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David A. McClellan

Personal Information

David A. McClellan
Biology
Email: David_McClellan@byu.edu

699 WIDB
Provo, UT 84602
(801) 422-8059

Assistant Professor

  • 1999 - Doctor of Philosophy, Louisiana State University, Department of Biological Sciences and Museum of Natural Science, Baton Rouge, Louisiana, USA (Mark S. Hafner, major advisor). Thesis: “Null codon-based models of synonymous and nonsynonymous substitution from a phylogenetic perspective.” Research Emphasis: Evolutionary bioinformatics and proteomics; construction of mathematical and statistical models of molecular evolution; molecular adaptation of cytochrome b.
  • 1994 - Master of Science, Brigham Young University, Department of Zoology (Duke S. Rogers, major advisor). Thesis: “Segregation of random amplified polymorphic DNA (RAPD) and microsatellite markers in backcross progeny of Peromyscus.” Research Emphasis: Genetics and molecular evolution of deer mice (genus Peromyscus).
  • 1991 - Bachelor of Science, Brigham Young University, Department of Zoology (Duke S. Rogers, major advisor). Academic Emphasis: Evolutionary science.

Postdoctoral Ecperience:
Japan Society for the Promotion of Science Postdoctoral Fellow. The Institute of Statistical Mathematics, Tokyo (Masami Hasegawa, supervisor), and the Tokyo Institute Technology, Graduate Campus, Yokohama (Norihiro Okada, supervisor). Research Emphasis: Theoretical modeling of molecular evolution from a phylogenetic perspective (nucleotide substitutional dynamics and patterns of amino acid replacement with special emphasis on selective influences on physicochemical properties) and its application to evolutionary bioinformatics.

Background:
  • Born in Las Vegas, Nevada, USA, 8 October 1966
  • Married to Lynda Mickelsen, 28 October 1988
  • Four children: Amanda (15 years), Davis (13 years), Evan (5 years), and Daniel (2 years)
  • Present address: Dept. Integrative Biology, 699 WIDB, BYU, Provo, Utah 84602, USA
  • Home address: 455 North 800 East, Orem, Utah 84097, USA
  • Fax: (801) 422-0090

McClellan Lab Software Download Page

 Education
  • PhD , Biological Sciences , Louisiana State University , 1999
  • MS , Zoology , BYU , 1994
  • BS , Zoology , BYU , 1991
 Research

Theoretical aspects of protein and DNA molecular evolution. This includes mathematical and statistical modeling, software and other methodology development, and empirical analysis of protein-coding gene sequences.

 Selected Publications

Articles

Porter, M. L., T. Cronin, D. A. McClellan, and K. A. Crandall.  "Molecular characterization of crustacean visual pigments and the evolution of pancrustacean opsins."  Molecular Biology and Evolution.  24 (2007): 253-268. 

Perez-Losada, M., R. G. Christensen, D. A. McClellan, B. J. Adams, R. P. Viscidi, and K. A. Crandall.  "Comparing phylogenetic codivergence between polyomaviruses and their hosts."  Journal of Virology.  80 (2006): 5663-5669. 

Ebbert, M. T. W., T. D. O'Connor, W. A. Beckstead, M. J. Clement, and D. A. McClellan.  "Pharmacogenomics: Analyzing SNPs in the CYP2D6 gene using amino acid properties."  Proceedings of the Biotechnology and Bioinformatics Symposium.  3 (2006): 1-5. 

Baer, K. and D. A. McClellan.  "Molecular coevolution of the vertebrate cytochrome c1 and Rieske iron sulfer proteins in the cytochrome bc1 complex."  Proceedings of the Biotechnology and Bioinformatics Symposium.  3 (2006): 10-18. 

Chamala, S., W. A. Beckstead, M. J. Rowe, and D. A. McClellan.  "Evolutionary selective pressure on three mitochondrial SNPs is consistent with their influence on metabolic efficiency in Pima Indians."  Proceedings of the Biotechnology and Bioinformatics Symposium.  3 (2006): 35-44. 

