One in every 33 live births presents with a birth defect. Unfortunately, the mechanistic origins of the majority these developmental abnormalities remain largely unknown. Interestingly, many of the environmental and chemical insults that promote dysmorhpogenesis are known inducers of oxidative stress, commonly defined as the imbalance of compartmentalized oxidizing and reducing equivalents where the former predominates. Oxidative stress at high levels promotes damage to proteins, DNA and lipids resulting in cell death. Yet at lower levels, oxidative stress can disrupt redox-sensitive cellular signaling, including those that are specific to support normal developmental events, such as proliferation, differentiation and apoptosis. Our laboratory focuses on better understanding the mechanisms of oxidative stress-induced birth defects through various in vivo (animal models) and in vitro (whole embryo culture and stem cell) models. Moreover, we are developing interventions that will serve to protect the developing embryo from oxidative insults and thus, decrease the incidence of birth defects.
Teaching Interests
PDBio 305: Basics of Human Physiology PDBio 550R: Human Toxicology
Education
Toxicology, , University of Michigan (2001)
Zoology, Developmental Biology , Brigham Young University (1997)
Zoology, Human Biology , Brigham Young University (1994)
Honors and Awards
Toxicological Sciences Paper of the Year, Society of Toxicology
(2017 - 2017)
Memberships
Society for Redox Biology and Medicine (2016 - Present)
Committee/Council Member, Teratology Society (2013 - 2016)
Committee/Council Chair, Teratology Society (2014 - 2015)
Courses Taught
Publications
C M WaltonE R SaitoC E WarrenJ G LarsenN P RemundPaul Rulon ReynoldsJason Merrell HansenBenjamin Thomas BikmanA GolubkovaT LeivaK SnyderC SchlegelS M BonvicinoM P AgbagaR S BrushJason Merrell HansenP F VitielloC J HunterB M DaviesJ K KatayamaJ E MonsivaisJ R AdamsM E DiltsA L EbertingJason Merrell HansenS C DixonB J CalderS M LilyaB M DaviesA MartinM PetersonJason Merrell HansenArminda SuliT B PiorczynskiS LapehnK P RingerS A AllenG A JohnsonK CallS M LucasC HarrisJason Merrell HansenT B PiorczynskiM W LarsenS J LeeJason Merrell HansenJason M HansenS Marc LucasCatania D RamosEli J GreenDakota J NuttallDavid S ClarkErik D MarchantChad R HancockTed B PiorczynskiE S KruegerJ L BealesK B RussonW S ElisonJ R DavisJason Merrell HansenA P NeilsonJason Merrell HansenJeffery S TessemT B PiorczynskiM W LarsenS J LeeJason Merrell HansenS LapehnT B PiorczynskiJason Merrell HansenC HarrisM E RobbinsH Y ChoJason Merrell HansenJ R LuchsingerM L LocyM VeltenS R KleebergerL K RogersT E TippleC S CarterS C HuangC C SearbyB CassaidyM J MillerW J GrzesikT B PiorczynskiT K PakS A WalshM AcevedoQ ZhangK A MapuskarG L MilneA O Hinton, JrD F GuoR WeissK BradberryE B TaylorA J RauckhorstD W DickV AkurathiK C Falls-HubertB A WagnerW A CarterK WangA W NorrisK RahmouniG R BuettnerJason Merrell HansenD R SpitzE D AbelV C SheffieldJason Merrell HansenJoshua MonsivaisBrandon DaviesT ChenJonathon T HillT M MooreCheung ECKZ E OlsenT B PiorczynskiT D MarriottJeffery S TessemChase M WaltonBenjamin Thomas BikmanJason Merrell HansenDavid Morley ThomsonJason Merrell HansenWinn LouiseJason Merrell HansenMicah M RossTed B PiorczynskiJamison HarveyTyson S BurnhamMorgan FrancisMadison W. LarsonKyle RoeJason M HansenMichael R StarkJason Merrell HansenJason Merrell HansenA D MackayE D MarchantD J MunkRichard Kent WattJason Merrell HansenDavid Morley ThomsonChad R HancockA R Timme-LaragyM E HahnJason Merrell HansenA RastogiM A RoyK P RingerM G RothM