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David D. Busath Physiology & Developmental Biology Email: David_Busath@byu.edu 549B WIDB Professor Home Page |
| Education |
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| Research |
Molecular biophysics of membrane proteins, focusing on ion channels including gramicidin, influenza M2, botulinum toxin heavy chain, and connexin36 |
| Selected Publications |
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Articles Miller, C.E. D.D. Busath, B. Strongin, and J. Majewski. "Integration of Ganglioside GT1b Receptor into DPPE and DPPC Phospholipid Monolayers: An X-ray Reflectivity and Grazing Incidence Diffraction Study." Biophysical Journal. 95 (2008): 3278-3286. Moffatt, C., V. Vijayvergiya, P.F. Gao, T.A. Cross, D.J. Woodbury, and D.D. Busath. "Proton transport through influenza A virus M2 protein reconstituted in vesicles." Biophysical Journal. 94 (2008): 434-445. Hu, J., R. Fu, K. Nishimura, L. Zhang, H.-X. Zhou, D. D. Busath, V. Vijayvergiya and T.A. Cross. "Histidines: Heart of the H+ channel from influenza A virus." Proceedings of the National Academy of Sciences, USA. 103 (2006): 6865-6870. J.D. Durrant, D. Caywood, and D.D. Busath. "Tryptophan contributions to the empirical free-energy profile in gramicidin A/M heterodimer channels." Biophysical Journal. 91 (2006): 3230-3241. Boda, D., T. Varga, D. Henderson, D.D. Busath, W. Nonner, D. Gillespie, and B. Eisenberg. "Monte Carlo simulation study of a system with a dielectric boundary: Application to ion channel selectivity." Molecular Simulation. 30 (2004): 89-96. Yang, Y., D. Henderson, and D.D. Busath. "Calcium block of sodium current in a model calcium channel: Cylindrical atomistic pore with glutamate side chains." Molecular Simulation. 30 (2004): 77-80. Ramakrishnan, V. and Busath, D.D. "Applied field nonequilibrium molecular dynamics simulations of ion exit from a beta-barrel model of the L-type calcium channel." Biochim Biophys Acta. 1664 (2004): 1-8. Hughes, T., B. Strongin, F.P. Gao, Va. Vijayvergiya, D.D. Busath, and R.C. Davis. "AFM visualization of mobile influenza A M2 molecules in planar bilayers." Biophysical Journal. 87 (2004): 311-22. Vijayvergiya, V., R. Wilson, A. Chorak, P.F. Gao, T.A. Cross, and D.D. Busath. "Proton conductance of influenza virus m2 protein in planar lipid bilayers." Biophysical Journal. 87 (2004): 1697-1704. Yang, Y., M. Berrondo, D. Henderson, and D. Busath. "The importance of water molecules in ion channel simulations." J. Phys.: Condens. Matter. 16 (2004): S2145-S2148. D.D. Busath, D. Henderson, and S. SokoBowski. "Density functional theory for an electrolyte in a cylinder: The selectivity of the calcium channel." J. Phys.: Condens. Matter. 16 (2004): S2193-S2201. Duffin, R.L., Garrett, M.P., Flake, K.B., Durrant, J.D., and D. D. Busath. "Modulation of lipid bilayer interfacial dipole potential by phloretin, RH421, and 6-ketocholestanol as probed by gramicidin channel conductance." Langmuir. 19 (2003): 1439-1442. Yang, Y., D. Henderson, and D.D. Busath. "Applied-field molecular dynamics study of a model calcium channel selectivity filter." J. Chem. Phys. 118 (2003): 4213-4220. Bingham, N.C., N.E.C. Smith, T.A. Cross, and D.D. Busath. "Molecular dynamics simulations of Trp side-chain conformational flexibility in the gramicidin A channel." Biopolymers. 71 (2003): 593-600. Dezso Boda, Tibor Varga, Douglas Henderson, David D. Busath, Dirk Gillespie, Wolfgang Nonner, and Bob Eisenberg. "Monte Carlo simulation of ion channels using different dielectric domains." Physics of Liquid Matter: Modern Problems (PLMMP). Sep. 2003. Cole, C. D., A. S. Frost, N. Thompson, M. Cotten, T. A. Cross, and D. D. Busath. "Non-contact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents." Biophys J. 83 (2002): 1974-1986. Ramakrishnan, V. and D. D. Busath. "An inverting basket model for Band 3 obligate exchange." Journal of Theoretical Biology. 215 (2002): 215-226. Gowen, J.A. J.C. Markham, S.E. Morrison, D.D. Busath, T.A. Cross, E.J. Mapes, and M.F. Schumaker. "The role of Trp side chains in tuning single proton conduction through gramicidin channels." Biophysical Journal. 