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College of Life Sciences
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Marc Hansen

Professor
Physiology & Developmental Biology
Website: pdbio.byu.edu/Research/Dr-M-Hansen
Contact

3067 LSB
Provo, UT 84602

801-422-4998

Biography

Biography


I am from Vancouver Island (Victoria) in BC, Canada, attended BYU from 1991 to 1997 with a mission in Marseille, France during that time. After a BS in Molecular Biology from BYU, I earned a PhD in Cancer Research from Stanford and completed a post-doc at Huntsman Cancer Institute.

Teaching Interests


I teach introductory biology for majors (PDBIO120) and have taught Cell Biology (PDBIO360) and Histology (PDBIO325) in the past. Outside of molecular and cell biology, I am interested in teaching BIO-innovation courses. These courses address how technologies and ideas rooted in the life sciences become new companies that create prosperity and jobs.

Research Interests


I came to BYU seeking to understand how individual epithelial cells detach from tissues, a process called epithelial-mesenchymal transition that occurs throughout development and that is recapitulated in cancer metastasis. After over 10 years of dissecting this process, serendipity led us to discover a novel small molecule drug that may soon enter clinical trials. Having developed a passion for drug discovery, we now work to develop new small molecule therapeutics for human diseases that have poor current treatment options.

Experience

Professional

  • Visiting Researcher, Imperial College London, 2012-2013

Memberships

American Association of Cancer Researchers, 2012-Present

  • American Society of Cell Biologists, 1998-Present

Courses Taught
Winter 2019

  • PDBIO 295R: Introductory Undgrad Research Section 007
  • PDBIO 349R: PDBio Teaching Experience Section 009
  • PDBIO 445: Bio-Innovation 2 Section 001
  • PDBIO 455R: PDBio Seminar Section 001
  • PDBIO 495R: Adv Undergraduate Research Section 007, 020
  • PDBIO 649R: Laboratory Research Section 007
  • PDBIO 699R: Master's Thesis Section 007

Fall 2018

  • PDBIO 120: Science of Biology Section 003
  • PDBIO 295R: Introductory Undgrad Research Section 007
  • PDBIO 349R: PDBio Teaching Experience Section 008
  • PDBIO 444: Bio-Innovation 1 Section 001
  • PDBIO 455R: PDBio Seminar Section 001
  • PDBIO 495R: Adv Undergraduate Research Section 007, 020
  • PDBIO 498: Advanced Senior Research Section 001
  • PDBIO 699R: Master's Thesis Section 007

Summer 2018

  • PDBIO 295R: Introductory Undgrad Research Section 007
  • PDBIO 495R: Adv Undgraduate Research Section 007

Spring 2018

  • PDBIO 295R: Introductory Undgrad Research Section 007
  • PDBIO 495R: Adv Undgraduate Research Section 007
  • PDBIO 550R: Advanced Topics in PDBio Section 007

Research Interests

I came to BYU seeking to understand how individual epithelial cells detach from tissues, a process called epithelial-mesenchymal transition that occurs throughout development and that is recapitulaled in cancer metastasis. After over 10 years of dissecting this process, serendipity led us to discover a novel small molecule drug that may soon enter clinical trials. Having developed a passion for drug discovery, we now work to develop new small molecule therapeutics for human diseases that have poor current treatment options.

Teaching Interests

I teach introductory biology for majors (PDBIO120) and have taught Cell Biology (PDBIO360) and Histology (PDBIO325) in the past. I also teach BIO-innovation courses (PDBIO 444 and 445), which address how technologies and ideas rooted in the life sciences become new companies that create prosperity and jobs.

Memberships

  • American Association of Cancer Researchers: ( - Present)
  • American Society of Cell Biologists: ( - Present)

Courses Taught

2020

  • PDBIO 495R: Section 007
  • PDBIO 495R: Section 007
  • PDBIO 495R: Section 007
  • PDBIO 495R: Section 021
  • PDBIO 445 : Section 001
  • PDBIO 295R: Section 007
  • PDBIO 455R: Section 001

2019

  • PDBIO 495R: Section 007
  • PDBIO 498 : Section 002
  • PDBIO 444 : Section 001
  • PDBIO 295R: Section 007
  • PDBIO 455R: Section 001
  • PDBIO 349R: Section 008
  • PDBIO 120 : Section 003
  • PDBIO 495R: Section 007
  • PDBIO 498 : Section 001
  • PDBIO 699R: Section 007
  • PDBIO 495R: Section 007
  • PDBIO 295R: Section 007
  • PDBIO 699R: Section 007
  • PDBIO 495R: Section 007
  • PDBIO 495R: Section 020
  • PDBIO 445 : Section 001
  • PDBIO 295R: Section 007
  • PDBIO 649R: Section 007
  • PDBIO 699R: Section 007
  • PDBIO 455R: Section 001
  • PDBIO 349R: Section 009

