Biography
I grew up playing in the mountains of Utah County and later attended BYU in the Microbiology and Molecular Biology Department. I continued my education at Louisiana State University Health Sciences Center in Shreveport, Louisiana where I studied cell biology, molecular biology and host-pathogen interactions. I moved to Seattle with my young family and continued to focus on host-pathogen interactions while my wife pursued a Ph.D. in Geology. Later, my wife and I both found positions teaching at BYU. I have greatly enjoyed working with BYU students in a teaching laboratory setting where I get to share my love of molecular biology through hands on interactions with students in MMBIO 241. When I’m not teaching, my family and I participate together in many outdoor activities from skiing to flyfishing, camping and hiking.
Teaching Interests
Molecular Biology and Cellular Biology Laboratory, Immunology
Education
Louisiana State University Health Sciences Center, Postdoctoral Fellow (2005 – 2007)
Institute for Systems Biology, Postdoctoral Fellow (2001 – 2005)
Louisiana State University Health Sciences Center, Ph.D. (2001)
Brigham Young University, Molecular Biology, B.Sc. (1995)
Honors and Awards
Irvington Institute for Immunological Research Fellow, Class of 2005
The Dean’s Award for Excellence in Graduate Studies, 2001
Publications
Rupper, A. and Cardelli J. Large-Scale Purification of Latex Bead Phagosomes from Mouse Macrophage Cell Lines and Subsequent Preparation for High-Throughput Quantitative Proteomics.Methods in Molecular Biology, Phagosome and Autophagosome. 2008. 445:339-351.
Rupper A., Cardelli J. Induction of Guanylate Binding Protein 5 by Gamma Interferon Increases Susceptibility to Salmonella enterica Serovar Typhimurium-Induced Pyroptosis in RAW 264.7 Cells. 2008. Infect. Immun. 76:2304-2315.
Rupper, A., and J. Cardelli. 2001. Regulation of phagocytosis and endo-phagosomal trafficking pathways in Dictyostelium discoideum. Biochim Biophys Acta. 1525:205-16.
Rupper, A., B. Grove, and J. Cardelli. 2001a. Rab7 regulates phagosome maturation in Dictyostelium. J Cell Sci. 114:2449-60.
Rupper, A., K. Lee, D. Knecht, and J. Cardelli. 2001b. Sequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in Dictyostelium. Mol Biol Cell. 12:2813-24.
Comment in: Trends Cell Biol. 2002 Jan;12(1):11.
Rupper, A.C., J.M. Rodriguez-Paris, B.D. Grove, and J.A. Cardelli. 2001c. p110-related PI 3-kinases regulate phagosome-phagosome fusion and phagosomal pH through a PKB/Akt dependent pathway in Dictyostelium. J Cell Sci. 114:1283-95.
Solomon, J.M., A. Rupper, J.A. Cardelli, and R.R. Isberg. 2000. Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions. Infect Immun. 68:2939-47.