The College of Life Sciences

Bridgewater, Laura

Microbiology & Molecular Biology

Email: 3odxudbeulgjhzdwhuCe|x1hgx  (Email Form)

Website: http://bridgewaterlab.byu.edu

3141  LSB
Provo, UT 84602
(801) 422-2434

Associate Professor

Curriculum Vitae

 Teaching Interests
Molecular Biology, Gene Regulation, Genes and Cancer
 Research Interests
The primary focus of research in the Bridgewater Lab is the novel nuclear variant of BMP2, which we discovered in 2010 and named nBMP2. BMP2 has previously been recognized as a secreted growth factor that participates in bone and cartilage formation, limb formation, patterning, heart development, and apoptosis. We have discovered another form of BMP2 that is translated from the same mRNA transcript but from an alternative downstream start codon, which eliminates the signal peptide and thus prevents trafficking through the endoplasmic reticulum (ER) and Golgi. Instead, translation occurs in the cytoplasm and a nuclear localization signal directs translocation to the nucleus. We have generated a “knock-in” mouse line in which nuclear translocation of nBMP2 is blocked while secreted BMP2 is produced normally. Preliminary studies on this mouse line suggest that nBMP2 affects skeletal muscle contractions, learning and memory, cell cycle progression, and spleen development. Each of these areas has thus become a target of ongoing research in the lab.
 Courses Taught

Summer 2014
  • LFSCI 399R: Academic Internship Section 006
  • MMBIO 240: Molecular Biology Section 002
  • MMBIO 551R: Microbial Ecology Section 001
Winter 2014
  • BIO 662: Genomics, Mol Evol, Devel Bio Section 001
  • IAS 201R: Cultural Survey Section 034
  • MMBIO 390R: Readings in Molecular Biology Section 001
  • MMBIO 494R: Mentored Research Section 003
  • MMBIO 662: Genomics, Mol Evol, Devel Bio Section 001
  • PDBIO 662: Genomics, Mol Evol, Devel Bio Section 001
Fall 2013
  • BIO 661: Molecular Biology of the Cell Section 001
  • MMBIO 240: Molecular Biology Section 004
  • MMBIO 494R: Mentored Research Section 003
  • MMBIO 661: Molecular Biology of the Cell Section 001
  • PDBIO 661: Molecular Biology of the Cell Section 001
Summer 2013
  • MMBIO 494R: Mentored Research Section 002
  • MMBIO 699R: Master's Thesis Section 002
  • MMBIO 799R: Dissertation Section 001

Selected Publications
Journal Articles

Bridgewater LC, Mayo JL, Evanson BG, Whitt ME, Dean SA, Yates JD, Holden DN, Schmidt AD, Fox CL, Dhunghel S, et al. A novel bone morphogenetic protein 2 mutant mouse, nBmp2NLStm, displays impaired intracellular Ca2+ handling in skeletal muscle. BioMed Research International. 2013 Nov;2013. <website>

Ricks ML, Farrell JT, Falk DJ, Holt DW, Rees M, Carr J, Williams T, Nichols BA, Bridgewater LC, Reynolds PR, et al. Osteoarthritis in Temporomandibular Joint of Col2a1 Mutant Mice. Archives of Oral Biology. 2013 Aug;58(9):1092-9.

Holt DW, Henderson ML, Stockdale CE, Ferrell JT, Kooyman DL, Bridgewater LC, Seegmiller RE. Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis. Ostoeoarthritis and Cartilage. 2012 Jan;20:430-439. <website>

Holt DW, Henderson ML, Stockdale CE, Farrell JT, Kooyman DL, Bridgewater LC, Seegmiller RE. Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: A new model of osteoarthritis. Osteoarthritis and Cartilage. 2012 Jan;20:430-439. <website>

Felin JE, Mayo JL, Loos TJ, Jensen JD, Sperry DK, Gaufin SL, Meinhart CA, Moss JB, Bridgewater LC. Nuclear variants of bone morphogenetic proteins. BMC Cell Biology. 2010 Jan;11:20. <website>

Mayo JL, Holden DN, Barrow JR, Bridgewater LC. The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation. Experimental Cell Research. 2009 May;315:2293-2300. <website>

Identification of a novel RARE that requires an enhancer element mediator for transcriptional activation. Biochemical Journal. 2004;383:37-43.

Abstract

Olsen DS, Bailey KT, Nichols BA, Bridgewater LC. Lack of nuclear BMP-2 causes reduced spleen size. FASEB J. 2013 Apr;27:601.12.

Nichols BA, Goar WA, McCune BT, Bridgewater LC. Nuclear localized BMP2 promotes cell cycle progression. FASEB J. 2013 Apr;27:1029.1.

Conference Proceedings

Cordner RD, Ventura JS, Blickenstaff JW, Walther CK, Mayo JL, Felin JE, Andreasen B, Wallace NB, Barrow JR, Edwards JG, et al. Mice bearing a targeted mutation of nBmp2 display decreased memory capabilities. 2010 Apr.

Seegmiller RE, Niederhauser CM, Monta?o C, Bomsta BD, Wink AE, Sudweeks SN. Aggrecan expression in Dmm mice. supplementth ed. Nashville, Tennessee: Matrix Biology; 2006 Nov.

Presentations

Bridgewater LC, Christensen L, Stolworthy DK, Fullwood RA, Merrell TM, Holland JG, Harmon LM, Robinson TF, Bowden AE. Development of an alpaca disc culture system for the study of intervertebral disc degeneration. Second International Spine Research Symposium. Philadelphia, PA. 2013 Nov.

Fullwood RA, Stolworthy DK, Bowden AE, Bridgewater LC. Alpaca cervical spine anatomy: Shape, size, AF/NP ratio. Emerging Ideas in Biomedical Research Conference. Provo, Utah. 2013 Oct.

Olsen DS, Bailey KT, Nichols BA, Bridgewater LC. Lack of nuclear BMP-2 causes reduced spleen size. American Society for Biochemistry and Molecular Biology. Boston, MA. 2013 Apr.

Rogers AC, Nichols BA, Loos TJ, Bridgewater LC. Nuclear Bmp4 interacts with the SCF E3 ubiquitin ligase complex and inhibits the cell cycle. American Society for Biochemistry and Molecular Biology Annual Meeting. San Diego, California. 2012 Apr.

Ricks M, Falk DJ, Farrell JT, Rees MB, Carr JM, Williams DT, Kooyman DL, Bridgewater LC, Seegmiller RE. Premature osteoarthritis in the temporomandibular joint of heterozygous disproportionate micromelia mice. American Society for Biochemistry and Molecular Biology Annual Meeting. San Diego, California. 2012 Apr.