Hyldahl, Robert

Exercise Sciences

Email: 9{xkq‚umjquIk‚~7nm~  (Email Form)

272  SFH
Provo, UT 84602
(801) 422-1237

Assistant Professor

Curriculum Vitae

 Research Interests
Skeletal muscle is an enormous, fascinating, and spectacularly adaptive organ system, whose vitality has an enormous impact on human health and well-being. Though appreciated most widely for its role in human motor activity, skeletal muscle accounts for over 50% of whole body protein metabolism, 80% of glucose disposal, and is emerging as an exquisitely important endocrine organ. Importantly, epidemiological data have shown quite clearly that reduced skeletal muscle mass and function have widespread deleterious effects on human health including frailty, metabolic dysfunction and mortality. Accordingly, the overarching goal of my laboratory is to contribute in a meaningful way to the development of crucial and much-needed clinical interventions to maintain skeletal muscle vitality through the lifespan by studying the biologic mechanisms that underlie muscle adaptation to stress (e.g. disuse, damage, exercise and injury) in healthy, aged or clinical populations. To achieve this goal, we strive primarily to undertake studies in human skeletal muscle through innovative and novel approaches, supplementing, where appropriate, with mechanistic experiments in relevant animal and in vitro models. Of particular interest are: 1) The role of extracellular matrix remodeling in muscle repair and adaptation to exercise; 2) The effect of externally applied modalities (e.g., heat/cold stress, massage etc.) on muscle metabolic and regenerative function, and their potential as therapeutic interventions; and 3) How inflammation and inflammatory related intracellular signaling affects muscle adaptation and reparative outcomes following exercise and/or injury.

 Education
  • Ph.D., Kinesiology, University of Massachusetts Amherst, 2011
  • M.S., Kinesiology, University of Massachusetts Amherst, 2008
  • B.S., Exercise Science, University of Utah, 2003
 Experience

Professional
  • Assistant Professor, Brigham Young University, 2012-Present
  • Visiting Assistant Professor, University of New Mexico, 2011-2012

 Memberships
  • National Athletic Trainers Association, 2002-Present
 Courses Taught

Winter 2017
  • EXSC 497R: Undergrad Research & Study Section 010
  • EXSC 501: Sports Med Path & Pharm Section 001
  • EXSC 625R: Tissue Response to Injury Section 001
  • EXSC 799R: Doctoral Dissertation Section 003
  • STAC 110: Indoor Cycling Section 014
Fall 2016
  • EXSC 320: Basic Athletic Training Section 001
  • EXSC 497R: Undergrad Research & Study Section 009
  • EXSC 501: Sports Med Path & Pharm Section 001
  • EXSC 797R: Individual Research & Study Section 005
  • EXSC 799R: Doctoral Dissertation Section 004
  • STAC 110: Indoor Cycling Section 015
Summer 2016
  • EXSC 497R: Undergrad Research & Study Section 002
Spring 2016
  • EXSC 497R: Undergrad Research & Study Section 002
  • EXSC 797R: Individual Research & Study Section 001
  • EXSC 799R: Doctoral Dissertation Section 004

Selected Publications

Journal Articles

Hyldahl RD, Gier AM, Evans KC, Eggett DL, Nelson WB, Parcell AC, Deyhle MR. 2016. Skeletal Muscle Inflammation Following Repeated Bouts of Lengthening Contractions in Humans. Frontiers in Physiology. 12(6):424.

LaBarbera KE, Hyldahl RD, O'Fallon KS, Clarkson PM, Witkowski S. 2015. Pericyte NF-kB activation enhances endothelial cell proliferation and proangiogenic cytokine secretion in vitro. Physiol Rep. 3(4). <website> doi:10.14814/phy2.12309

Hyldahl RD, Nelson B, Xin L, Welling T, Groscost L, Hubal MJ, Chipkin S, Clarkson P, Parcell AC. 2015. Extracellular matrix remodeling and its contribution to protective adaptation following lengthening contractions in human muscle. FASEB J. epub ahead of print.

Chen D, Hyldahl RD, Hayward RC. 2015. Creased hydrogels as active platforms for mechanical deformation of cultured cells. Lab on a Chip. 15(4):1160-7.  doi:10.1039/c4lc01296h

Hyldahl RD, Olson T, Welling T, Groscost L, Parcell AC. 2014. Satellite cell activity is differentially affected by contraction mode in human muscle following a work matched bout of exercise. Frontiers in Physiology. 11(5):485. <website>

Hyldahl RD, Hubal MJ. 2014. Lengthening our Perspective: Morphological, Cellular and Molecular Responses to Eccentric Exercise. Muscle and Nerve. 49(2):155-70.

