Robison, Richard

Microbiology & Molecular Biology

Email: 9[rlqj{mh[xkr|xwIk‚~7nm~  (Email Form)

4007B  LSB
Provo, UT 84602
(801) 422-2416

Professor

Curriculum Vitae

 Teaching Interests
General microbiology, immunology, and bacterial pathogenesis
 Research Interests
Bacterial agents that cause disease in man and animals are the focus of our research. Pathogenic mechanisms these organisms use to evade host immune mechanisms and cause disease is a specific focus.

We are interested in all CDC select agents as well as pathogens within the genera Pasteurella and Myobacterium. The genetic diversity of these pathogens, their virulence factors, and the development of multiplexed real-time PCR detection assays, are some areas in which we are currently working.

Particular species in which we are interested include: Pasteurella multocida (the agent of fowl cholera), Burkholderia pseudomallei (the etiologic agent of melioidosis), Burkholderia mallei (the etiologic agent of glanders), and pathogenic members of the genus Mycobacterium including M. ulcerans (the etiologic agent of Buruli ulcer) and drug-resistant isolates of M. tuberculosis.

In addition to the above, we also maintain an active interest in the areas of decontamination, disinfection, and infection control. We are currently performing research on compounds and devices that are capable of high-level disinfection (with an emphasis on tuberculocidal activity) and/or sterilization.
 Administrative Positions
Department Chair
 Memberships
  • Amercian Association for Cancer Research, 1998-Present
  • American Society for Microbiology, 1991-Present
 Courses Taught

Fall 2016
  • MMBIO 221: General Microbiology Section 003
  • MMBIO 494R: Mentored Research Section 016, 021
  • MMBIO 528R: Current Topics in Pathogenesis Section 001
  • MMBIO 551R: Current Topics in MMBio Section 001
  • MMBIO 695R: Research Section 016
  • MMBIO 699R: Master's Thesis Section 016
Summer 2016
  • MMBIO 494R: Mentored Research Section 015
  • MMBIO 695R: Research Section 015
  • MMBIO 699R: Master's Thesis Section 016
Spring 2016
  • MMBIO 494R: Mentored Research Section 015
  • MMBIO 695R: Research Section 015
Winter 2016
  • MMBIO 221: General Microbiology Section 003
  • MMBIO 494R: Mentored Research Section 016
  • MMBIO 528R: Current Topics in Pathogenesis Section 001
  • MMBIO 695R: Research Section 015
  • MMBIO 699R: Master's Thesis Section 016

Selected Publications

Journal Articles

Pitt WG, Alizadeh M, Husseini GA, McClellan D, Buchannan C, Bledsoe C, Robison RA, Blanco R, Roeder BL, Melville M, et al. 2016. Rapid Separation of Bacteria from Blood – Review and Outlook. Biotechnology Progress. 32(4):823-839. <website> doi:10.1002/btpr.2299

Gunnell MK, Robison RA, Adams BJ. 2016. Natural Selection in Virulence Genes of Francisella tularensis. 82(6):264-278. <website> doi:10.1007/s00239-016-9743-y

Gunnell MK, Adams BJ, Robison RA. 2016. The Genetic Diversity and Evolution of Francisella tularensis with Comments on Detection by PCR. Current Issues in Molecular Biology. 18:79-91. <website>

Meyers J, Ryndock E, Conway MJ, Meyers C, Robison RA. 2014. Susceptibility of high-risk human papillomavirus type 16 to clinical disinfectants. Journal of Antimicrobial Chemotherapy. 1-5.  doi:10.1093/jac/dku006

Clifford AB, Elnaggar AM, Robison RA, O'Neill KL. 2013. Investigating the role of macrophages in tumor formation using a MaFIA mouse model. Oncology Reports. 30(2):890-896.  doi:10.3892/or.2013.2508

Lowe C, March JK, Bunnell AJ, O'Neill KL, Robison RA. 2013. PCR-based methodologies used to detect and differentiate the Burkholderia pseudomallei complex: B. pseudomallei, B. mallei, and B. thailandensis. Current Issues in Molecular Biology. 16:23-54.