2018

  • PDBIO 495R: Section 007
  • PDBIO 495R: Section 020
  • PDBIO 498 : Section 001
  • PDBIO 444 : Section 001
  • PDBIO 295R: Section 007
  • PDBIO 699R: Section 007
  • PDBIO 455R: Section 001
  • PDBIO 349R: Section 008
  • PDBIO 120 : Section 003
  • PDBIO 495R: Section 007
  • PDBIO 295R: Section 007
  • PDBIO 495R: Section 007
  • PDBIO 550R: Section 007
  • PDBIO 295R: Section 007
  • PDBIO 495R: Section 007
  • PDBIO 495R: Section 012
  • PDBIO 550R: Section 010
  • PDBIO 445 : Section 001
  • PDBIO 360 : Section 002
  • PDBIO 295R: Section 007
  • PDBIO 649R: Section 007
  • PDBIO 455R: Section 001
  • PDBIO 349R: Section 009

2017

  • PDBIO 495R: Section 008
  • PDBIO 495R: Section 010
  • PDBIO 498: Section 1
  • PDBIO 444 : Section 001
  • PDBIO 295R: Section 008
  • PDBIO 649R: Section 008
  • PDBIO 455R: Section 001
  • PDBIO 349R: Section 008
  • PDBIO 120 : Section 004
  • PDBIO 120 : Section 005
  • PDBIO 495R: Section 008
  • PDBIO 550R: Section 011
  • PDBIO 799R: Section 8
  • BUS M 478A: Section 001
  • PDBIO 455R: Section 001
  • PDBIO 494R: Section 8

2016

  • PDBIO 495R: Section 008
  • PDBIO 550R: Section 009
  • PDBIO 799R: Section 7
  • PDBIO 455R: Section 001
  • PDBIO 349R: Section 008
  • PDBIO 120 : Section 004
  • PDBIO 120 : Section 005
  • PDBIO 494R: Section 008
  • PDBIO 495R: Section 008
  • PDBIO 799R: Section 4
  • PDBIO 494R: Section 008
  • PDBIO 495R: Section 008
  • PDBIO 799R: Section 5
  • PDBIO 494R: Section 008
  • PDBIO 495R: Section 008
  • PDBIO 550R: Section 011
  • PDBIO 550R: Section 10
  • PDBIO 799R: Section 8
  • PDBIO 699R: Section 8
  • PDBIO 455R: Section 001
  • PDBIO 349R: Section 10
  • PDBIO 494R: Section 008

2015

  • PDBIO 495R: Section 009
  • PDBIO 498: Section 1
  • PDBIO 550R: Section 010
  • PDBIO 799R: Section 7
  • PDBIO 649R: Section 009
  • PDBIO 699R: Section 009
  • PDBIO 455R: Section 001
  • PDBIO 349R: Section 8
  • PDBIO 120 : Section 005
  • PDBIO 120 : Section 006
  • PDBIO 494R: Section 010
  • PDBIO 495R: Section 030
  • PDBIO 799R: Section 014
  • PDBIO 699R: Section 027
  • PDBIO 494R: Section 030
  • PDBIO 495R: Section 009
  • PDBIO 799R: Section 005
  • PDBIO 699R: Section 009
  • PDBIO 494R: Section 009
  • PDBIO 495R: Section 009
  • PDBIO 550R: Section 011
  • PDBIO 550R: Section 012
  • PDBIO 360 : Section 001
  • PDBIO 799R: Section 009
  • PDBIO 699R: Section 009
  • PDBIO 455R: Section 001
  • PDBIO 494R: Section 009

2014

  • PDBIO 495R: Section 008
  • PDBIO 550R: Section 009
  • PDBIO 799R: Section 007
  • PDBIO 649R: Section 008
  • PDBIO 699R: Section 008
  • PDBIO 455R: Section 001
  • PDBIO 120 : Section 006
  • PDBIO 494R: Section 009
  • PDBIO 495R: Section 029
  • PDBIO 799R: Section 013
  • PDBIO 649R: Section 027
  • PDBIO 699R: Section 024
  • PDBIO 494R: Section 029
  • PDBIO 495R: Section 008
  • PDBIO 799R: Section 003
  • PDBIO 649R: Section 008
  • PDBIO 699R: Section 007
  • PDBIO 494R: Section 008
  • PDBIO 495R: Section 008
  • PDBIO 799R: Section 004
  • PDBIO 699R: Section 008
  • PDBIO 455R: Section 001
  • PDBIO 494R: Section 008

