Mentored Research

Dr. Barrott, with a background in cancer pharmacology and genetics, develops personalized treatments for rare bone and muscle cancers (sarcomas) using an interdisciplinary approach. His lab tests novel anticancer therapies in various cancer models, leveraging genetic profiles to identify unique cancer vulnerabilities for targeted therapies.

The Barrow Lab at BYU focuses on developmental biology, particularly the molecular mechanisms that regulate the three-dimensional form of organs. Their research uses the embryonic vertebrate limb as a model to study gene activity and its effects on organ development.

The Bikman Lab at BYU investigates the molecular mechanisms behind disease risks associated with weight gain, focusing on insulin resistance and mitochondrial function.

The Edwards Lab at BYU studies synaptic plasticity in the hippocampus and ventral tegmental area to understand learning, memory, and reward pathways, using electrophysiology, pharmacology, molecular biology, and behavioral assays. Their research aims to apply this understanding to conditions like epilepsy, Alzheimer’s, and addiction.

Birth defects, affecting about 3% of live births in the U.S., are a leading cause of infant mortality, with neural tube defects (NTDs) being the second most common type. The lab focuses on whether inducing the transcription factor Nrf2 can protect against oxidative stress caused by teratogens, potentially reducing the prevalence of NTDs.

The lab studies gene regulation during heart formation, focusing on how gene expression transforms the heart from a linear tube to its adult shape. By combining bioinformatics and bench biology, they aim to improve the diagnosis and treatment of congenital heart disease.

The Jenkins Lab at BYU studies the utility of DNA methylation as a diagnostic tool for complex diseases such as infertility, Alzheimer’s, and cancer. Their research aims to improve early diagnosis and treatment outcomes by assessing cell-free DNA methylation signatures.

This lab uses modern neuroscience techniques, such as in vivo calcium imaging, optogenetics, electrophysiology, and computational models, to investigate the origins and functions of synchronous neural activity in rodent models. Recent projects seek to link individual-neuron-level activity of genetically distinct cortical neurons with aggregate activity recorded from large populations of neurons during sleep and administration of different general anesthetics. They also investigate the effects of local brain manipulations (e.g., stimulation of brainstem arousal areas) on synchronous activity and their potential to control levels of consciousness.

The Parrish lab is addressing key questions related to epilepsy and seizure disorders. We are particularly interested in mechanisms of endogenous inhibitory restraint and spontaneous seizure termination. Using optogenetic tools and electrophysiology, we have discovered a novel and exciting way to induce spreading depolarizations, which will allow our lab to gain new insight into these events and understand their relationship to both seizure termination and migraines.

The lab focuses on mechanisms of advanced glycation end-product (AGE) formation and RAGE receptor signaling in chronic inflammation and metabolic disease, glycation biology defenses — including the glyoxalase system, AGER1/RAGE balance, and the role of agents that mitigate glycative stress, and mitochondrial function and nitric oxide biology in respiratory and systemic health, including intermittent hypoxic training, environmental exposure, and oxidative stress

Research in the Stark Lab has previously focused on two key areas: 1) How neural tube defects like spina bifida occur during embryonic development, and 2) How various molecular and cellular pathways function to specify neuronal cell types in the developing embryo. Currently we are studying these same molecular/cellular pathways and how they function in human diseases such as fibrosis. This research includes experimental studies using cell culture along with computational analysis of large gene expression data sets, including transcriptomics, proteomics and metabolomics. We also continue to collaborate on experiments using the chick embryo model.

This lab's research focus is characterization of ligand-gated ion channels in neurotransmission. Ligand-gated ion channels are involved in normal synaptic communication and also in pathological conditions (e.g., epilepsy, Alzheimer’s disease, Parkinson’s disease, motor disorders, and schizophrenia). They are also the pharmacological targets in many therapeutic situations (e.g., general anesthetics, sedatives, antiemetics, and some novel analgesics). These ion channels are multi-subunit protein complexes that act as neurotransmitter receptors in the central and peripheral nervous systems.