Xin L, Hyldahl RD, Chipkin SR, Clarkson PM. 2013. A contralateral repeated bout effect attenuates induction of NF-κB DNA-binding following eccentric exercise. Journal of Applied Physiology. epub ahead of print.

Hyldahl RD, Schwartz LM, Clarkson PM. 2013. NF-kB activity functions in primary pericytes in a cell and non-cell autonomous manner to affect myotube formation. Muscle and Nerve. 47(4):522-31.

Hyldahl RD, Xin L, Moekel-Cole S, Hubal MJ, Chipkin S, Clarkson PM. 2011. Activation of Nuclear Factor-kB following muscle eccentric contractions in humans is localized primarily to skeletal muscle-residing pericytes. FASEB. 25(9):2956-66.

Hyldahl RD, O'Fallon K, Schwartz LM, Clarkson PM. 2010. Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro model. Journal of Applied Physiology. 109(5):1515-23.

Hyldahl RD, Keadle J, Rouzier PA, Pearl D, Clarkson PM. 2010. Effects of Ibuprofen Topical Gel on Muscle Soreness. Medicine and Science in Sports and Exercise. 42(3):614-21.

Presentations

Hyldahl RD. Mechanisms of the Skeletal Muscle Repeated Bout Effect. Southwest Chapter of ACSM Annual Meeting. Costa Mesa, CA. 2017 .

Hyldahl RD, Nosaka K, Howatson G, Hubal M. Mechanisms of the Skeletal Muscle Repeated Bout Effect. ACSM National Meeting. Denver, CO. 2017 .

Preece C, Deyhle M, Sorensen JR, Parmley J, Hafen P, Robison M, Hyldahl RD. Role of the cytokine IP-10 in skeletal muscle regeneration. Southwest Chapter of ACSM Annual Meeting. Costa Mesa, CA. 2016 .

Groscost L, Sorensen JR, Holland A, Hyldahl RD. Tenascin C expression in old and young human skeletal muscle in response to damaging exercise. Southwest Chapter of ACSM Annual Meeting. Costa Mesa, CA. 2016 .

Twitchell A, Hafen P, Parmley J, Hyldahl RD. The effect of IP-10 on the differentiation of human primary myoblasts. Southwest Chapter of ACSM Annual Meeting. Costa Mesa, CA. 2016 .

Seeley MK, Evans A, Hyldahl RD, Kwon S, Ridge SE, Robinson E, Hopkins JT. Decreased intra-articular inflammation of the knee and mechanical load due to running. American Society of Biomechanics Annual Meeting. 2016 .

Evans A, Ridge SE, Hyldahl RD, Kwon S, Hopkins JT, Robinson E, Seeley MK. The effect of running ground reaction force on serum and knee synovial fluid cartilage oligomeric matrix protein. American Society of Biomechanics Annual Meeting. 2016 .

Hyldahl RD. Understanding Skeletal Muscle Regeneration: Implications for Management of Muscle Injuries. NATA Annual Meeting. Baltimore, MD. 2016 .

Deyhle MR, Evans K, Sorensen J, Hyldahl RD. T-cells infiltrate healthy skeletal muscle after exertional damage to a greater extent in women. Advances in Skeletal Muscle Biology in Health and Disease Conference. Gainsville, FL. 2016 .

Hyldahl RD. Examining muscle physiology using the experimental coninuum: from hypertrophy to atrophy. ACSM Southwest Chapter. Costa Mesa, CA. 2015 .

Hyldahl RD. Mechanisms of the Repeated Bout Effect: Role of the Extracellular Matrix. Southwest Chapter of ACSM Annual Meeting. Costa Mesa, CA. 2014 .

Hyldahl RD. Attenuation of the Inflammatory Response Following Skeletal Muscle Injury: Constructive or Destructive. Rocky Mountain Athletic Trainers Association Annual Meeting. Provo, UT. 2014 .

Hyldahl RD. “Skeletal Muscle Structure/Function – Exercise and the Satellite Cell Response,”. Southwest Chapter of ACSM. Newport Beach, CA. 2013 .

Hyldahl RD. Molecular Mechanisms of Exertional Rhabdomyolysis. UMass Sports Medicine Training Conference. Amherst, MA. 2011 .

Hyldahl RD. A Primer on Methods in Genomic Research. New England Chapter of ACSM National Meeting. Providence, RI. 2008 .

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