2013

  • PDBIO 495R: Section 008
  • PDBIO 799R: Section 006
  • PDBIO 649R: Section 008
  • PDBIO 661 : Section 001
  • PDBIO 455R: Section 001
  • PDBIO 120 : Section 003
  • PDBIO 120 : Section 005
  • PDBIO 120 : Section 007
  • PDBIO 494R: Section 009
  • PDBIO 495R: Section 008
  • PDBIO 649R: Section 008
  • PDBIO 495R: Section 008
  • PDBIO 649R: Section 008
  • PDBIO 495R: Section 008
  • PDBIO 799R: Section 004
  • PDBIO 649R: Section 008
  • PDBIO 494R: Section 008

2012

  • PDBIO 495R: Section 006
  • PDBIO 799R: Section 004
  • PDBIO 649R: Section 006
  • PDBIO 494R: Section 007
  • PDBIO 495R: Section 006
  • PDBIO 649R: Section 006
  • PDBIO 494R: Section 006
  • PDBIO 495R: Section 006
  • PDBIO 649R: Section 006
  • PDBIO 494R: Section 006
  • PDBIO 495R: Section 006
  • PDBIO 498 : Section 001
  • PDBIO 550R: Section 010
  • PDBIO 360 : Section 001
  • PDBIO 799R: Section 002
  • PDBIO 649R: Section 006
  • PDBIO 349R: Section 008
  • PDBIO 494R: Section 006

2011

  • PDBIO 495R: Section 005
  • PDBIO 550R: Section 006
  • PDBIO 360 : Section 002
  • PDBIO 799R: Section 003
  • PDBIO 649R: Section 005
  • PDBIO 494R: Section 006
  • PDBIO 799R: Section 002
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 799R: Section 002
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 550R: Section 011
  • PDBIO 360 : Section 001
  • PDBIO 360 : Section 002
  • PDBIO 799R: Section 001
  • LFSCI 494R: Section 002
  • PDBIO 349R: Section 006
  • PDBIO 494R: Section 005

2010

  • PDBIO 495R: Section 005
  • PDBIO 498 : Section 001
  • PDBIO 360 : Section 002
  • PDBIO 799R: Section 002
  • LFSCI 494R: Section 010
  • PDBIO 661 : Section 001
  • PDBIO 494R: Section 006
  • PDBIO 495R: Section 005
  • PDBIO 799R: Section 002
  • LFSCI 494R: Section 007
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 799R: Section 002
  • LFSCI 494R: Section 011
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 550R: Section 011
  • PDBIO 360 : Section 001
  • PDBIO 360 : Section 002
  • PDBIO 799R: Section 001
  • PDBIO 649R: Section 005
  • LFSCI 494R: Section 014
  • PDBIO 349R: Section 005
  • PDBIO 494R: Section 005

2009

  • PDBIO 495R: Section 005
  • PDBIO 360 : Section 001
  • PDBIO 360 : Section 002
  • LFSCI 494R: Section 008
  • PDBIO 349R: Section 006
  • PDBIO 494R: Section 006
  • PDBIO 495R: Section 005
  • PDBIO 360 : Section 001
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 799R: Section 002
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 799R: Section 001
  • LFSCI 494R: Section 024
  • PDBIO 494R: Section 005

2008

  • PDBIO 495R: Section 005
  • PDBIO 360 : Section 001
  • PDBIO 360 : Section 002
  • PDBIO 649R: Section 004
  • LFSCI 494R: Section 037
  • PDBIO 349R: Section 006
  • PDBIO 650R: Section 001
  • PDBIO 494R: Section 006
  • PDBIO 495R: Section 005
  • BIOL 494R: Section 017
  • PDBIO 495R: Section 005
  • BIOL 494R: Section 016
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • BIOL 360 : Section 001
  • BIOL 360 : Section 002
  • PDBIO 799R: Section 001
  • BIOL 494R: Section 029
  • PDBIO 650R: Section 002
  • PDBIO 494R: Section 005

