Hansen, Marc

Physiology & Developmental Biology

597 WIDB
Provo, UT 84602
(801) 422-4998

Associate Professor

Research Interests

How do individual cancer cell detach from the primary tumor and colonize metastatic disease? We study cellular signaling that drives the decision to undergo metastasis, the mechanics of how cells physically detach their cell-cell interaction, and the cell biology of how cells select routes of invasion. Our goals are to reconstruct signaling networks that drive events of cancer metaastasis and to develop small molecule inhibitors that disrupt this network for use as future therapeutics. We combine traditional cell biology approaches with systems biology and chemical genetics.

Experience

Professional

Visiting Researcher, Imperial College London, 2012-2013

Memberships

American Association of Cancer Researchers, 2012-Present
American Society of Cell Biologists, 1998-Present

Courses Taught

Fall 2012

PDBIO 494R: Undergraduate Research Section 007
PDBIO 495R: Adv Undgraduate Research Section 006
PDBIO 649R: Laboratory Research Section 006
PDBIO 799R: Dissertation Section 004

Summer 2012

PDBIO 494R: Undergraduate Research Section 006
PDBIO 495R: Adv Undgraduate Research Section 006
PDBIO 649R: Laboratory Research Section 006

Spring 2012

PDBIO 494R: Undergraduate Research Section 006
PDBIO 495R: Adv Undgraduate Research Section 006
PDBIO 649R: Laboratory Research Section 006

Winter 2012

PDBIO 349R: PDBio Teaching Seminar Section 008
PDBIO 360: Cell Biology Section 001
PDBIO 494R: Undergraduate Research Section 006
PDBIO 495R: Adv Undgraduate Research Section 006
PDBIO 498: Advanced Senior Research Section 001
PDBIO 550R: Advanced Topics Section 010
PDBIO 649R: Laboratory Research Section 006
PDBIO 799R: Dissertation Section 002

Selected Publications

Journal Article

Barcellos K, Wagner M, Langford P, Call SG, Staley D, Chung J, Hansen MD. ARHGAP21: a new partner of α-tubulin involved in cell-cell adhesion formation and essential for Epithelial-Mesenchymal Transition. Journal of Biological Chemistry. 2012 Dec:epub.

Jake G, Moody J, Ascione M, Hansen MD. Zyxin-VASP interactions alter actin regulatory activity in zyxin-VASP complexes. Cellular and Molecular Biology Letters. 2012 Oct:epub.

Langford P, Keyes L, Hansen MD. Plasma membrane ion fluxes and NFAT-dependent gene transcription contribute to c-met-induced epithelial scattering. Journal of Cell Science. 2012;125:4001-4013.

Call SG, Brereton D, Bullard JT, Chung JY, Meacham KL, Morrell DJ, Reeder DJ, Schuler JT, Slade AD, Hansen MD. A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions. Biochemistry and Biophysics Research Communications. 2011 Nov;415:485-489.

Langford PR, Hansen MD. Initiation of epithelial-mesenchymal transition by c-met receptor tyrosine kinase signaling. Current Topics in Biochemical Research. 2011 Oct;13:81-90.

Chung JY, Davis JA, Price B, Staley DM, Wagner MV, Warner SL, Bearss DJ, Hansen MD. Competitive enhancement of HGF-induced epithelial scattering by accessory growth factors. Experimnetal Cell Research. 2011 Feb;317:307-318.

Call SG, Chung JY, Davis JA, Proce BD, Primavera TS, Thomson NC, Wagner MV, Hansen MD. Zyxin phosphorylation at serine 142 modulates the zyxin head-tail interaction to alter cell-cell adhesion. Biochemistry and Biophysics Research Communications. 2011 Jan;404:780-784.

Sperry R, Bishop N, Bramwell J, Carter M, Fowler B, Maxfield S, Lewis Z, Staley D, Vellinga R, Brodeur M, et al. Actin-membrane linkages at adherens junctions of cell undergoing epithelial-mesenchyme transition. Journal of Cellular Physiology. 2010 Mar;222:612-624.