Our lab uses the zebrafish model organism to study the mechanisms that oversee proper development and formation of neural circuits. A major research focus consists in learning about the development of brain regions that integrate multisensory input.

This lab studies the development of cell-to-cell communication in the nervous system. Neurons communicate with each other and with muscle through synapses, specialized sites of cell-to-cell communication. We use a combination of molecular biology, genetics, microscopy, single-cell RNA sequencing and bioinformatic methods to identify molecules involved in the formation and maintenance of proper synaptic connections. Synaptic function is impaired in a variety of neurodevelopmental and neurodegenerative disorders. A more comprehensive understanding of how synapses normally form could help determine causes of these disorders.

Our lab is focused on understanding why muscle function declines with age and how we can slow, prevent, or even reverse these changes. We aim to uncover the biological mechanisms that drive sarcopenia and use this knowledge to develop strategies that help maintain strength and physical function later in life.

Dr. Woodbury's research is in cellular and molecular physiology and focuses on membrane biophysics, particularly vesicle/membrane fusion and its regulation by SNARE proteins and alcohols. This process of exocytosis has been a target for investigators ever since the vesicular hypothesis of transmitter release was established in the 1950's. Current work focuses on structural changes in SNARE proteins due to environmental changes as measured by CD (circular dichroism, fluorescence, and mass spectrometry.

Neural Response to Food Cues after Moderate and Vigorous Exercise in Women Response Inhibition to High Caloric Food cues among Adolescents Following Active and Sedentary Video Game Play: A Randomized Crossover study

Diabetic Neuropathy Function

The Effect of Whole Body Vibration in Repositioning the Talus in Chronic Ankle Instability Populations Clinical Predictors of Movement Patterns in Patients with Chronic Ankle Instability Movement Neuromechanics in those with Ankle Instability

Ground Reaction Forces through a Range of Speeds in Steeplechase Hurdling Ground Reaction Forces for Irish Dance Landings in Hard and Soft Shoes Kinetics of Steeplechase Hurdling

Heat Induced Mitochondrial Biogenesis in Human Skeletal Muscle The Role of Multicellular Proteins in Skeletal Muscle Regeneration and Stem Cell Activity in Aged Adults

Comparison and Reliability of Methods to Assess Foot Strength The Differences in Foot Muscle Size, Toe Flexor Strength, and Time to Stability between Cheerleaders and Gymnasts Central Nervous System Activation in Blood Flow Restricted versus Non-Blood Flow Restricted Exercise

Comparison of Activity Monitors during Activities of Daily Living

Relationship between Pectoralis Minor Length, Subacromial Space, and Shoulder Pain in Swimmers and Baseball Players

Effects of Experimental Anterior Knee Pain on Knee Articular Cartilage Morphology and Composition, Lower Extremity Neuromechanics, and Blood Biomarkers

Laser to Treat Thigh Contusions of the Musculoskeletal System Establishing the Delta T Mode of the Megapulse III Rate of IM Temperature Increase during 1 & 3 MHz Ultrasound

The research group aims to decipher the process by which viruses cause diseases in humans, which is crucial for creating new vaccines and antiviral treatments. They overcome the challenge of inadequate animal models by using “humanized mice,” mice implanted with human cells that develop a human immune system, to study human viral infections and immune responses directly.

The research focuses on using bacteriophages, viruses that specifically target and destroy bacteria, as a safe and targeted alternative to antibiotics in agriculture and medicine. Since 2009, the team has isolated over 70 phages, contributed genomes to GenBank, and is working on phage cocktails to treat diseases in plants and animals, alongside promoting active learning in microbiology education.

The Davis lab, a statistical genetics lab, utilizes electronic medical records to explore the genetic underpinnings of complex diseases like multiple sclerosis (MS), aiming to elucidate the diverse clinical traits and genetic variations affecting MS. They seek to deepen the understanding of MS to improve therapeutic strategies and are inviting applications for research positions from undergraduates with relevant coursework.

