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Chad Hancock

Associate Professor
Nutrition, Dietetics & Food Science

S 245 ESC
Provo, UT 84602

(801) 422-7588

Research Interests

My research focus is on metabolic pathways impacted by changes in energy supply and demands. Factors that contribute to insulin resistance and type 2 diabetes are most often a result of a mismatch between metabolic fuel supply (the food energy that we eat) and metabolic fuel demands (the food and stored energy that we burn through activity). We study energy metabolism and factors contributing to the development of insulin resistance using nutritional, exercise and pharmaceutical approaches.

Our general research objectives include the following:

  • Understand mechanisms by which lifestyle and other factors contribute to the development of insulin resistance.
  • Investigate the effects of different bioactive compounds on glucose management and energy metabolism.
  • Explore mechanisms by which various bioactive compounds impact glucose management and energy metabolism.

This research is vitally important to gain a better understanding of the metabolic problems that underpin many chronic diseases impacted by insulin resistance. We expect our work can lead to improved prevention and therapy for diabetes and related disease conditions.

Recent projects of interest include:

  • A study looking at the effect of dietary selenium and/or increased isoflavones on insulin resistance and baseline glucose management.
  • A study examining the effect of caloric restriction on mitochondrial content.
  • A study examining the effect of iron deficiency and specific enzymatic responses to this energy challenge.
  • A study examining the effect of high fat diets as well as the activation of a critical enzyme involved in energy sensing (AMPK) on muscle mitochondrial content and capacity.
  • A study looking at the effect of high fat diets and activating AMPK on liver fat accumulation.

Current projects of interest include:

  • Examining a potential role of cellular iron dysregulation and insulin resistance.
  • Exploring the effects of specific bioactive compounds on muscle and hepatic iron metabolism.
  • We are examining the possibility that some anti-diabetic therapies may be effective at reducing unwanted toxicities associated with certain chemotherapeutic treatments.
  • Exploring the impact of different dietary bioactive compounds on mitochondrial function and the generation of reactive oxygen species.

Experience

Academic - Post-Secondary

  • Associate Professor, NDFS, 2014-Present

Professional

  • Assistant Professor, NDFS, 2008-2014
  • Instructor-Nutrition and Dietetics, St. Louis University-Doisy College of Health Sciences, 2008-2008
  • Editorial Board Member, American Journal of Physiology-Endocrinology and Metabolism, 2007-2008
  • Postdoctoral Fellow, Washington University in St. Louis-School of Medicine, 2005-2008

Memberships

  • American Diabetes Association, 2008-Present
  • The American Physiological Society, 2008-Present

Honors & Awards

  • American Physiological Society : APS Publications 2015 Star Reviewer

Courses Taught
Winter 2019

  • NDFS 100: Essentials of Human Nutrition Section 003
  • NDFS 310: Nutr & Metab Sports Exercise Section 001
  • NDFS 494R: Undergrad Research in N D F S Section 007
  • NDFS 602: Advanced Human Nutrition 2 Section 002
  • NDFS 691R: Graduate Seminar Section 001

Fall 2018

  • NDFS 310: Nutr & Metab Sports Exercise Section 001
  • NDFS 494R: Undergrad Research in N D F S Section 005
  • NDFS 691R: Graduate Seminar Section 001

Summer 2018

  • LFSCI 199R: Nonresearch Academic Internshp Section 003
  • NDFS 691R: Graduate Seminar Section 001

Spring 2018

  • NDFS 310: Nutr & Metab Sports Exercise Section 001
  • NDFS 494R: Undergrad Research in N D F S Section 006
  • NDFS 691R: Graduate Seminar Section 001

Publications

Journal Articles

Koh J, Hancock CR, Han DH, Holloszy JO, Nair KS, Dasari S. 2019. AMPK and PPARβ positive feedback loop regulates endurance exercise-mediated GLUT4 expression in skeletal muscle.

Mackay AD, Marchant ED, Munk DJ, Watt RK, Hansen JM, Thomson DM, Hancock CR. 2019. Multi-Tissue Analysis of Exercise or Metformin on Doxorubicin-Induced Iron Dysregulation.

Kener KB, Munk DJ, Hancock CR, Tessem JS. 2018. High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds. J. Vis. Exp. 131.

