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David D. Busath

Personal Information

David D. Busath
Physiology & Developmental Biology
Email: David_Busath@byu.edu

549B WIDB
Provo, UT 84602
(801) 422-8753

Professor

Home Page

 Education
  • MD , , University of Utah , 1978
  • BA , Physics , University of Utah , 1974
 Research

Molecular biophysics of membrane proteins, focusing on ion channels including gramicidin, influenza M2, botulinum toxin heavy chain, and connexin36

 Selected Publications

Articles

Miller, C.E. D.D. Busath, B. Strongin, and J. Majewski.  "Integration of Ganglioside GT1b Receptor into DPPE and DPPC Phospholipid Monolayers: An X-ray Reflectivity and Grazing Incidence Diffraction Study."  Biophysical Journal.  95 (2008): 3278-3286. 

Moffatt, C., V. Vijayvergiya, P.F. Gao, T.A. Cross, D.J. Woodbury, and D.D. Busath.  "Proton transport through influenza A virus M2 protein reconstituted in vesicles."  Biophysical Journal.  94 (2008): 434-445. 

Hu, J., R. Fu, K. Nishimura, L. Zhang, H.-X. Zhou, D. D. Busath, V. Vijayvergiya and T.A. Cross.  "Histidines: Heart of the H+ channel from influenza A virus."  Proceedings of the National Academy of Sciences, USA.  103 (2006): 6865-6870. 

J.D. Durrant, D. Caywood, and D.D. Busath.  "Tryptophan contributions to the empirical free-energy profile in gramicidin A/M heterodimer channels."  Biophysical Journal.  91 (2006): 3230-3241. 

Boda, D., T. Varga, D. Henderson, D.D. Busath, W. Nonner, D. Gillespie, and B. Eisenberg.  "Monte Carlo simulation study of a system with a dielectric boundary: Application to ion channel selectivity."  Molecular Simulation.  30 (2004): 89-96. 

Yang, Y., D. Henderson, and D.D. Busath.  "Calcium block of sodium current in a model calcium channel: Cylindrical atomistic pore with glutamate side chains."  Molecular Simulation.  30 (2004): 77-80. 

Ramakrishnan, V. and Busath, D.D.  "Applied field nonequilibrium molecular dynamics simulations of ion exit from a beta-barrel model of the L-type calcium channel."  Biochim Biophys Acta.  1664 (2004): 1-8. 

Hughes, T., B. Strongin, F.P. Gao, Va. Vijayvergiya, D.D. Busath, and R.C. Davis.  "AFM visualization of mobile influenza A M2 molecules in planar bilayers."  Biophysical Journal.  87 (2004): 311-22. 

Vijayvergiya, V., R. Wilson, A. Chorak, P.F. Gao, T.A. Cross, and D.D. Busath.  "Proton conductance of influenza virus m2 protein in planar lipid bilayers."  Biophysical Journal.  87 (2004): 1697-1704. 

Yang, Y., M. Berrondo, D. Henderson, and D. Busath.  "The importance of water molecules in ion channel simulations."  J. Phys.: Condens. Matter.  16 (2004): S2145-S2148. 

D.D. Busath, D. Henderson, and S. SokoBowski.  "Density functional theory for an electrolyte in a cylinder: The selectivity of the calcium channel."  J. Phys.: Condens. Matter.  16 (2004): S2193-S2201. 

Duffin, R.L., Garrett, M.P., Flake, K.B., Durrant, J.D., and D. D. Busath.  "Modulation of lipid bilayer interfacial dipole potential by phloretin, RH421, and 6-ketocholestanol as probed by gramicidin channel conductance."  Langmuir.  19 (2003): 1439-1442. 

Yang, Y., D. Henderson, and D.D. Busath.  "Applied-field molecular dynamics study of a model calcium channel selectivity filter."  J. Chem. Phys.  118 (2003): 4213-4220. 

Bingham, N.C., N.E.C. Smith, T.A. Cross, and D.D. Busath.  "Molecular dynamics simulations of Trp side-chain conformational flexibility in the gramicidin A channel."  Biopolymers.  71 (2003): 593-600. 

Dezso Boda, Tibor Varga, Douglas Henderson, David D. Busath, Dirk Gillespie, Wolfgang Nonner, and Bob Eisenberg.  "Monte Carlo simulation of ion channels using different dielectric domains."  Physics of Liquid Matter: Modern Problems (PLMMP).  Sep. 2003. 

Cole, C. D., A. S. Frost, N. Thompson, M. Cotten, T. A. Cross, and D. D. Busath.  "Non-contact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents."  Biophys J.  83 (2002): 1974-1986. 

Ramakrishnan, V. and D. D. Busath.  "An inverting basket model for Band 3 obligate exchange."  Journal of Theoretical Biology.  215 (2002): 215-226. 

Gowen, J.A. J.C. Markham, S.E. Morrison, D.D. Busath, T.A. Cross, E.J. Mapes, and M.F. Schumaker.  "The role of Trp side chains in tuning single proton conduction through gramicidin channels."  Biophysical Journal.  83 (2002): 880-898. 