The research focuses on the molecular pathogenesis and evolutionary adaptation of bacteria that cause diseases across humans and animals, aiming to tackle the public health challenge posed by bacterial infections.

The research is centered on applying molecular biology and phylogenetic analysis to comprehend biodiversity generation, evolutionary history, and includes projects on cutthroat trout, aquatic insects, diagnostic markers, ancient Egyptian genetics, American fish conservation, and the classification of thorny-headed worms.

The research is focused on symbiotic plant-microbe interactions, and we are committed to developing and sharing tools and protocols that may be of use to the broader bacterial genetics community.

The lab’s research is twofold: it examines the microbiome’s influence on ecosystem health and its disruption by pathogenic bacteria, and it explores cellular metabolic regulation, focusing on PAS kinase in yeast to understand nutrient sensing and diseases like diabetes. The team studies bacteriophages, crucial to bacterial evolution, and aims to elucidate PAS kinase’s role in metabolic regulation, which may have broader implications for understanding metabolic diseases in complex organisms.

Current research interests include business aspects of research lab management and aspects of technology transfer and intellectual properties in science.

[Past Research]
Nanoinjector Device, Honeybee Conservation, Canker Sores, Parkinson's Disease

The lab studies the intricate architecture of chromatin, focusing on how nucleosome positioning—affected by DNA sequence—affects gene expression, using advanced sequencing technologies and models like C. elegans to potentially inform gene therapy in humans. Their work aims to manipulate gene expression by altering DNA sequences that dictate nucleosome arrangement, which could address gene silencing issues in DNA-based treatments.

The lab is at the forefront of cancer research, focusing on early detection through a patented serum tumor marker and the discovery of additional biomarkers for immunotherapies like CAR T cell therapy. Their work spans enhancing the body’s immune defenses against cancer, developing vaccines, studying tumor-associated macrophages, and advancing CAR T cell immunotherapy to improve patient outcomes.

The research aims to enhance our understanding of infectious diseases by employing big data analytics to study mRNA changes in human cells during disease and by conducting comparative genomics to examine pathogen mutations. These approaches are expected to improve strategies for priming the immune system and modulating host responses to reduce mortality and bolster human health.

The research investigates the complex interplay of genetic, environmental, and hormonal factors in systemic lupus erythematosus, focusing on the IRF5 gene’s variations that may lead to the disease by disrupting cellular pathways and increasing interferon production. Additionally, the lab studies how Epstein-Barr and Herpes Simplex viruses influence gene expression, which could further illuminate the molecular mechanisms behind lupus.

The research is centered on understanding how bacterial pathogens, including CDC select agents and species within the genera Streptococcus, Pasteurella, and Mycobacterium, evade immune defenses and cause diseases in humans and animals, with a focus on developing detection methods like real-time PCR assays. Additionally, the lab is engaged in researching decontamination and disinfection strategies, including natural products that can combat pathogens or boost the immune system to prevent disease.

Diabetes Research Group

Led by Dr. Scott Weber, the lab is dedicated to molecularly understanding and enhancing the immune response against diseases such as cancer, autoimmune disorders, asthma, and Alzheimer's.

Dr. Wilson’s lab at BYU, with a rich background in immunology and microbiology, now focuses on host-pathogen interactions, particularly the role of nutritional immunity in infections and the microbiome’s influence on pathogen carriage. The lab collaborates extensively, including with Dr. Jovanka Voyich’s lab at Montana State University, on projects funded by NIH grants and works with various departments at BYU on related research.

The Hancock Lab focuses on understanding how changes in energy supply and demand impact metabolic pathways, particularly in relation to insulin resistance and type 2 diabetes. Their research includes studying the effects of lifestyle, bioactive compounds, and various interventions on energy metabolism and glucose management to improve prevention and therapy for diabetes and related conditions.