Tueller DJ, Harley JS, Hancock CR. 2017. Effects of curcumin and ursolic acid on the mitochondrial coupling efficiency and hydrogen peroxide emission of intact skeletal myoblasts. Biochemical and Biophysical Research Communications.

Koh JH, Hancock CR, Terada S, Higashida K, Holloszy JO, Han DH. 2017. PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise. Cell Metabolism.

Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS. 2016. β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. 311(1):E186-201.

Chen T, Moore TM, Ebbert MT, McVey NL, Madsen SR, Hallowell DM, Harris AM, Mackay RP, Char RE, Hancock CR, et al. 2016. Liver kinase B1 inhibits the expression of inflammation-related genes post-contraction in skeletal muscle. Journal of applied physiology. 120(8):876-888.

Hardman SE, Hall DE, Cabrera AJ, Hancock CR, Thomson DM. 2014. The effects of age and muscle contraction on AMPK activity and heterotrimer composition. Experimental Gerontology. 55:120-128.

Stallings MT, Cardon BR, Hardman JM, Bliss TA, Brunson SE, Hart CM, Swiss MD, Hepworth SD, Christensen MJ, Hancock CR. 2014. A high isoflavone diet decreases 5′ adenosine monophosphate–activated protein kinase activation and does not correct selenium-induced elevations in fasting blood glucose in mice. Nutrition Research.

Bridgewater LC, Mayo JL, Evanson BG, Whitt ME, Dean SA, Yates JD, Holden DN, Schmidt AD, Fox CL, Dhunghel S, et al. 2013. A novel bone morphogenetic protein 2 mutant mouse, nBmp2NLStm, displays impaired intracellular Ca2+ handling in skeletal muscle. BioMed Research International. 2013.

Henriksen BS, Curtis ME, Fillmore N, Cardon BR, Thomson DM, Hancock CR. 2013. The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding. Diabetology & Metabolic Syndrome. 5(1).

Merrill JF, Thomson DM, Hardman SE, Hepworth SD, Willie S, Hancock CR. 2012. Iron deficiency causes a shift in AMP-activated protein kinase (AMPK) subunit composition in rat skeletal muscle. Nutr Metab. 9(1).

Erickson KA, Smith ME, Anthonymuthu TS, Brassfield ES, Tucker BJ, Prince JT, Hancock CR, Bikman BT. 2012. AICAR inhibits ceramide biosynthesis in skeletal muscle. Diabetology and Metabolic Syndrome. 4(45):1-7.

Han D, Hancock CR, Jung SR, Higashida K, Kim SH, Holloszy JO. 2011. Deficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance. Plos One. 6(5):e19739.

Brown JD, Hancock CR, Mongillo AD, Barton BJ, Digiovanni RA, Parcell AC, Winder WW, Thomson DM. 2011. Effect of LKB1 deficiency on mitochondrial content, fiber type, and muscle performance in the mouse diaphragm. Acta Physiologica. 201(4):457-466.

Hancock CR, Han DH, Higashida K, Kim SH, Holloszy JO. 2010. Does calorie restriction induce mitochondrial biogenesis? A reevaluation. FASEB J. 25.

Thomson DM, Hancock CR, Evanson BG, Kenney SG, Mallan BB, Mongillo AD, Brown JD, Hepworth S, Fillmore N, Parcell AC, et al. 2010. Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice. J Appl Physiol. 108:1775-1785.

Presentations

Abbott K, Hafen PS, Bowden J, Lopiano R, Hancock CR, Hyldahl RD. Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. SWACSM. Costa Mesa, CA. 2018.

Hyldahl RD, Gifford JR, Parcell AC, Hancock CR, Davidson LE, Mack GW. Physiological assessment of a 16-day, 4,385 km ultra-endurance mountain bike race: a case study. SWACSM. Costa Mesa, CA. 2018.

Anderson JG, Symkins DD, Hans RC, Hancock CR. Curcumin Alters Iron Regulation in C2C12 Skeletal Muscle Cells and Prevents Iron Accumulation in a Model of Elevated Oxidative Stress. Experimental Biology. San Diego. 2018.

Marchant ED, Mackay AD, Munk DJ, Hancock CR. Exercise or Metformin Modulates Doxorubicin Mediated Iron Dysregulation in Liver, Heart and Skeletal Muscle. Experimental Biology. San Diego. 2018.

