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Brian Poole

Associate Professor
Microbiology and Molecular Biology Faculty, Microbiology & Molecular Biology

3138 LSB
Provo, UT 84602

Research Interests

Systemic lupus erythematosus is a common, debilitating autoimmune disease in which components of the body’s own cells are targeted and attacked by the immune system. The origins of the disease are still unclear, but it is known that genetic, environmental, and hormonal factors are all involved in causing lupus. We are studying the interactions of genetic risk factor and the putative environmental factor Epstein-Barr virus (EBV). Considerable evidence indicates that EBV infection is associated with lupus. The major question with this finding is that nearly everyone has been infected with EBV, while very few of those people will go on to develop lupus. The genetic background of the person may play a key role in deciding the outcome of the infection.

Although there is a strong genetic component to lupus, not much is known about how genes influence the development of the disease. We are focusing on lupus-associated variations in the IRF5 gene. The IRF5 protein is a key intermediary in the response to viral infection, and interacts with EBV during the course of the EBV infection. We hypothesize that the modifica¬tions to the IRF5 gene associated with lupus cause aberrant activation of EBV and heightened response to EBV infection, potentially leading to the altered immune response to EBV seen in lupus patients and people at risk for lupus.

Through studying these interactions, we hope to identify markers for people who are at high risk for lupus, and early indicators that autoimmunity is developing. Early intervention in the disease has shown promise in slowing its effects.

Education

  • Ph.D., , Pennsylvania State University (2004)
  • B.S., Microbiology , Brigham Young University (1999)

Honors and Awards

  • Phi Kappa Phi Election, Phi Kappa Phi National Honor Society (2018 - Present)
  • Alcuin Fellow, BYU Honors (2017 - 2019)
  • College Outstanding Teaching Award, College of Life Sciences (2018 - 2018)
  • Research Recognition Award, Lupus Foundation of America-Utah Chapter (2017 - 2017)
  • Fulbright Scholar, Fulbright Organization (2016 - 2016)

Memberships

  • American College of Rheumatology (2012 - Present)

Professional Citizenship

  • Editor, Associate Editor, Vaccines Journal (2021 - Present)
  • Grant Proposal Reviewer, External, Fulbright Organization (2019 - Present)
  • Guest Speaker, National Court Appointed Special Advocate/Guardian Ad Litum Association for Children (2021 - 2021)
  • Reviewer, Ad Hoc Reviewer, Hong Kong Food and Health Bureau (2020 - 2021)
  • Publications-outreach, BYU Public Health (2020 - 2020)
  • Grant Proposal Reviewer, External, CDRMP/Department of Defense (2020 - 2020)
  • Grant Proposal Reviewer, External, Hong Kong Food and Health Bureau (2020 - 2020)
  • Other, Peterson for Utah (2020 - 2020)
  • Grant Proposal Reviewer, External, Binational Fulbright Commision in Egypt (2020 - 2020)
  • Publications-outreach, Brigham Young University (2020 - 2020)
  • Guest Speaker, Lupus foundation of America Utah Chapter (2020 - 2020)
  • Committee/Council Chair, Lupus Foundation of America, Utah Chapter (2016 - 2019)
  • Grant Proposal Reviewer, External, CDRPM/Department of Defense (2019 - 2019)
  • Grant Proposal Reviewer, External, CDMRP (Department of Defense Grant organization) (2016 - 2016)
  • Reviewer, Ad Hoc Reviewer, ORCA grant reviewer (2009 - 2011)
  • Editor, Associate Editor, Journal of Biomedicine and Biotechnology (2009 - 2011)
  • Reviewer, Ad Hoc Reviewer, MEG grant reviewer (2008 - 2009)
  • Reviewer, Ad Hoc Reviewer, ORCA grant reviewer (2008 - 2009)