The Nutrition Assessment Lab at BYU aims to evaluate and improve nutritional status and health outcomes through advanced assessment techniques and research. They focus on understanding the impact of nutrition on health and developing effective strategies for nutritional interventions.

The Sensory Lab at BYU focuses on evaluating the sensory attributes of food, such as taste, odor, and texture, through various testing methods. The lab is equipped with advanced facilities to conduct difference testing, preference testing, and descriptive analysis to support research and product development.

The Ben Abbott Lab at BYU investigates how human activities impact water and nutrient cycles essential for life on Earth. Their research spans water chemistry in permafrost regions, water stewardship in various landscapes, and the renewable energy revolution.

The BYU Life Sciences Greenhouse is a 20,000 sqft facility built in 2011, designed for both research and teaching. It supports diverse plant collections and provides space for breeding programs, environmental science, and landscape management research.

The Robinson Lab at BYU conducts research on the physiology and nutrition of domestic and wild animals, with a particular focus on camelids like llamas and alpacas. Their studies aim to improve understanding of these animals’ dietary needs and overall health.

The Cheatgrass Research Lab at BYU studies the genetics and ecological impact of cheatgrass, an invasive weed in western North America. Their research aims to understand genetic diversity and develop management strategies to reduce its spread and ecological damage.

The Chaston Lab at BYU studies the interactions between hosts and their microbiomes, focusing on how these relationships affect health and disease. Their research includes examining the microbiota of fruit flies and humans to understand microbial influences on host physiology and behavior.

The Orphaned Crops Lab at BYU focuses on underutilized or “orphaned” plant species that have the potential to diversify global food sources beyond the dominant crops like maize, wheat, and rice. Their research aims to explore the genetic diversity and agricultural potential of these neglected species to enhance food security and ecosystem resilience.

The Orphaned Crops Lab at BYU focuses on underutilized or “orphaned” plant species that have the potential to diversify global food sources beyond the dominant crops like maize, wheat, and rice. Their research aims to explore the genetic diversity and agricultural potential of these neglected species to enhance food security and ecosystem resilience.

The Wildlife Ecology Research Lab at BYU focuses on understanding wildlife populations and their habitats, with projects including the Northern Utah Fawn Study and the recovery of Greater Sage-Grouse. Their research aims to inform conservation and management strategies for various wildlife species.

The Madsen Lab at BYU focuses on improving rangeland resilience to disturbances like wildfires and resistance to invasive species through innovative seed coating technology. Their research aims to restore scorched landscapes with native, fire-resistant plants.

The Orphaned Crops Lab at BYU focuses on underutilized or “orphaned” plant species that have the potential to diversify global food sources beyond the dominant crops like maize, wheat, and rice. Their research aims to explore the genetic diversity and agricultural potential of these neglected species to enhance food security and ecosystem resilience.

The Wildlife Ecology Research Lab at BYU focuses on understanding wildlife populations and their habitats, with projects including the Northern Utah Fawn Study and the recovery of Greater Sage-Grouse. Their research aims to inform conservation and management strategies for various wildlife species.

The Neil Hansen Lab at BYU focuses on water use and conservation in agricultural and natural systems, including dryland and limited irrigation agroecosystems. Their research aims to protect water quality through effective land management practices.

The Paul Frandsen Lab at BYU uses bioinformatics and data science to study genomic processes that generate and maintain biodiversity, with a particular focus on insects. Their research includes evolutionary history, phylogenetics, and comparative genomics.

The Geospatial Habitat Analysis Lab at BYU uses geospatial technology to map and analyze forest and range environments. Their research includes projects on aspen ecology, fire severity, sagebrush ecology, and tropical ecosystem modeling.

The St. Clair Lab at BYU studies plant ecology, focusing on how plant-environment interactions influence community development and ecosystem stability. Their research covers disturbance and invasion ecology, plant-animal and plant-plant interactions, plant-soil feedbacks, and global change biology, primarily in forest and desert ecosystems of western North America.