S GareyT B PiorczynskiArminda SuliJason Merrell HansenJonathan Kimball AlderT J Rowley, 4thB F BitnerJ D RayD R LathenA T SmithsonB W DallonC J PlowmanBenjamin Thomas BikmanJason Merrell HansenM R DorenkottK M GoodrichL YeS F O'KeefeA P NeilsonJeffery S TessemK E SantJason Merrell HansenL. Tom WilliamsN L TranJ V GoldstoneJ J StegemanM E HahnA Timme-LaragyG K ReidA J BerardinelliL RayA R JacksonA S NeishJason Merrell HansenP W DenningS A MolinaH K MoriartyD T InfieldB R ImhoffR J VanceA H KimJason Merrell HansenW R HuntM KovalN A McCartyJason M HansenChase J PlowmanTed B PiorczynskiM L BoozeJason Merrell HansenP F VitielloW R HuntB R HelfmanN A McCartyJason Merrell HansenY ShimizuC K NicholsonJohanna Caroline LambertL A BarrN KuekD HerszenhautL TanT MuroharaJason Merrell HansenA HusainN NaqviJ W CalvertTing ChenTimothy M MooreMark T EbbertNatalie L McVeySteven R MadsenDavid M HallowellAlex M HarrisRyan P MackayRobin E CharChad R HancockJason Merrell HansenJohn Sai Keong KauweDavid Morley ThomsonS GhoshC A IhunnahR HazraA L WalkerJason Merrell HansenD R ArcherA T Owusu-AnsahS F Ofori-AcquahC HarrisJ L JilekK E SantJ PohlM ReedJason Merrell HansenJ L JilekK E SantK H ChoM S ReedJ PohlJason Merrell HansenC HarrisJason Merrell HansenC HarrisC A Easley, 4thJ M BradnerA MoserC A RickmanZ T McEachinM M MerrittJason Merrell HansenW M CaudleC A DownsL KreinerX M ZhaoP TracN M JohnsonJason Merrell HansenL A BrownM N HelmsJason M HansenW R HuntS M ZughaierD E GuentertM A ShenepM KovalN A McCartyJason Merrell HansenA R Timme-LaragyJ V GoldstoneB R ImhoffJ J StegemanM E HahnJason Merrell HansenClaudia W HarrisD Z ShusterR Roman GomezK E SantJ PohlJason Merrell HansenA S KathiriaM A ButcherJason Merrell HansenA L TheissJason Merrell HansenCraig HarrisA M SioreR E ParkerC CuppelsN ThornJason Merrell HansenA A StecenkoK L BrighamCraig HarrisJason Merrell HansenJason Merrell HansenCraig HarrisJason Merrell HansenJason Merrell HansenJ R RoedeJason Merrell HansenY M GoDean P JonesB R ImhoffJason Merrell HansenJ WuJason Merrell HansenL HaoR N TaylorN SidellLane FischerA IgoudjilJ MagranéY Li Jason Merrell HansenG ManfrediJ D GlassB R ImhoffJason Merrell HansenB R ImhoffJason Merrell HansenB R ImhoffJason Merrell HansenT E TippleS E WeltyL D NelinJason Merrell HansenLynette RogersJ M KleinhenzD J KleinhenzS YouJ D RitzenthalerJason Merrell HansenD R ArcherR L SutliffMichael HartP W LinL E MyersL RayS C SongT R NasrA J BerardinelliK KunduN MurthyJason Merrell HansenA S NeishJ D WidderD FraccarolloP GaluppoJason Merrell HansenDean JonesG ErtlJ BauersachsA L TheissM Vijay-KumarT S ObertoneDean JonesJason Merrell HansenA T GewirtzD MerlinS V SitaramanN Gletsu-MillerJason Merrell HansenDeaN JonesY M GoW E TorresT R ZieglerE LinJames P LewisR L MesserL PittsS D HsuJason Merrell HansenJ C WatahaJ C WatahaJill LewisV V McCloudM ShawY OmataP E LockwoodR L MesserJason Merrell HansenJason Merrell HansenS Moriarty-CraigeDean JonesP J HalveyJason Merrell HansenJ M JohnsonY M GoA SamaliDean JonesJason Merrell HansenM KlassCraig HarrisM CseteY M GoT R ZieglerJ M JohnsonL GuJason Merrell HansenDean JonesS RamachandiranJason Merrell HansenDean JonesJason RichardsonG W MillerJason Merrell HansenJason Merrell HansenH ZhangDean JonesJason Merrell HansenH ZhangDean JonesJason Merrell HansenY M GoDean JonesJason Merrell HansenW H WatsonDean JonesJason Merrell HansenCraig HarrisJason Merrell HansenS G GongM PhilbertCraig HarrisJason Merrell HansenK K HarrisM A PhilbertCraig HarrisJason Merrell HansenE W CarneyCraig Harris
Presentations
Jason Merrell HansenRobin E CharBrandon CroftsCraig Harris
