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Jason Hansen

Associate Professor
Physiology & Developmental Biology

3047 LSB
Provo, UT
84602

(801) 422-2158

Publications

Journal Articles

Mackay AD, Marchant ED, Munk DJ, Watt RK, Hansen JM, Thomson DM, Hancock CR. 2019. Multi-Tissue Analysis of Exercise or Metformin on Doxorubicin-Induced Iron Dysregulation.

Rowley, 4th TJ, Bitner BF, Ray JD, Lathen DR, Smithson AT, Dallon BW, Plowman CJ, Bikman BT, Hansen JM, Dorenkott MR, et al. 2017. Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration. 49:30-41.

Chen T, Moore TM, Ebbert MT, McVey NL, Madsen SR, Hallowell DM, Harris AM, Mackay RP, Char RE, Hancock CR, et al. 2016. Liver kinase B1 inhibits the expression of inflammation-related genes post-contraction in skeletal muscle. Journal of applied physiology. 120(8):876-888.

Harris C, Jilek JL, Sant KE, Pohl J, Reed M, Hansen JM. 2015. Amino acid starvation induced by protease inhibition produces differential alterations in redox status and the thiol proteome in organogenesis-stage rat embryos and visceral yolk sacs. The Journal of nutritional biochemistry. 26(12):1589-98.

Jilek JL, Sant KE, Cho KH, Reed MS, Pohl J, Hansen JM, Harris C. 2015. Ethanol Attenuates Histiotrophic Nutrition Pathways and Alters the Intracellular Redox Environment and Thiol Proteome during Rat Organogenesis. Toxicological Sciences. 147(2):475-89.

Hansen JM, Harris C. 2015. Glutathione during embryonic development. Biochimica et biophysica acta. 1850(8):1527-42.

Easley, 4th CA, Bradner JM, Moser A, Rickman CA, McEachin ZT, Merritt MM, Hansen JM, Caudle WM. 2015. Assessing reproductive toxicity of two environmental toxicants with a novel in vitro human spermatogenic model. Stem cell research. 14(3):347-55.

Downs CA, Kreiner L, Zhao XM, Trac P, Johnson NM, Hansen JM, Brown LA, Helms MN. 2015. Oxidized glutathione (GSSG) inhibits epithelial sodium channel activity in primary alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. 308(9):L943-52.

Hunt WR, Zughaier SM, Guentert DE, Shenep MA, Koval M, McCarty NA, Hansen JM. 2014. Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes. American journal of physiology. Lung cellular and molecular physiology. 306(1):L43-9.

Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free radical biology & medicine. 65:89-101.

Harris CW, Shuster DZ, Roman Gomez R, Sant KE, Pohl J, Hansen JM. 2013. Inhibition of glutathione biosynthesis alters compartmental redox status and the thiol proteome in organogenesis-stage rat conceptuses. Free radical biology & medicine. 63:325-37.

Kathiria AS, Butcher MA, Hansen JM, Theiss AL. 2013. Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis. American journal of physiology. Gastrointestinal and liver physiology. 304(10):G885-96.

Hansen JM, Harris C. 2013. Redox control of teratogenesis. Reproductive toxicology. 35:165-79.

Siore AM, Parker RE, Cuppels C, Thorn N, Hansen JM, Stecenko AA, Brigham KL. 2012. The role of mitochondrial oxidation in endotoxin-induced liver-dependent swine pulmonary edema. Pulmonary pharmacology & therapeutics. 25(5):407-12.

Harris C, Hansen JM. 2012. Nrf2-mediated resistance to oxidant-induced redox disruption in embryos. Birth defects research. Part B, Developmental and reproductive toxicology. 95(3):213-8.

Hansen JM. 2012. In vivo models of developmental toxicology. Methods in molecular biology. 889:7-13.

Harris C, Hansen JM. 2012. Oxidative stress, thiols, and redox profiles. Methods in molecular biology. 889:325-46.

Hansen JM. 2012. Thioredoxin redox status assessment during embryonic development: the redox Western. Methods in molecular biology. 889:305-13.

Roede JR, Hansen JM, Go YM, Jones DP. 2011. Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system. Toxicological sciences. 121(2):368-75.

Imhoff BR, Hansen JM. 2011. Differential redox potential profiles during adipogenesis and osteogenesis. Cellular & molecular biology letters. 16(1):149-61.

Wu J, Hansen JM, Hao L, Taylor RN, Sidell N. 2011. Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species. The Journal of physiology. 589(Pt 4):863-75.

Fischer L, Igoudjil A, Magrané J, Li Y, Hansen JM, Manfredi G, Glass JD. 2011. SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse. Brain. 134(Pt 1):196-209.

Imhoff BR, Hansen JM. 2010. Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation. Cell biology and toxicology. 26(6):541-51.

