The College of Life Sciences

Hansen, Marc

Physiology & Developmental Biology

Email: marchansen@byu.edu

597  WIDB
Provo, UT 84602
(801) 422-4998

Associate Professor
 Research Interests
How do individual cancer cell detach from the primary tumor and colonize metastatic disease? We study cellular signaling that drives the decision to undergo metastasis, the mechanics of how cells physically detach their cell-cell interaction, and the cell biology of how cells select routes of invasion. Our goals are to reconstruct signaling networks that drive events of cancer metaastasis and to develop small molecule inhibitors that disrupt this network for use as future therapeutics. We combine traditional cell biology approaches with systems biology and chemical genetics.
 Education
  • PhD, Cancer Biology, Stanford, 2002
  • B.S., Molecular Biology, Brigham Young University, 1997
 Experience

Professional
  • Post-Doctoral Fellow, Huntsman Cancer Institute, 2002-2005
 Courses Taught

Fall 2011
  • PDBIO 360: Cell Biology Section 002
  • PDBIO 494R: Undergraduate Research Section 006
  • PDBIO 495R: Adv Undgraduate Research Section 005
  • PDBIO 550R: Advanced Topics Section 006
  • PDBIO 649R: Laboratory Research Section 005
  • PDBIO 799R: Dissertation Section 003
Summer 2011
  • PDBIO 494R: Undergraduate Research Section 005
  • PDBIO 799R: Dissertation Section 002
Spring 2011
  • PDBIO 494R: Undergraduate Research Section 005
  • PDBIO 495R: Adv Undgraduate Research Section 005
  • PDBIO 799R: Dissertation Section 002
Winter 2011
  • LFSCI 494R: Mentored Research Section 002
  • PDBIO 349R: PDBio Teaching Seminar Section 006
  • PDBIO 360: Cell Biology Section 001, 002
  • PDBIO 494R: Undergraduate Research Section 005
  • PDBIO 495R: Adv Undgraduate Research Section 005
  • PDBIO 550R: Advanced Topics Section 011
  • PDBIO 799R: Dissertation Section 001

Selected Publications
Journal Article

Langford, P. R., Hansen, M.  "Initiation of epithelial-mesenchymal transition by c-met receptor tyrosine kinase signaling."  Current Topics in Biochemical Research.  Vol. 13 (2011): 81-90. 

Call, S. G., Brereton, D., Bullard, J. T., Chung, J. Y., Meacham, K. L., Morrell, D. J., Reeder, D. J., Schuler, J. T., Slade, A. D., Hansen, M.  "A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions."  Biochemistry and Biophysics Research Communications.  Vol. 415 (2011): 485-489. 

Call, S. G., Chung, J. Y., Davis, J. A., Proce, B. D., Primavera, T. S., Thomson, N. C., Wagner, M. V., Hansen, M.  "Zyxin phosphorylation at serine 142 modulates the zyxin head-tail interaction to alter cell-cell adhesion.."  Biochemistry and Biophysics Research Communications.  Vol. 404 (2011): 780-784. 

Chung, J. Y., Davis, J. A., Price, B., Staley, D. M., Wagner, M. V., Warner, S. L., Bearss, D. J., Hansen, M.  "Competitive enhancement of HGF-induced epithelial scattering by accessory growth factors."  Experimnetal Cell Research.  Vol. 317 (2011): 307-318. 

Sperry, R., Bishop, N., Bramwell, J., Carter, M., Fowler, B., Maxfield, S., Lewis, Z., Staley, D., Vellinga, R., Brodeur, M., Hansen, M.  "Actin-membrane linkages at adherens junctions of cell undergoing epithelial-mesenchyme transition."  Journal of Cellular Physiology.  Vol. 222 (2010): 612-624.