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Sterling Sudweeks Physiology & Developmental Biology Email: Sterling_Sudweeks@byu.edu 595 WIDB Associate Professor
Postdoctoral fellowship, National Institute of Environmental Health Sciences/NIH. Research Triangle Park, North Carolina. 1997-2001. Description of Research: Ligand-gated ion channels are neurotransmitter receptors involved in synaptic transmission. These receptors act as “ion channels” across the neuronal membrane and are implicated in several pathological conditions (e.g., epilepsy, Alzheimer’s disease, Parkinson’s disease, motor disorders, and schizophrenia, to name a few). They are also the pharmacological targets in many therapeutic situations (e.g., many general anesthetics, sedatives, antiemetics, and even some novel analgesics). These ion channels are multi-subunit protein complexes expressed by neurons in the central and peripheral nervous systems (CNS and PNS respectively). My research focuses on how ligand-gated ion channel physiology is modulated by gene expression. I usually have about 10 students working in my lab, the majority of them are biophysics, PDBio, and neuroscience majors. Techniques that I use in my lab to study these neurotransmitter receptors include patch-clamp electrophysiology, transfection of DNA into heterologous expression systems, and single-cell quantitative RT-PCR.
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Molecular and Biophysical Characterization of Ligand-gated Ion Channels in the Central Nervous System |
| Selected Publications |
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Articles Ludlow KH, Bradley KD, Allison DW, Taylor SR, Yorgason JT, Hansen DM, Walton CH, Sudweeks SN, Steffensen SC. "Acute and chronic ethanol modulate dopamine D2-subtype receptor responses in ventral tegmental area GABA neurons." Alcoholism: Clinical and Experimental Research. 33.5 (2009): 804-811. <website> Branvold DJ, Allred DR, Beckstead DJ, Kim HJ, Fillmore N, Condon BM, Brown JD, Sudweeks SN, Thomson DM, Winder WW. "Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle." Journal of Applied Physiology. 105.4 (2008): 1218-1227. <website> Seegmiller RE, Bomsta BD, Bridgewater LC, Niederhauser CM, Montaño C, Sudweeks S, Eyre DR, Fernandes RJ. "The heterozygous disproportionate micromelia (dmm) mouse: morphological changes in fetal cartilage precede postnatal dwarfism and compared with lethal homozygotes can explain the mild phenotype." The Journal of Histochemistry & Cytochemistry. 56.11 (2008): 1003-1011. <website> Allison DW, Ohran AJ, Stobbs SH, Mameli M, Valenzuela CF, Sudweeks SN, Ray AP, Henriksen SJ, Steffensen SC. "Connexin-36 gap junctions mediate electrical coupling between ventral tegmental area GABA neurons." Synapse. 60.1 (2006): 20-31. <website> 8. Wilson-Ashworth, H.A., Judd, A.M., Law, R.M., Freestone, B.D., Taylor, S., Mizukawa, M.K., Cromar, K.R., SUDWEEKS S., and Bell, J.D. "Formation of transient non-protein calcium pores by lysophospholipids in S49 lymphoma cells." The Journal of Membrane Biology. 200.1 (2004): 25-33. <website> E. B. Taylor, D. Hurst, L. J. Greenwood, J. D. Lamb, T. D. Cline, S. N. SUDWEEKS, and W. W. Winder. "Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle." American Journal of Physiology: Endocrinol Metab. 287 (2004): E1082-E1089. <website> SUDWEEKS S.N., Hooft J.A., Yakel J.L. "Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterization." Journal of Physiology. 544.3 (2002): 715-726. <website> Khiroug, S.S., Harkness, P.C., Lamb, P.W., SUDWEEKS, S., Khiroug, L., Millar, N.S., and Yakel, J.L. "Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels." Journal of Physiology. 540.2 (2002): 425-434. <website> SUDWEEKS, S., and Yakel, J.L. "Functional and Molecular Characterization of Neuronal Nicotinic ACh Receptors in Rat CA1 Hippocampal Neurones." Journal of Physiology. 527.3 (2000): 515-528. <website> Kriegler, S., SUDWEEKS, S., and Yakel, J.L. "MTSEA potentiates 5-HT3 receptors containing the nicotinic alpha4 subunit." Neuropharmacology. 22.12 (1999): 555-561. <website> Kriegler, S., Sudweeks, S., and Yakel J.L. "The nicotinic alpha4 receptor subunit contributes to the lining of the ion channel pore when expressed with the 5-HT3 receptor subunit." Journal of Biological Chemistry. 274.7 (1999): 3934-6. <website> Jones, S., SUDWEEKS, S., and Yakel, J.L. "Nicotinic receptors in the brain: correlating physiology with function." Trends in Neurosciences. 22.12 (1999): 555-561. <website> SUDWEEKS, S.N., and Twyman, R.E. "Single Cell Reverse-Transcription Polymerase Chain Reaction (RT-PCR) and the GABA-A Receptor." Neurochemistry International. 28.2 (1996): 137-139. |
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| Courses Taught |
| PDBio 362: Advanced Physiology PDBio 363: Advanced Physiology Laboratory PDBio 365: Pathophysiology PDBio 568: Biophysics |
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