Courses Taught

Publications

Margarida Figueiredo-Braga Beatriz Silva Sara Ganhão Francisca Aguiar Caleb Cornaby Iva Brito Brian Douglas Poole Laura J Westhoff Samantha J Hughes Erin Gill Trent Walker Abraham Quaye Bradford K Berges Brian Douglas Poole Federico Ciardi Vidya Menon Jamie L Jensen Masood A. Shariff Anjana Pillai Usha Venugopal Moiz Kasubhai Vihren Dimitrov Balavenkatesh Kanna Brian Douglas Poole Benjamin Ogilvie Antonio Solis-Leal J Brandon Lopez Brian Douglas Poole Richard A Robison Bradford K Berges D K Johnson K M Reynolds Brian Douglas Poole M D Montierth V M Todd A Barnado Mary Feller Davis Kendall Pogue Jamie L Jensen Carter K. Stancil Daniel G. Ferguson Savannah J. Hughes Emily J. Mello Ryan Burgess Bradford K Berges Abraham Quaye Brian Douglas Poole Benjamin Walter Abbott John M Chaston Jonas Bush Chantel D Sloan Brian Douglas Poole Mitchell Greenhalgh S. Isaac St. Clair Haley Moon Jacob E Gudmundsen Sarah Gottfredson Isabella M. Errigo Skyler Lemmon Sandra Hope Brian Douglas Poole Deborah K. Johnson Emily J. Mello Trent D. Walker Spencer J. Hood Jamie L Jensen Brian Douglas Poole Margarida Figueiredo-Braga Caleb Cornaby Alice Cortez Miguel Bernardes Georgina Terroso Marta Figueiredo Cristina Mesquita Lucia Costa Brian Douglas Poole Margarida Figueiredo-Braga Caleb Cornaby Alice Cortez Miguel Bernardes Georgina Terroso Marta Figueiredo Cristina Mesquita Lucia Costa Brian Douglas Poole Margarida Figueiredo-Braga Caleb Cornaby Mario Bernardes Marta Figueiredo Cristina Mesquita Lucia Costa Brian Douglas Poole Caleb Cornaby Jilian L. Jafek Cameron Birrell Vera Mayhew Lauren Syndergaard Jeffrey Mella Wesley Cheney Brian Douglas Poole Caleb Cornaby Anne Tanner Eric W Stutz Brian Douglas Poole Bradford K Berges Caleb Cornaby Lauren Gibbons Vera Mayhew Chad S. Sloan Andrew Welling Brian Douglas Poole Daniel N. Clark R. Daniel Read Vera Mayhew Stephen C. Petersen Lance A. Stutz Lissenya B. Argueta Rodney E. Till Sean M. Bergsten Brandon S. Robinson Douglas G. Baumann J. Casey Heap Brian Douglas Poole Daniel N. Clark R. D. Read Vera Mayhew Stephen C. Petersen Lissenya B. Argueta Lance A. Stutz Rodney E. Till Sean M. Bergsten Brandon S. Robinson Douglas G. Baumann J. C. Heap Brian Douglas Poole Daniel N. Clark Jillian L. Markham Chad S. Sloan Brian Douglas Poole Brian Douglas Poole Timothy Neiwold George Tsokos Daniel N Clark Brian Douglas Poole Joel Guthridge Daniel N. Clark Amanda Templeton Nicolas Dominguez Rufei Lu Gabriel Vidal Jennifer A. Kelley Kenneth Kauffman John B. Harley Patrick Gaffney Judith A. James Brian Douglas Poole Daniel N. Clark Brian Douglas Poole Tyler J. Hedman Daniel V. Hammond Daniel S. Catts Amanda Stewart F Brent Johnson Brian Douglas Poole Timothy B. Niewold George C. Tsokos Charles S. Via Brian Douglas Poole Violetta Kivovich Leona Gilbert Stanley J. Naides Brian Douglas Poole Timothy B. Niewold Daniel N. Clark Rafah Salloum Brian Douglas Poole Amanda Templeton N. Dominguez R. Lu G. S. Vidal J. Levin A. S. Sestak J. A. Kelly K. M. Kaufman G. R. Bruner P. M. Gaffney J. B. Harle Brian Douglas Poole R. I. Schneider J. M. Guthridge C. A. Velte M. Reichlin J. B. Harley J. A. James Brian Douglas Poole Amanda K. Templeton Joel M. Guthridge Eric J. Brown John B. Harley Judith A. James Brian Douglas Poole T. Gross S. Maier J. B. Harley J. A. James Brian Douglas Poole Judith A. James Brian Douglas Poole J. Zhou A. Grote A. Schiffenbauer S. J. Naides Brian Douglas Poole R. H. Scofield J. B. Harley J. A. James Brian Douglas Poole M. T. McClain K. M. Bruner BF Kaufman J. B. Harley J. A. James Brian Douglas Poole Y. V. Karetnyi S. J. Naides