83 (2002): 880-898. Yang, Y., D. Henderson, P. Crozier, R.L. Rowley, and D.D. Busath. "Permeation of ions through a model biological channel: Effect of periodic boundary conditions and cell size." Molecular Physics. 100 (2002): 3011-3019. Boda, D., D. Henderson, and D.D. Busath. "Monte Carlo study of the selectivity of calcium channels: Improved geometrical model." Molecular Physics. 100 (2002): 2361-2368. Boda, D., D.D. Busath, B. Eisenberg, D. Henderson, and W. Nonner. "Monte Carlo simulations of selectivity in neuronal Na channels: Charge space competition." Phys. Chem. Chem. Phys. 4 (2002): 5154-5160. Fu, F.-N., D.D. Busath, and B.R. Singh. "Spectroscopic analysis of low pH and lipid induced structural changes in type A botulinum neurotoxin relevant to membrane channel formation and translocation." Biophys Chem. 99 (2002): 17. Yang, Y., Boda, D., Henderson, D. and D. Busath. "Computer simulation studies of the selectivity and conductance of a model calcium channel." Journal of Computational Electronics. 1 (2002): 353-357. Caywood, D. and D.D. Busath. "Oriented Gramicidin M - Gramicidin A heterodimers: Rectification decreases with increased ion concentration. In Membrane Interacting Peptides and Proteins 2002." Heitz, ed. Research Signpost , Kerala, India. 2002: 147-153. Anderson, D.G., R.B. Shirts, T.A. Cross, and D.D. Busath. "Non-contact dipole effects on channel permeation. V. Computed potentials for fluorinated gramicidin." Biophys. J. 81 (2001): 1255-1264. Crozier, P.S., R.L. Rowley, N.B. Holladay, D. Henderson, and D.D. Busath. "Molecular dynamics simulation of continuous current flow through a model biological membrane channel." Physics Review Letters. 86 (2001): 2467-2470. Boda, D., D. Henderson, and D.D. Busath. "Monte Carlo study of the effect of ion and channel size on the selectivity of a model calcium channel." J. Physical Chemistry B. 105 (2001): 11574-11577. Markham, J.C., J.A. Gowen, T.A. Cross, and D.D. Busath. "Comparison of gramicidin A and gramicidin M channel conductance dispersion properties." Biochimica et Biophysica Acta. 1513 (2001): 185-192. Cole, C. D., A. S. Frost, N. Thompson, M. Cotten, T. A. Cross, and D. D. Busath. "Non-contact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents." Biophys J. 83 (2001): 1974-1986. Hollerbach, U., Chen, D.P., Busath, D. D., and Eisenberg, B. "Predicting function from structure using the Poisson-Nernst-Planck equations: sodium current in the gramicidin A channel." Langmuir. 16 (2000): 5509-5514. Dorigo, A.E., Anderson, D.G., and Busath, D.D. "Noncontact dipole effects on channel permeation. II. Trp conformations and dipole potentials in gramicidin A." Biophysical Journal. 76 (1999): 1897-1908. Andersen, O.S., H.J. Appell, E.Bamberg, D.D. Busath, R.E. Koeppe II, F.J. Sigworth, G. Szabo, D.W. Urry, and A. Woolley. "Gramicidin Channel Controversy -- The Structure in a Lipid Environment." Nature Structural Biology. 6 (1999): 609-611. Cotten, M., C. Tian, D.D. Busath, R.B. Shirts, and T.A. Cross. "Modulating Dipoles for Structure-Function Correlations in the Gramicidin A Channel." Biochemistry. 38 (1999): 9185-9197. Phillips, L.R., C.D. Cole, R.J. Hendershot, M. Cotten, T.A. Cross, and D.D. Busath. "Noncontact dipole effects on channel permeation. III. Anomalous proton conductance effects in gramicidin." Biophysical Journal. 77 (1999): 2492-2501. Fairbanks, T.G., C.L. Andrus, and D.D. Busath. "Lorentzian Noise in Single Gramicidin A Channel Formarmidinium Currents. In. Gramicidin and Related Ion Channel-Forming Peptides." Novartis Foundation Symposium 225. 1999. |
| Experience |
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General
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| Awards |
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| Courses Taught |
| PDBio 220 Human Anatomy. Winter semester and summer term.
PDBio 362 Advanced Physiology. Winter semester. PDBio 568 Cellular Electrophysiology and Biophysics. Fall semester. |