Bikman, Benjamin

Physiology & Developmental Biology

Email: 2dgplcokpadkmocpBd{w0gfw  (Email Form)

3017  LSB
Provo, UT 84602
(801) 422-1798

Associate Professor

Curriculum Vitae

 Research Interests
Current worldwide trends highlight the critical role of obesity in a myriad of debilitating and deadly diseases, including diabetes, cardiovascular disease, and some cancers. The prevalence of these diseases and others is expected to increase as the number of obese individuals continues to climb worldwide.

The focus of my lab (the Laboratory of Obesity and Metabolism) is twofold. First, we aim to identify the molecular mechanisms that explain the increased risk of disease that accompanies weight gain, with particular emphasis on the etiology of insulin resistance and disrupted mitochondrial function. Second, we hope to reveal novel cellular processes that are responsible for fat development.

Much of our recent work is focused on the pathogenicity of the hormone insulin. Insulin, while necessary for life, elicits significant and harmful changes in tissue metabolic function when chronically elevated. Several projects have stemmed from this work, including a focus on the contrasting effects of dietary macronutrients (e.g. carbohydrates vs. fats) on insulin homeostasis, the effects of insulin on brown adipose tissue (and metabolic rate), and insulin-induced heart failure.

We employ numerous pharmacological and genetic tools to better understand the origins and consequences of ceramide accumulation on various factors related to metabolic function, including signal transduction, substrate utilization, and energy expenditure.
 Education
  • Doctor of Philosophy, Bioenergetics, East Carolina University, 2008
  • Master of Science, Exercise Physiology, Brigham Young University, 2005
  • Bachelor of Science, Exercise Science, Brigham Young University, 2003
 Experience

Academic - Post-Secondary
  • Postdoctoral Research Fellow, Duke-National University of Singapore Medical School, 2009-2011

 Memberships
  • Mitochondrial Physiology Society, 2012-Present
  • The Obesity Society, 2012-Present
  • American Diabetes Association, 2011-Present
  • American Physiological Society, 2010-Present
 Honors and Awards
  • Oroboros Instruments : Travel Award
  • Keystone Symposium : Travel Scholarship
  • NIH: Pre-doctoral fellowship
 Courses Taught

Summer 2017
  • PDBIO 494R: Undergraduate Research Section 004
  • PDBIO 495R: Adv Undgraduate Research Section 004
Spring 2017
  • PDBIO 494R: Undergraduate Research Section 004
  • PDBIO 495R: Adv Undgraduate Research Section 004
  • PDBIO 699R: Master's Thesis Section 004
Winter 2017
  • PDBIO 365: Pathophysiology Section 001
  • PDBIO 494R: Undergraduate Research Section 004
  • PDBIO 495R: Adv Undgraduate Research Section 004
  • PDBIO 649R: Laboratory Research Section 004
  • PDBIO 699R: Master's Thesis Section 004
Fall 2016
  • PDBIO 365: Pathophysiology Section 002
  • PDBIO 494R: Undergraduate Research Section 004
  • PDBIO 495R: Adv Undgraduate Research Section 004
  • PDBIO 601: Cell & Molecular Physiology Section 001
  • PDBIO 649R: Laboratory Research Section 004
  • PDBIO 699R: Master's Thesis Section 004

Selected Publications

Journal Articles

Taylor OJ, Thatcher MO, Carr ST, Gibbs JL, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, et al. 2017. High-Mobility Group Box 1 Disrupts Metabolic Function with Cigarette Smoke Exposure in a Ceramide-Dependent Manner. 18(5).  doi:10.3390/ijms18051099

Napa K, Baeder AC, Witt JE, Rayburn ST, Miller MG, Dallon BW, Gibbs JL, Wilcox SH, Winden DR, Smith JH, et al. 2017. LPS from P. gingivalis Negatively Alters Gingival Cell Mitochondrial Bioenergetics. 2017(2697210).  doi:10.1155/2017/2697210

Sanders NT, Dutson DJ, Durrant JW, Lewis JB, Wilcox SH, Winden DR, Arroyo JA, Bikman BT, Reynolds PR. 2017. Cigarette smoke extract (CSE) induces RAGE-mediated inflammation in the Ca9-22 gingival carcinoma epithelial cell line. 80:95-100.  doi:10.1016/j.archoralbio.2017.03.021

Lewis JB, Hirschi KM, Arroyo JA, Bikman BT, Kooyman DL, Reynolds PR. 2017. Plausible Roles for RAGE in Conditions Exacerbated by Direct and Indirect (Secondhand) Smoke Exposure. Int J Mol Sci. 18(3):E652.  doi:10.3390/ijms18030652

Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS. 2016. β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. 311(1):E186-201.  doi:10.1152/ajpendo.00022.2016