Mackay AD, Hancock CR. Exercise, but Not Metformin Prevents Muscle Function Loss Due to Doxorubicin in Mice Using an in-Situ Model. Experimental Biology. San Diego. 2018.

Anderson JG, Hans RC, Symkins DD, Hancock CR. Hydrogen Peroxide Causes Iron Dysregulation in C2C12 Skeletal Muscle Cells. Experimental Biology. San Diego. 2018.

Harley JS, Mackay AD, Hancock CR. Metformin Restores Doxorubicin Induced Reduction in Complex II Respiration in C2C12 Skeletal Muscle Myotubes. Experimental Biology. San Diego. 2018.

Anderson JG, Munk DJ, Johnson JM, Wright DC, Hancock CR. Hepatic Iron Regulation in Two Models of Insulin Resistance. American Diabetes Association-Scientific Sessions. San Diego, CA. 2017.

Hafen PS, Hancock CR, Hyldahl RD. Deep tissue heating increases mitochondrial respiratory capacity of human skeletal muscle. ACSM National Meeting. Denver, CO. 2017.

Klabacka R, Crandall A, Anderson J, Wright DC, Hancock CR. Analysis of Iron Dysregulation in High-Fat and Iron Deficient Rat Models. Experimental Biology. San Diego, CA. 2016.

Louw MJ, Crandall AD, Murphy TS, Reynolds MS, Bernhisel D, Hancock CR. Exercise Limits Loss of Respiratory Function Seen with Doxorubicin Treatment without Affecting Muscle Function. Experimental Biology. San Diego, CA. 2016.

Murphy TS, Crandall AD, Louw MJ, Bernhisel D, Reynolds M, Hancock CR. Metformin Limits Loss of Mitochondrial Respiration Seen With Doxorubicin Treatment Without Affecting Muscle Function. Experimental Biology. San Diego, CA. 2016.

JOHNSON JM, SMITH DH, WRIGHT DC, WATT R, Hancock CR. Rosiglitazone Ameliorates Iron Dysregulation in Livers from ZDF Rats. American Diabetes Association-Scientific Sessions. Boston, MA. 2015.

Mayo JL, Nichols BA, Olsen DS, Cordner RD, Hancock CR, Weber KS, Wilson E, Edwards JG, Barrow JR, Bridgewater LC. The nBMP2 mutant mouse shows defects in intracellular calcium transport-regulated pathways. Southwest Regional Meeting of the Society for Developmental Biology. Aurora, Colorado. 2014.

Hancock CR. “Changes in skeletal muscle oxidative capacity in response to chronic AMPK activation and elevated dietary fat.”. Southwest Chapter of the American College of Sports Medicine Meeting. Newport Beach, CA. 2013.

Hardman SE, Merrill JF, Thomson DM, Hancock CR. The effect of iron deficiency on AMPK subunit isoform composition in skeletal muscle. Experimental Biology. Boston, MA. 2013.

Cardon BR, Stallings MT, Brunson SE, Hart CM, Swiss MD, Hepworth SD, Christensen MJ, Hancock CR. Dietary isoflavones and supplemental selenium show interactive effects on blood-glucose homeostasis in male FVB mice. Experimental Biology. San Diego, CA. 2012.

Stallings MT, Hardman JM, Hart CM, Christensen MJ, Hancock CR. Fiber-type skeletal muscle response to dietary selenium and isoflavone supplementation in male mice. Experimental Biology. San Diego, CA. 2012.

Merrill JF, Hepworth SD, Willie S, Winder WW, Thomson DM, Hancock CR. Iron deficiency causes a shift in AMP-activated protein kinase (AMPK) catalytic subunit composition in rat skeletal muscle. Experimental Biology. San Diego, CA. 2012.

Curtis M, Henriksen B, Fillmore N, Winder WW, Thomson DM, Hancock CR. Chronic activation of AMPK limits hepatic triglyceride accumulation independent of changes in total glycerol-3-phosphate-acyltransferase activity. Experimental Biology. Washington, DC. 2011.

Thomson DM, Hancock CR, Evanson BG, Kenney SG, Malan BB, Mongillo AD, Brown JD, Hepworth S, Fillmore N, Parcell AC, et al. Muscle-specific LKB1 knockout leads to skeletal muscle dysfunction. FASEB Summer Research Conference- AMPK:Central Regulatory System in Metacolism & Growth. Kyoto, Japan. 2010.