Hansen, Marc

Physiology & Developmental Biology

Email: 8uizkpiv{mvHj}6ml}  (Email Form)

3067  LSB
Provo, UT 84602
(801) 422-4998

Associate Professor

 Biography
I am from Vancouver Island (Victoria) in BC, Canada, attended BYU from 1991 to 1997 with a mission in Marseille, France during that time. After a BS in Molecular Biology from BYU, I earned a PhD in Cancer Research from Stanford and completed a post-doc at Huntsman Cancer Institute. I enjoy wilderness exploration on foot and by mountain bike, as well as eating strange and exotic food.
 Teaching Interests
I teach introductory biology for majors (PDBIO120) and have taught Cell Biology (PDBIO360) and Histology (PDBIO325) in the past. Outside of molecular and cell biology, I am interested in teaching BIO-innovation courses. These courses address how technologies and ideas rooted in the life sciences become new companies that create prosperity and jobs?
 Research Interests
I came to BYU seeking to understand the signaling, regulation, and cellular mechanics of how individual epithelial cells detach from epithelial tissues, a process called epithelial-mesenchymal transition that occurs throughout development and that is recapitulaled in cancer metastasis. After over 10 years of dissecting this process, serendipity has led us to the identification of a novel small molecule drug that may soon enter clinical trials and my current research efforts are centered around defining the mechanism and potential clinical utility of this compound to build a case for its eventual clinical testing and approval. We now study mechanisms and cross resistance of tubulin targeting drugs, their combination with other anticancer agents, and how their toxicity can be reduced.
 Experience

Professional
  • Visiting Researcher, Imperial College London, 2012-2013

 Memberships
  • American Association of Cancer Researchers, 2012-Present
  • American Society of Cell Biologists, 1998-Present
 Courses Taught

Summer 2016
  • PDBIO 494R: Undergraduate Research Section 008
  • PDBIO 495R: Adv Undgraduate Research Section 008
  • PDBIO 799R: Dissertation Section 004
Spring 2016
  • PDBIO 494R: Undergraduate Research Section 008
  • PDBIO 495R: Adv Undgraduate Research Section 008
  • PDBIO 799R: Dissertation Section 005
Winter 2016
  • PDBIO 349R: PDBio Teaching Seminar Section 010
  • PDBIO 455R: PDBio Seminar Section 001
  • PDBIO 494R: Undergraduate Research Section 008
  • PDBIO 495R: Adv Undgraduate Research Section 008
  • PDBIO 550R: Advanced Topics Section 010, 011
  • PDBIO 699R: Master's Thesis Section 008
  • PDBIO 799R: Dissertation Section 008
Fall 2015
  • PDBIO 120: Science of Biology Section 005, 006
  • PDBIO 349R: PDBio Teaching Seminar Section 008
  • PDBIO 455R: PDBio Seminar Section 001
  • PDBIO 494R: Undergraduate Research Section 010
  • PDBIO 495R: Adv Undgraduate Research Section 009
  • PDBIO 498: Advanced Senior Research Section 001
  • PDBIO 550R: Advanced Topics Section 010
  • PDBIO 649R: Laboratory Research Section 009
  • PDBIO 699R: Master's Thesis Section 009
  • PDBIO 799R: Dissertation Section 007

Selected Publications

Journal Articles

Hansen MD, Hoj J, Davis J, Fullmer K, Morrell D, Saguibo N. Cellular Contractility Changes are Sufficient to Drive Cellular Scattering. Experimental Cell Research. 2014 Apr;In press.

Barcellos K, Wagner M, Langford P, Call SG, Staley D, Chung J, Hansen MD. ARHGAP21: a new partner of α-tubulin involved in cell-cell adhesion formation and essential for Epithelial-Mesenchymal Transition. Journal of Biological Chemistry. 2013 Jan:epub.

Jake G, Moody J, Ascione M, Hansen MD. Zyxin-VASP interactions alter actin regulatory activity in zyxin-VASP complexes. Cellular and Molecular Biology Letters. 2013 Jan:epub.

Hansen MD. Control of actin dynamics by allosteric regulation of actin binding proteins. International Review in Cellular and Molecular Biology. 2013 Jan.

Langford P, Keyes L, Hansen MD. Plasma membrane ion fluxes and NFAT-dependent gene transcription contribute to c-met-induced epithelial scattering. Journal of Cell Science. 2012;125:4001-4013.

Call SG, Brereton D, Bullard JT, Chung JY, Meacham KL, Morrell DJ, Reeder DJ, Schuler JT, Slade AD, Hansen MD. A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions. Biochemistry and Biophysics Research Communications. 2011 Nov;415:485-489.

Langford PR, Hansen MD. Initiation of epithelial-mesenchymal transition by c-met receptor tyrosine kinase signaling. Current Topics in Biochemical Research. 2011 Oct;13:81-90.

Chung JY, Davis JA, Price B, Staley DM, Wagner MV, Warner SL, Bearss DJ, Hansen MD. Competitive enhancement of HGF-induced epithelial scattering by accessory growth factors. Experimnetal Cell Research. 2011 Feb;317:307-318.

Call SG, Chung JY, Davis JA, Proce BD, Primavera TS, Thomson NC, Wagner MV, Hansen MD. Zyxin phosphorylation at serine 142 modulates the zyxin head-tail interaction to alter cell-cell adhesion. Biochemistry and Biophysics Research Communications. 2011 Jan;404:780-784.

Sperry R, Bishop N, Bramwell J, Carter M, Fowler B, Maxfield S, Lewis Z, Staley D, Vellinga R, Brodeur M, et al. Actin-membrane linkages at adherens junctions of cell undergoing epithelial-mesenchyme transition. Journal of Cellular Physiology. 2010 Mar;222:612-624.