Baeder AC, Napa K, Richardson ST, Taylor OJ, Andersen SG, Wilcox SH, Winden DR, Reynolds PR, Bikman BT. 2016. Oral Gingival Cell Cigarette Smoke Exposure Induces Muscle Cell Metabolic Disruption. 2016:2763160.  doi:10.1155/2016/2763160

Hodson AE, Tippetts TS, Bikman BT. 2015. Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function. 14(1):153.  doi:10.1186/s12933-015-0316-y

Hansen ME, Simmons KJ, Tippetts TS, Thatcher MO, Saito RR, Hubbard ST, Trumbull AM, Parker BA, Taylor OJ, Bikman BT. 2015. Lipopolysaccharide Disrupts Mitochondrial Physiology in Skeletal Muscle via Disparate Effects on Sphingolipid Metabolism. Shock.  doi:10.1097/SHK.0000000000000468

Kwon OS, Tanner RE, Barrows KM, Runtsch M, Symons JD, Jalili T, Bikman BT, McClain DA, O'Connell RM, Drummond MJ. 2015. MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance. American Journal of Physiology - Endocrinology and Metabolism. 309(1):E11-21.  doi:10.1152/ajpendo.00124.2015

Nelson MB, Swensen AC, Winden DR, Bodine JS, Bikman BT, Reynolds PR. 2015. Cardiomyocyte mitochondrial respiration is reduced by receptor for advanced glycation end-product signaling in a ceramide-dependent manner. American Journal of Physiology - Heart Circ Physiol. 309:H63-H69.

Gibby J, Njeru D, Cvetko S, Merrill RM, Bikman BT, Gibby W. 2015. Volumetric analysis of central body fat accurately predicts incidence of diabetes and hypertension in adults. BMC Obesity. 2(1):10.

Tippetts TS, Winden DR, Swensen AC, Nelson MB, Thatcher MO, Saito RR, Condie TB, Simmons KJ, Judd AM, Reynolds PR, et al. 2014. Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration. BMC Cardiovascular Disorders. 14(1):165.

Thatcher MO, Tippetts TS, Nelson MB, Swensen AC, Winden DR, Hansen ME, Anderson MC, Johnson IE, Porter JP, Reynolds PR, et al. 2014. Ceramides mediate cigarette smoke-induced metabolic disruption in mice. American Journal of Physiology - Endocrinology and Metabolism. 307:E919-E927.

DeMille D, Bikman BT, Mathis AD, Prince JT, Mackay JT, Sowa SW, Hall TD, Grose JH. 2014. A comprehensive protein-protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1. Molecular Biology of the Cell. 25(14):2199-2215.

Hansen ME, Tippetts TS, Moulton ER, Holub ZE, Swensen AC, Prince JT, Bikman BT. 2014. Insulin Increases Ceramide Synthesis in Skeletal Muscle. Journal of Diabetes Research. 14(Article ID 765784):9. <website>

Smith M, Tippetts T, Brassfield E, Tucker B, Ockey A, Swensen A, Anthonymuthu T, Washburn T, Kane D, Prince JT, et al. 2013. Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle. Biochemical Journal. 456(3):427-39.  doi:10.1042/BJ20130807

Erickson KA, Smith ME, Anthonymuthu TS, Brassfield ES, Tucker BJ, Prince JT, Hancock CR, Bikman BT. 2012. AICAR inhibits ceramide biosynthesis in skeletal muscle. Diabetology and Metabolic Syndrome. 4(45):1-7. <website>

Siddique MM, Bikman BT, Wang L, Wenk MW, Summers SA. 2012. Ablation of dihydroceramide desaturase confers resistance to Etoposide-induced apoptosis in vitro. PLoS One. 7(9):e44042.

Bikman BT, Guan Y, Shui G, Mobin M S, Kim J, Wenk MR, Summers SA. 2012. Fenretinide prevents prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. Journal of Biological Chemistry. 287:17426-17437.

Bikman BT. 2012. A Role for Sphingolipids in the Pathophysiology of Obesity-induced Inflammation. Cell Mol Life Sci. DOI 10.1007/s00018-012-0917-5.

Bikman BT, Summers SA. 2011. Ceramides as Modulators of Cellular and Whole-body Metabolism. Journal of Clinical Investigation. 121(11):4222-4230.

Holland WL, Bikman BT, Summers SA. 2011. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice. Journal of Clinical Investigation. 121(5):1858-1870. <website>

Bikman BT, Summers SA. 2011. Sphingolipids and Hepatic Steatosis. Adv Exp Med Biol. 721:89-97.

Bikman BT, Dohm GL, Houmard JA. 2010. Lipid-induced insulin resistance is prevented in lean and obese myotubes with AICAR treatment. Am J Physiol Regulatory Integrative Comp Physiol. 298:R1692-R1699.

Bikman BT, Dohm GL. 2010. Metformin Improves Skeletal Muscle Insulin Signaling in Obese Rats in a Fiber-type Dependent Manner. Journal of Obesity. doi:10.1155/2010/970865.