Li D, March JK, Bills TM, Holt BC, Wilson CE, Lowe C, Tolley HD, Lee ML, Robison RA. 2013. Gas chromatography-mass spectrometry method for rapid identification and differentiation of Burkholderia pseudomallei, B. mallei, and B. thailandensis from several members of the B. cepacia complex. Journal of Applied Microbiology. 115:1159-1171.  doi:10.1111/jam.12310

Robison RA, Robison RA, O'Neill KL. 2013. Thymidine kinase 1: a universal marker for cancer. Cancer and Clinical Oncology. 2(1):159-167.

Robison RA, March JK, Cohen MN, Lindsey JM, Millar DA, Lowe C, Bunnell AJ, Schaalje GB, O'Neill KL. 2012. The differential susceptibility of spores from virulent and attenuated Bacillus anthracis strains to aldehyde- and hypochlorite-based disinfectants. MicrobiologyOpen. 1-8. <website>

Robison RA, Gunnell MK, Lovelace CD, Satterfield BA, Moore EA, O'Neill KL. 2012. A multiplex real-time PCR assay for the detection and differentiation of Francisella tularensis subspecies. Journal of Medical Microbiology. 61:1525-1531.

Gupta-Elera G, Garrett A, Martinez A, Kraus R, Robison RA, O'Neill KL. 2012. A Comparison of Antioxidant Properties in Organic and Conventional Blueberries. Journal of Food Research. 1(3):1-7.

Alegre M, Robison RA, O'Neill KL. 2012. Thymidine kinase 1 upregulation is an early event in breast tumor formation. Journal of Oncology. 2012:5.

Alegre MM, Robison RA, O'Neill KL. 2012. Thymidine kinase 1upregulation is an early event in breast tumor formation. Journal of Oncology. 1-5.  doi:10.1155/2012/575647

Gupta G, Garrett A, Robison RA, O'Neill KL. 2012. The role of oxidative stress in prostate cancer -a review. European Journal of Cancer Prevention. 21(2):155-162.

Dudleenamjil E, Lin CY, Dredge D, Murray B, Robison RA, Johnson FB. 2010. Bovine parvovirus uses clathrin-mediated endocytosis for cell entry. Journal of General Virology. 91:3032-3041.

Margolis JM, El-Etr S, Joubert LM, Moore EA, Robison RA, Rasley A, Spormann AM, Monack DM. 2010. Contributions of Francisella tularensis subsp. novicida chitinases and Sec secretion system to biofilm formation on chitin. Applied and Environmental Microbiology. 76(2):596-608.

Mitchell AM, Strobel GA, Moore E, Robison RA, Sears J. 2010. Volatile antimicrobials from Muscodor crispans, a novel endophytic fungus. Microbiology. 156(1):270-277.

Satterfield BA, Stewart AF, Lew CS, Pickett DO, Cohen M, Moore EA, Luedtke PF, O'Neill KL, Robison RA. 2010. A quadraplexed real-time PCR assay for rapid detection and differentiation of the Clostridium botulinum toxin genes A, B, E and F. Journal of Medical Microbiology. 59(1):55-64.

Presentations

Ryndock E, Robison RA, Burdach J, Weinberger R, Meyers C. The efficacy of an automated ultrasound probe disinfector against high-risk human papillomavirus type 16 and 18. 30th International Papillomavirus Conference. Lisbon, Portugal. 2015 .

Shrestha G, Thompson GA, Leavitt SD, Robison RA, StClair LL. Lichens, Man's New Best Friend: How the Lichen Mycobiont Might Defeat Bacterial Pathogens. Botanical Society of America. Boise Idaho. 2014 .

Bennallack P, Burt SR, Robison RA, Griffitts JS. Offense and Defense: Antimicrobial thiopeptide production and resistance in Staphylococcus epidermidis. Gordon Conference: Microbial Stress Response. Mount Holyoke College. 2014 .

Bennallack P, Robison RA, Griffitts JS. Genetic Insights Into the Mechanism of Host Immunity in Staphylococcus epidermidis Strain 115: a Novel Micrococcin P1 Producing Strain. ASM Branch Meeting. BYU. 2014 .