Imhoff BR, Hansen JM. 2010. Extracellular redox environments regulate adipocyte differentiation. Differentiation. 80(1):31-9.

Imhoff BR, Hansen JM. 2009. Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species. The Biochemical journal. 424(3):491-500.

Tipple TE, Welty SE, Nelin LD, Hansen JM, Rogers L. 2009. Alterations of the thioredoxin system by hyperoxia: implications for alveolar development. American journal of respiratory cell and molecular biology. 41(5):612-9.

Kleinhenz JM, Kleinhenz DJ, You S, Ritzenthaler JD, Hansen JM, Archer DR, Sutliff RL, Hart M. 2009. Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production. American journal of physiology. Heart and circulatory physiology. 297(5):H1647-54.

Lin PW, Myers LE, Ray L, Song SC, Nasr TR, Berardinelli AJ, Kundu K, Murthy N, Hansen JM, Neish AS. 2009. Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free radical biology & medicine. 47(8):1205-11.

Widder JD, Fraccarollo D, Galuppo P, Hansen JM, Jones D, Ertl G, Bauersachs J. 2009. Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of Thioredoxin 2. Hypertension. 54(2):338-44.

Theiss AL, Vijay-Kumar M, Obertone TS, Jones D, Hansen JM, Gewirtz AT, Merlin D, Sitaraman SV. 2009. Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice. Gastroenterology. 137(1):199-208, 208.e1-6.

Gletsu-Miller N, Hansen JM, Jones D, Go YM, Torres WE, Ziegler TR, Lin E. 2009. Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery. Obesity (Silver Spring, Md.). 17(3):439-46.

Lewis JP, Messer RL, Pitts L, Hsu SD, Hansen JM, Wataha JC. 2009. Ni(II) ions dysregulate cytokine secretion from human monocytes. Journal of biomedical materials research. Part B, Applied biomaterials. 88(2):358-65.

Wataha JC, Lewis J, McCloud VV, Shaw M, Omata Y, Lockwood PE, Messer RL, Hansen JM. 2008. Effect of mercury(II) on Nrf2, thioredoxin reductase-1 and thioredoxin-1 in human monocytes. Dental materials. 24(6):765-72.

Hansen JM, Moriarty-Craige S, Jones D. 2007. Nuclear and cytoplasmic peroxiredoxin-1 differentially regulate NF-kappaB activities. Free radical biology & medicine. 43(2):282-8.

Halvey PJ, Hansen JM, Johnson JM, Go YM, Samali A, Jones D. 2007. Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase. Antioxidants & redox signaling. 9(7):807-16.

Hansen JM, Klass M, Harris C, Csete M. 2007. A reducing redox environment promotes C2C12 myogenesis: implications for regeneration in aged muscle. Cell biology international. 31(6):546-53.

Go YM, Ziegler TR, Johnson JM, Gu L, Hansen JM, Jones D. 2007. Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells. Free radical biology & medicine. 42(3):363-70.

Ramachandiran S, Hansen JM, Jones D, Richardson J, Miller GW. 2007. Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicological sciences. 95(1):163-71.

Hansen JM. 2006. Oxidative stress as a mechanism of teratogenesis. Birth defects research. Part C, Embryo today : reviews. 78(4):293-307.

Hansen JM, Zhang H, Jones D. 2006. Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis. Toxicological sciences. 91(2):643-50.

Hansen JM, Zhang H, Jones D. 2006. Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions. Free radical biology & medicine. 40(1):138-45.

Hansen JM, Go YM, Jones D. 2006. Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling. Annual review of pharmacology and toxicology. 46:215-34.

Hansen JM, Watson WH, Jones D. 2004. Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1. Toxicological sciences. 82(1):308-17.

Hansen JM, Gong SG, Philbert M, Harris C. 2002. Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide. Developmental dynamics. 225(2):186-94.

Hansen JM, Harris KK, Philbert MA, Harris C. 2002. Thalidomide modulates nuclear redox status and preferentially depletes glutathione in rabbit limb versus rat limb. The Journal of pharmacology and experimental therapeutics. 300(3):768-76.

Hansen JM, Carney EW, Harris C. 1999. Differential alteration by thalidomide of the glutathione content of rat vs. rabbit conceptuses in vitro. Reproductive toxicology. 13(6):547-54.

Book Chapter

Hansen JM, Plowman CJ, Piorczynski TB. 2017. Developmental toxicity of antiepileptic drugs-- An update. , editor. Comprehensive Toxciology.

Other

Hansen JM, Harris C. 2004. A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway. 1st ed.

Presentations

Hansen JM, Char RE, Crofts B, Harris C. Dysregulation of the redox proteome in teratogenesis: Mediation throught Nrf2 activation. Teratology Society. 2015 .

Hansen JM. Inhibition of valproic acid-induced malformation through Nrf2 activation. Teratology Society Annual Meetings. 2014 .