Yang, Y., D. Henderson, P. Crozier, R.L. Rowley, and D.D. Busath.  "Permeation of ions through a model biological channel: Effect of periodic boundary conditions and cell size."  Molecular Physics.  100 (2002): 3011-3019. 

Boda, D., D. Henderson, and D.D. Busath.  "Monte Carlo study of the selectivity of calcium channels: Improved geometrical model."  Molecular Physics.  100 (2002): 2361-2368. 

Boda, D., D.D. Busath, B. Eisenberg, D. Henderson, and W. Nonner.  "Monte Carlo simulations of selectivity in neuronal Na channels: Charge space competition."  Phys. Chem. Chem. Phys.  4 (2002): 5154-5160. 

Fu, F.-N., D.D. Busath, and B.R. Singh.  "Spectroscopic analysis of low pH and lipid induced structural changes in type A botulinum neurotoxin relevant to membrane channel formation and translocation."  Biophys Chem.  99 (2002): 17. 

Yang, Y., Boda, D., Henderson, D. and D. Busath.  "Computer simulation studies of the selectivity and conductance of a model calcium channel."  Journal of Computational Electronics.  1 (2002): 353-357. 

Caywood, D. and D.D. Busath.  "Oriented Gramicidin M - Gramicidin A heterodimers: Rectification decreases with increased ion concentration. In Membrane Interacting Peptides and Proteins 2002."  Heitz, ed. Research Signpost , Kerala, India.  2002: 147-153. 

Anderson, D.G., R.B. Shirts, T.A. Cross, and D.D. Busath.  "Non-contact dipole effects on channel permeation. V. Computed potentials for fluorinated gramicidin."  Biophys. J.  81 (2001): 1255-1264. 

Crozier, P.S., R.L. Rowley, N.B. Holladay, D. Henderson, and D.D. Busath.  "Molecular dynamics simulation of continuous current flow through a model biological membrane channel."  Physics Review Letters.  86 (2001): 2467-2470. 

Boda, D., D. Henderson, and D.D. Busath.  "Monte Carlo study of the effect of ion and channel size on the selectivity of a model calcium channel."  J. Physical Chemistry B.  105 (2001): 11574-11577. 

Markham, J.C., J.A. Gowen, T.A. Cross, and D.D. Busath.  "Comparison of gramicidin A and gramicidin M channel conductance dispersion properties."  Biochimica et Biophysica Acta.  1513 (2001): 185-192. 

Cole, C. D., A. S. Frost, N. Thompson, M. Cotten, T. A. Cross, and D. D. Busath.  "Non-contact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents."  Biophys J.  83 (2001): 1974-1986. 

Hollerbach, U., Chen, D.P., Busath, D. D., and Eisenberg, B.  "Predicting function from structure using the Poisson-Nernst-Planck equations: sodium current in the gramicidin A channel."  Langmuir.  16 (2000): 5509-5514. 

Dorigo, A.E., Anderson, D.G., and Busath, D.D.  "Noncontact dipole effects on channel permeation. II. Trp conformations and dipole potentials in gramicidin A."  Biophysical Journal.  76 (1999): 1897-1908. 

Andersen, O.S., H.J. Appell, E.Bamberg, D.D. Busath, R.E. Koeppe II, F.J. Sigworth, G. Szabo, D.W. Urry, and A. Woolley.  "Gramicidin Channel Controversy -- The Structure in a Lipid Environment."  Nature Structural Biology.  6 (1999): 609-611. 

Cotten, M., C. Tian, D.D. Busath, R.B. Shirts, and T.A. Cross.  "Modulating Dipoles for Structure-Function Correlations in the Gramicidin A Channel."  Biochemistry.  38 (1999): 9185-9197. 

Phillips, L.R., C.D. Cole, R.J. Hendershot, M. Cotten, T.A. Cross, and D.D. Busath.  "Noncontact dipole effects on channel permeation. III. Anomalous proton conductance effects in gramicidin."  Biophysical Journal.  77 (1999): 2492-2501. 

Fairbanks, T.G., C.L. Andrus, and D.D. Busath.  "Lorentzian Noise in Single Gramicidin A Channel Formarmidinium Currents. In. Gramicidin and Related Ion Channel-Forming Peptides."  Novartis Foundation Symposium 225.  1999. 

 Experience

General

  • Professor , BYU , 1996-Present
  • Associate Professor , BYU , 1995-1996
  • Associate Professor , Brown University , 1989-1995
  • Assistant Professor , Brown University , 1983-1989
  • Research Associate , Univ. of Texas, Medical Branch , 1980-1983
  • Postdoctoral Fellow , Univ. of Rochester , 1978-1980

 Awards
  • Thomas Martin Professorship , BYU , 2003
  • Research Award , College of Biology and Agriculture , 2002
  • Alcuin Fellowship for General Education Teaching , BYU , 2001
  • Research Career Development Award , Brown University , 1991
  • Markey Fellow , Mount Dessert Island Biological Laboratory , 1985
 Courses Taught
PDBio 220 Human Anatomy. Winter semester and summer term.

PDBio 362 Advanced Physiology. Winter semester.

PDBio 568 Cellular Electrophysiology and Biophysics. Fall semester.

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