Smith, R. L., S. A. Loughmiller, and D. A. McClellan.  "Analysis of the effects of positive selection on physicochemical properties in the nicotinic acetylcholine receptor and associated structural implications."  Proceedings of the Biotechnology and Bioinformatics Symposium.  3 (2006): 112-115. 

Porter, M. L., T. W. Cronin, D. A. McClellan, and K. A. Crandall.  "The molecular evolution of invertebrate opsins."  Investigative Ophthalmology & Visual Science.  47.E-Abstract (2006): 3748. 

A. C. Edmondson, D. Song, L. A. Alvarez, M. K. Wall, D. Almond, DAVID A. McCLELLAN, A. Maxwell, and B. L. Nielsen.  "Characterization of an Arabidopsis thaliana mitochondrial-targeted single-stranded DNA binding protein."  Molecular and General Genomics.  273 (2005): 115-122. 

DAVID A. McCLELLAN, J. L. Moss, E. J. Palfreyman, M. J. Smith, R. G. Christensen, and J. K. Sailsbery.  "Physicochemical evolution and molecular adaptation of the cetacean cytochrome b protein."  Molecular Biology and Evolution.  22 (2005): 437-455. 

McClellan, D. A., D. F. Whiting, R. G. Christensen, and J. K. Sailsbery.  "Genetic codes as evolutionary filters: Subtle differences in the structures of genetic codes result in significant differences in patterns of nucleotide substitution."  Journal of Theoretical Biology.  226:393-400 (2004). 

Wooley, S., M. Smith, J. Johnson, D. A. McClellan, K. A. Crandall.  "Tree SAAP: Selection on Amino Acid Properties using phylogenetic trees."  Bioinformatics.  19 (2003): 671-672. 

DAVID A. McCLELLAN.  "Detecting Lehi's genetic signature."  FARMS Review.  15 (2003): 35-90. 

McClellan, D. A. and K. G. McCracken.  "Estimating the influence of selection on the variable amino acid sites of the cytochrome b protein functional domains."  Molecular Biology and Evolution.  18 (2001): 917-925. 

McClellan, D. A.  "The codon-degeneracy model of molecular evolution."  Journal of Molecular Evolution.  50 (2000): 131-140. 

McClellan, D. A.  "The phylogenetic utility of the codon-degeneracy model."  Journal of Molecular Evolution.  51 (2000): 185-193. 

McCracken, K. G., J. Harshman, D. A. McClellan, and A. D. Afton.  "Data set incongruence and correlated character evolution: an example of functional convergence in the hind-limbs of stifftail diving ducks."  Systematic Biology.  48 (1999): 36-68. 

Books

M. Perez-Losada, DAVID A. McCLELLAN, R. G. Christensen, R. P. Viscidi, and K. A. Crandall.  Phylogenomics and molecular evolution of polyomaviruses. In: Polyomavirus and Human Diseases.  Ed. N. Ahsan.  1st ed.  Georgetown, Texas: Landes Bioscience, Mar. 2005. 

 Experience

General

  • Assistant Professor , BYU Dept. Integrative Biology , 2002-Present
  • Assistant Professor , BYU Dept. Zoology , 2001-2001
  • Postdoctoral Fellow , Tokyo Institute of Technology , 1999-2000
  • Postdoctoral Fellow , The Institute of Statistical Mathematics , 1999-2000

 Awards
  • Publisher's Award for Excellence in Systematic Research , Taylor and Francis, Inc. , 2000
  • American Society of Mammalogists Honoraria , American Society of Mammalogists , 1997
 Courses Taught
Science of Biology Biology 120 Intermittent
Evolutionary Biology Biology 420 Fall Semesters
Bioinformatics InBio 465 Odd-year Fall Semesters
Molecular Evolution InBio 641 Even-year Winter Semesters
Biology | Microbiology & Molecular Biology | Nutrition, Dietetics & Food Science | Physiology & Developmental Biology | Plant & Wildlife Sciences
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