Bennallack P, Robison RA, Griffitts JS. Genetic insights into the mechanism of host immunity in Staphylococcus epidermidis strain 115: a novel micrococcin P1 producing strain. Intermountain Branch of the American Society for Microbiology Annual Meeting. Provo, UT. 2014 .

Memmott T, Weagel E, Livingstone J, Liu P, Elnaggar A, Robison RA, O'Neill KL. Investigating macrophage induction of metastasis: a precursor to identify therapeutic targets. American Society of Gene and Cell Therapy. Salt Lake City. 2013 .

March JK, Li D, Holt BC, Wilson CE, Lowe C, Tolley HD, Lee ML, Robison RA. GC/MS method for rapid identification and differentiation of Burkholderia pseudomallei, Burkholderia mallei, Burkholderia thailandensis, and several members of the Burkholderia cepacia complex. General Meeting of the American Society for Microbiology. Denver, CO. 2013 .

Shrestha, G, Elnaggar A, Boswell M, Derenthal S, Weagel E, StClair LL, Robison RA, O'Neill KL. Cytototoxicity and mode of action of two lichen extracts, Tuckermannopsis ciliaris and Xanthoparmelia chlorochroa against Burkitt’s Lymphoma (Raji) cell and Human colon cancer cell line (HT-29)’. 8th Annual Undergraduate Student Caucus and Poster Competition. Washington DC. 2013 .

Helsing AV, Lynch P, Xiao M, Ramsden M, Alegre F, Weagel E, Elnaggar A, McCoy J, Robison RA, O'Neill KL. The Potential of Resveratrol and Nagami Kumquat extracts in facilitating DNA repair in Raji cells’. 8th Annual Undergraduate Student Caucus and Poster Competition. Washington DC. 2013 .

Shrestha, G, Elnaggar A, Boswell M, Dereenthal S, Weagel E, StClair LL, Robison RA, O'Neill KL. Cytototoxicity and mode of action of two lichen extracts, Tuckermannopsis ciliaris and Xanthoparmelia chlorochroa against Burkitt’s Lymphoma (Raji) cell and Human colon cancer cell line (HT-29)’. Annual Meeting. Washington DC. 2013 .

Weagel E, Martinez A, Elnaggar A, Ellis S, Liu P, Robison RA, O'Neill KL. Differences in cellular antioxidant activity in Burkitt’s lymphoma and normal human lymphocytes’. Annual Meeting. Washington DC. 2013 .

Xiao M, Elnaggar A, Helsing A, Lynch P, Alegre M, Robison RA, O'Neill KL. Mutagenic effects of inorganic particulate matter on Raji and HepG2 cell lines exposed to ultraviolet radiation’. Annual Meeting. Washington DC. 2013 .

Hesling A, Elnaggar A, Lynch P, Xiao M, Ramsden M, Alegre F, Weagel E, McCoy J, Robison RA, O'Neill KL. The Potential of Resveratrol and Nagami Kumquat extracts in facilitating DNA repair in Raji cells’. Annual Meeting. Washington DC. 2013 .

O'Neill KL, Livingstone J, Lee E, Barlow S, ELnaggar A, Weagel E, Liu P, Robison RA. Macrophages may be polarized by apoptotic and necrotic cancer cells. intermountain Branch meeting of the American Society for Microbiology. Idaho State University, Pocatello, Idaho,. 2013 .

O'Neill KL, Elnaggar A, Clement A, Robison RA. A Tumor Microenvironment Rich in Macrophages could be Aiding Metastasis’. Molecular and Cellular Biology. Dublin, Ireland. 2012 .

O'Neill KL, Kraus R, Martinez A, Measom K, Gill M, Gupta-Elera G, Garrett A, Robison RA. Blueberries: Conventional Cancer Prevention. Annual Meeting of the American Association for Cancer Research. Chicago. 2012 .

O'Neill KL, Elnaggar A, Chavez A, Peterson E, Kuttab R, Robison RA. S2AMN: A potential non- toxic anti-cancer therapy. Annual Meeting of the American Association for Cancer Research. Chicago. 2012 .

Li D, Bills TM, Holt BC, Robison RA, Tolley HD, Lee ML. Differentiation of Closely Related Virulent Bacteria by Thermochemolysis/Methylation and GC-MS. 14th Beijing Conference and Exhibition on Instrumental Analysis. Beijing, China. 2011 .