Presentations

Brian Douglas Poole
Brian Douglas Poole
Brian Douglas Poole Deborah K Johnson Kaylia M. Reynolds Vera M Todd April Barnado Mary Feller Davis
Brian Douglas Poole Margarida Figueiredo-Braga
Brian Douglas Poole Margarida Figeuredo-Braga
Abraham Quaye Brandon Ord KJ VanderWerff Brian Douglas Poole
Brian Douglas Poole Laura J. Westhoff Erin Gill Savannah Hughes Trent Walker
Brian Douglas Poole Caleb Cornaby Margarida Figueredo-Braga
Emily Mello Deborah K Johnson Trent Walker Spencer Hood Jamie L Jensen Brian Douglas Poole
Kala Harbaugh Margarida Figueredo-Braga Caleb Cornaby Brian Douglas Poole
Brian Douglas Poole
Brian Douglas Poole Margarida Figueiredo-Braga
Brian Douglas Poole
Brian Douglas Poole Caleb Cornaby Kalare Eberting Wesley Cheney Grant Walker Craig Smith Tosh Dowling Emily Mello
Brian Douglas Poole
Brian Douglas Poole
Brian Douglas Poole Caleb Cornaby Cameron Birell
Jeffrey Mella Chad Sloan Daneil Clark Brian Douglas Poole
Rodney Till Daniel Clark Brian Douglas Poole
Daniel Catts Jared Lambert Lissenyi Argueta May Pham Trieste Bills Brian Douglas Poole
Lissenyi Argueta Jared Lambert Brian Douglas Poole
Richard Read Brian Douglas Poole
Brian Douglas Poole Rodney Till
Daniel N. Clark Brian Douglas Poole
Brian Douglas Poole Daniel N. Clark Brandon Henrie Jason Sloan Douglas Baumann Casey Heap Trieste Bills Kathryn E. Greenhalgh Daniel Read Sean Bergsten Marinya Roznick
Daniel Read Jared Lambert Brandon Henrie Jason Sloan Doug Baumann Casey Heap Sean Bergsten Brian Naylor Daniel N. Clark Trieste Bills Brian Douglas Poole
Danny S. Catts Tyler J. Hedman Daniel N. Clark Brian Douglas Poole Daniel V. Hammond Brian D. Poole F Brent Johnson
Brian Douglas Poole Kathryn Greenhalgh
Jason Sloan Brandon Robinson Sean Bergsteb Brian Douglas Poole
Daniel Hammond F Brent Johnson Daniel N. Clark Brian Douglas Poole
Daniel N. Clark Brandon Henrie Brian Douglas Poole
Brian Douglas Poole Amanda Templeton G. Lu R. Vidal J. Levin A. Sestak J. Kelly K. Kauffman G. Bruner P. Gaffney J. Harley J. James J. Guthridge
Brian Douglas Poole
Brian Douglas Poole Amanda Templeton N. Dominguez R. Lu G. S. Vidal J. Levin A. S. Sestak J. A. Kelly K. M. Kaufman G. R. Bruner P. M. Gaffney J. B. Harley J. A. James J. M. Guthridge
Brian Poole