2007

  • PDBIO 495R: Section 005
  • PDBIO 799R: Section 002
  • BIOL 494R: Section 019
  • PDBIO 349R: Section 001
  • PDBIO 650R: Section 001
  • PDBIO 325 : Section 002
  • PDBIO 325 : Section 003
  • PDBIO 325 : Section 004
  • PDBIO 325 : Section 005
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 649R: Section 004
  • BIOL 120 : Section 001
  • PDBIO 650R: Section 003
  • PDBIO 494R: Section 005
  • PDBIO 495R: Section 005
  • PDBIO 550R: Section 005
  • PDBIO 799R: Section 001
  • PDBIO 649R: Section 004
  • BIOL 494R: Section 006
  • PDBIO 349R: Section 004
  • PDBIO 225 : Section 001
  • PDBIO 225 : Section 002
  • PDBIO 225 : Section 003
  • PDBIO 225 : Section 004
  • PDBIO 225 : Section 005
  • PDBIO 225 : Section 006
  • PDBIO 494R: Section 005

2006

  • PDBIO 495R: Section 004
  • PDBIO 649R: Section 010
  • BIOL 494R: Section 011
  • PDBIO 225 : Section 001
  • PDBIO 225 : Section 002
  • PDBIO 225 : Section 003
  • PDBIO 225 : Section 004
  • PDBIO 225 : Section 005
  • PDBIO 494R: Section 004
  • PDBIO 649R: Section 005
  • PDBIO 649R: Section 007
  • BIOL 120 : Section 001
  • PDBIO 494R: Section 004
  • PDBIO 495R: Section 005
  • PDBIO 649R: Section 007
  • BIOL 494R: Section 028
  • BIOL 120 : Section 005
  • PDBIO 225 : Section 002
  • PDBIO 225 : Section 003
  • PDBIO 225 : Section 004
  • PDBIO 225 : Section 005
  • PDBIO 225 : Section 006
  • PDBIO 494R: Section 005

2005

  • BIOL 494R: Section 028
  • PDBIO 225 : Section 001
  • PDBIO 225 : Section 003
  • PDBIO 225 : Section 004
  • PDBIO 225 : Section 005
  • PDBIO 494R: Section 015

Publications

  • Hansen MD, Hoj J, Davis J, Fullmer K, Morrell D, Saguibo N. April (2nd Quarter/Spring), 2014. Cellular Contractility Changes are Sufficient to Drive Cellular Scattering.
  • Barcellos K, Bigarella, Wagner M, Vieira, Lazarini, Langford P, Machado-Neto, Call SG, Staley D, Chung J, et alJanuary (1st Quarter/Winter), 2013. ARHGAP21: a new partner of α-tubulin involved in cell-cell adhesion formation and essential for Epithelial-Mesenchymal Transition.
  • Jake G, Moody J, Ascione M, Hansen MD. January (1st Quarter/Winter), 2013. Zyxin-VASP interactions alter actin regulatory activity in zyxin-VASP complexes.
  • Hansen MD. January (1st Quarter/Winter), 2013. Control of actin dynamics by allosteric regulation of actin binding proteins.
  • Langford P, Keyes L, Hansen MD. 2012. Plasma membrane ion fluxes and NFAT-dependent gene transcription contribute to c-met-induced epithelial scattering.
  • Call SG, Brereton D, Bullard JT, Chung JY, Meacham KL, Morrell DJ, Reeder DJ, Schuler JT, Slade AD, Hansen MD. November, 2011. A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions.
  • Langford PR, Hansen MD. October (4th Quarter/Autumn), 2011. Initiation of epithelial-mesenchymal transition by c-met receptor tyrosine kinase signaling.
  • Chung JY, Davis JA, Price B, Staley DM, Wagner MV, Warner SL, Bearss DJ, Hansen MD. February, 2011. Competitive enhancement of HGF-induced epithelial scattering by accessory growth factors.
  • Call SG, Chung JY, Davis JA, Proce BD, Primavera TS, Thomson NC, Wagner MV, Hansen MD. January (1st Quarter/Winter), 2011. Zyxin phosphorylation at serine 142 modulates the zyxin head-tail interaction to alter cell-cell adhesion.
  • Sperry R, Bishop N, Bramwell J, Carter M, Fowler B, Maxfield S, Lewis Z, Staley D, Vellinga R, Brodeur M, et alMarch, 2010. Actin-membrane linkages at adherens junctions of cell undergoing epithelial-mesenchyme transition.