Kane DA, Bikman BT, Neufer PD. 2010. Metformin Selectively Attenuates Mitochondrial H2O2 Emission without Affecting Respiratory Capacity in Skeletal Muscle of Obese Rats. Free Radical Biology and Medicine. 49(6):1082-1087.

Holland WL, Bikman BT, Summers SA, Scherer PE. 2010. The Pleiotropic Actions of Adiponectin are Initiated via Receptor-Mediated Activation of Neutral Ceramidase Activity. Nature Medicine. 17(1):55-63.

Bikman BT, Cortright RN. 2009. The effects of intrinsic aerobic capacity and diet on insulin signaling and IKKβ activity in rats. International Journal of Sports Medicine. 30:631-635.

Bikman BT, Dohm GL. 2008. Mechanism(s) for Improved Insulin Sensitivity After Gastric Bypass Surgery. Journal of Endocrinology and Metabolism. 93:4656-4663.

Stob N, Bikman BT, Bell C. 2007. Increased Thermogenic Responsiveness to Intravenous Beta-Adrenergic Stimulation in Habitual Exercisers is Not Related to Skeletal Muscle Beta2-Adrengergic Receptor Density. Experimental Physiology. 92:8230830.

Book Chapter

Bikman BT, Summers SA. 2010. Sphingolipids and Hepatic Steatosis. , editor. Sphingolipids and Metabolic Diseases.

Magazine Article

Bikman BT, Bressler MA. 2011. Inflammation and Metabolic Syndrome.

Presentations

Bikman BT. Ceramides as mediators of metabolic disruption. ACSM. Boston. 2016 .

Hodson A, Tippetts T, Bikman BT. Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function. Experimental Biology. San Diego. 2016 .

Grose JH, Bikman BT, Demille D, Pattison J. The role of PAS kinase in controlling cellular respiration. Analytical Genetics. Rotorua, New Zealand. 2016 .

Grose JH, Bikman BT, DeMille D. The role of PAS kinase in controlling cellular respiration. Multifaceted Mitochondria. Chicago, Illinois. 2015 .

Bikman BT. Ceramides are Necessary for Cigarette Smoke-induced Metabolic Disruption. Experimental Biology. 2015 .

Simmons K, Hansen M, Thatcher M, Tippetts T, Bikman BT. Ceramides Mediates Metabolic Disruption with LPS Treatment in Skeletal Muscle. Experimental Biology. 2015 .

Saito R, Simmons K, Hansen M, Thatcher M, Bikman BT. LPS-induced Heart Disruption Requires Ceramides. Experimental Biology. 2015 .

Grose JH, Pattinson J, DeMille D, Bikman BT. The transcription factor centromere binding factor 1 (Cbf1) as a central point of control to upregulate mitochondrial activity and decrease lipid biogenesis in the yeast Saccharomyces cerevisiae”. Tri-Branch ASM Meeting. Durgano, Colorado. 2015 .

Bikman BT. Mitochondrial Fission is Necessary for Ceramide-induced Metabolic Disruption. American Diabetes Association. San Francisco. 2014 .

Bikman BT. Regulators of Muscle Metabolic Function. Utah Vascular Research Laboratory Colloquium Series. Salt Lake City UT. 2013 .

Bikman BT. Mitochondrial Fission as a Mediator of Ceramide-induced Metabolic Disruption. Southwest ACSM. Newport Beach CA. 2013 .

Bikman BT, Tucker BJ. Ceramide Increases ROS Generation via Mitochondrial Fission. EB. 2013 .

Bikman BT, Thatcher MO. Ceramide Mediates Cigarette Smoke-induced Insulin Resistance. EB. 2013 .

Bikman BT, Smith ME. Mitochondrial Fission as a Mediator of Ceramide-induced Metabolic Disruption. EB. Boston. 2013 .

Bikman BT. Ceramides and Mitochondrial Function. O2K - High Resolution Respirometry. Schroecken, Austria. 2012 .

Bikman BT, Erickson KA, Smith ME. AICAR inhibits ceramide biosynthesis in skeletal muscle. Integrative Biology of Exercise. Westminster, CO. 2012 .

Bikman BT. Dihydroceramide desaturase inhibition prevents ceramide accumulation and improves insulin sensitivity. FASEB Summer Conference - Glucose Transporters, Signaling, and Diabetes. Keystone Colorado. 2011 .

Bikman BT. Fenretinide improves insulin sensitivity by inhibiting dihydroceramide desaturase and preventing ceramide accumulation. Lipid Biology and Lipotoxicity. Killarney Ireland. 2011 .

Bikman BT. Fenretinide improves insulin sensitivity by inhibiting dihydroceramide desaturase and preventing ceramide accumulation. Type 2 Diabetes, insulin resistance, and metabolic function. Keystone Colorado. 2011 .

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