Dan L, Lee ML, Bills TM, Robison RA, Holt BC, Tolley HD. Differentiation of Closely Related Virulent Bacteria by Thermochemolysis/Methylation and GC-MS. Chemical and Biological Defense Division Annual Conference. Washington, D.C. 2011 .

Robison RA, Bills TM, Li D, Holt B, Tolley HD, Lee ML. Investigation of potential biomarkers of Burkholderia species by thermochemolysis and GC-MS. Burkholderia Workshop. Flagstaff, AZ. 2011 .

Dan L, Truong TV, VanDerwerken DN, Williams JR, Bills TM, Acharya A, Robison RA, Tolley HD, Lee ML. Differentiation of Closely Related Virulent Bacteria by Thermochemolysis/Methylation and GC-MS. 35th International Symposium on Capillary Chromatography. San Diego, CA. 2011 .

Jensen NR, O'Neill KL, Robison RA. CRISPR loci and bacteriophage: a mutually exclusive relationship in pathogenic bacteria. Annual Meeting of the Intermountain Branch of the American Society for Microbiology. Ogden, UT. 2011 .

Engle JM, Robison RA. Phenotypic analysis of M. smegmatis strains resistant to infection by C1 mycobacteriophage “Charlie Brown” provides evidence for identification of glycopeptidolipids as phage receptors. Annual Meeting of the Intermountain Branch of the American Society for Microbiology. Ogden, UT. 2011 .

Lammert SA, Truong TV, Li D, VanDerwerken DN, Williams JR, Taylor CW, Robison RA, Tolley HD, Rands AD, Lee ED, et al. An Automated Sample Preparation System Combined with SPME-GC/MS for the Differentiation of Bacillus Endospores. Pittcon 2011. Atlanta, GA. 2011 .

Truong TV, Li D, VanDerwerken DN, Williams JR, Taylor CW, Robison RA, Tolley HD, Lee ML. Sampling and sample treatment methods for on-site analysis of bacteria using gas chromatography-mass spectrometry. Annual Meeting of The International Chemical Congress of Pacific Basin Societies. Honolulu, Hawaii. 2010 .

Meyers JM, Ryndock E, Conway MJ, Meyers CM, O'Neill KL, Robison RA. The susceptibility of HPV16 native and quasivirus particles to clinically relevant disinfectants. 26th International Papillomavirus Conference. Montreal, Qc, Canada. 2010 .

Bills TM, Shepherd QC, Blam AJ, Moore EA, Gardner JS, Schaalje GB, O'Neill KL, Robison RA. Improved recovery of spores from coated carriers used in the AOAC Sporicidal Activity of Disinfectants (Method II) spore enumeration method, by addition of a surfactant to the rinse solution. General Meeting of the American Society for Microbiology. San Diego, CA. 2010 .

Meyers JM, Ryndock E, Conway MJ, O'Neill KL, Meyers CM, Robison RA. Susceptibility of native and synthetic HPV16 virions to clinical disinfection. General Meeting of the American Society for Microbiology. San Diego, CA. 2010 .

Bills TM, Shepherd QC, Blam AJ, Moore EA, Gardner JS, Schaalje GB, O'Neill KL, Robison RA. Improved recovery of spores from coated carriers used in the AOAC Sporicidal Activity of Disinfectants (Method II) spore enumeration method, by addition of a surfactant to the rinse solution. Intermountain Branch of the American Society for Microbiology Annual Meeting. Provo, UT. 2010 .

Gunnell MK, Carter CD, Jonas WS, Satterfield BA, Moore EA, O'Neill KL, Robison RA. A multiplex real-time PCR assay for the detection and differentiation of Francisella tularensis subspecies. 3rd Annual Biothreat Agent Workshop. Charlotte, NC. 2010 .

Gunnell MK, Carter CD, Jonas WS, Satterfield BA, Moore EA, O'Neill KL, Robison RA. A multiplex real-time PCR assay for the detection and differentiation of Francisella tularensis subspecies. 8th Annual ASM Biodefense and Emerging Disease Research Meeting. Baltimore, MD. 2010 .

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