Setchell KD, Lephart ED. 2001. Maternal and perinatal brain aromatase: Effects of dietary soy phytoestrogens. Developmental Brain Research. 126, 217-221. <website>

Lephart ED, Call SB, Rhees RW, Jacobson NA, Weber KS, Bledsoe J, Teuscher C. 2001. Neuroendocrine regulation of sexually dimorphic brain structure and associated sexual behavior in male rats is genetically controlled. Biology of Reproduction. 64, 571-578. <website>

Lephart ED, Thompson JM, Setchell KD, Adlercreutz H, Weber KS. 2000. Phytoestrogens decrease brain calcium binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Brain Research. 859, 123-131. <website>

Weber KS, Jacobson NA, Setchell KD, Lephart ED. 1999. Brain aromatase and 5 alpha reductase, regulatory behaviors and testosterone levels in adult rats on phytoestrogen diets. Proceedings of the Society for Experimental Biology and Medicine. 221(2), 131-135. <website>

Book Chapter

Stone JD, Yin Y, Mo M, Weber KS, Donermeyer DL, Allen PM, Mariuzza RA, Kranz DM. 2012. Engineering High-Affinity T Cell Receptor/ Cytokine Fusions for Therapeutic Targeting, Protein Engineering. , editor. InTech. p. ISBN: 978-953-51-0037-9 <website>

Presentations

Graul RJ, Tuttle SC, Kruman BA, Nelson MC, Hoybjerg TG, Meyers S, Cook RB, Eggett DL, Weber KS, Johnston JD. Differences in indoor dust endotoxin levels based on type of air conditionig in homes in a semi-arid climate. NEHA 2016 AEC and HUD Healthy Homes Conference. San Antonio, TX. 2016 .

Brown M, Barney T, Westover T, Paulson S, Smith M, Crandall J, Weber KS, Johnston JD. Dust mite allergens in low-income homes with evaporative coolers in a semi-arid climate. NEHA 2016 AEC and HUD Healthy Homes Conference. San Antonio, TX. 2016 .

Mayo JL, Nichols BA, Olsen DS, Cordner RD, Hancock CR, Weber KS, Wilson E, Edwards JG, Barrow JR, Bridgewater LC. The nBMP2 mutant mouse shows defects in intracellular calcium transport-regulated pathways. Southwest Regional Meeting of the Society for Developmental Biology. Aurora, Colorado. 2014 .

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