Presentations

  • Coutu B, Alexander K, Hansen MD, Prince JT. Poster: Robust Lipid Fragmentation Modeling to Identify Global Lipid Changes during Epithelial-Mesenchymal Transition (EMT). ASMS Conference: 61st Conference on Mass Spectrometry and Allied Topics. June, 2013.
  • Reeder D, Bullard J, Call G, Hansen MD. AMPK regulation of VASP occurs by phosphorylation at a novel site. ASCB annual meeting. December, 2010.
  • Chung J, Davis J, Price B, Wagner M, Warner S, Bearss D, Hansen MD. Does competitive modulation of HGF signaling by accessory growth factors allow cells to select routes of metastasis?. ASCB annual meeting. December, 2010.
  • Wagner M, Reeder D, Bullard J, Hansen MD. Phosphorylation regulates the zyxin head-tail interaction. ASCB annual meeting. December, 2010.
  • Davis J, Hardman S, Hansen MD. Substrate stiffness alters cell-cell detachment during HGF-induced epithelial-mesenchymal transition. ASCB annual meeting. December, 2010.
  • Langford P, Hansen MD. Unbiased chemical screening of c-met signaling reveals the roles of novel kinases and calcium influxes. ASCB annual meeting. December, 2010.
  • Bullard J, Call G, Reeder D, Hansen MD. A zyxin-nectin interaction connects actin to the membrane of cell-cell junctions. ASCB annual meeting. November, 2010.
  • Chung J, Davis J, Price B, Wagner M, Warner S, Bearss D, Hansen MD. Does competitive modulation of HGF signaling by accessory growth factors allow cells to select routes of metastasis?. Metastasis and the tumor microenvironment. September, 2010.
  • Sperry R, Vellinga R, Lassiter R, Stark MR, Hansen MD. Zyxin regulates embryonic chick trigeminal placode morphogenesis. American Society for Cell Biology Annual Meeting. 2009.
  • A putative zyxin-nectin interaction at cell-cell contacts. ASCB. 2009.
  • An unbiased chemical screening approach to dissect c-Met signaling in EMT. ASCB. 2009.
  • Phosphorylation regulates the zyxin head-tail interaction. ASCB. 2009.
  • Zyxin regulates delamination of migratory cells during embryonic chick tri-geminal placode morphogenesis. ASCB. 2009.
  • Grange G, Ascione MPA, Thomson DM, Hansen MD. AMPK regulation of VASP occurs by phosphorylation at a novel site. American Society for Cell Biology. 2008.
  • Actin Rearrangements in Disassembly of Cadherin-Based Cell-Cell Contacts during EMT. ASCB. 2008.
  • AMPK regulation of VASP occurs by phosphorylation at a novel site. ASCB. 2008.
  • Do zyxin and LPP mediate a connection between Rho GTPAses and VASP activity?. ASCB. 2008.
  • Hierarchal autoregulation of zyxin-VASP complexes. ASCB. 2008.
  • Mechanism of zyxin targeting to cell-cell contacts. ASCB. 2008.
  • Zyxin associates with dynamic actin structures and alters cell scattering response in HGF treated MDCK cells. ASCB. 2008.
  • Control of VASP Localization and Activity by Zyxin. ASCB. 2007.
  • Role of Actin Remodeling and Cellular Contractionin Adherens Junctions Dissolution. ASCB. 2007.
  • Zyxin is a Regulator of HGF-induced Cell-Cell Dissociation in MDCK Cells. ASCB. 2007.
  • Bushnell E, Moody JD, Adams B, Bell P, Hansen MD. A Mechanism for Regulating the Activity of Zyxin-VASP Complexes. The American Society for Cell Biology, 46th Annual Meeting. December, 2006.
  • A mechanism for regulating the activity of zyxin-VASP complexes. ASCB Annual Meeting. 2006.
  • Adair MJ, Broomhead GP, Hansen MD, Hendrickson SJ, Draper RJ. Reconceptualizing Content-Area Texts, Literacies, and Instructional Strategies Symposium session presented at the National Reading Conference annual meeting, Los Angeles, CA. National Reading Conference. nrconlineorg/conferencehtml. 2006.
  • a-Actinin Links LPP, but not Zyxin, to Assembly of Cadherin-Based Junctions. American Society for Cell Biologists. 2005.
  • Zyxin and LPP-VASP Complexes Drive Cell-Cell Adhesion in Response to Rac1. American Society for Cell Biologists. 2005.
Marc Hansen