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Jonathon Hill

Assistant Professor
Physiology & Developmental Biology

Office: LSB 3018
Provo, UT 84602

Biography

Research Interests


I am interested in understanding how genes are regulated during heart formation. The heart forms as a linear tube and then loops around to form the ball-like shape of the adult heart. I am combining bioinformatics and bench biology to study how gene expression is controlled during this process. Understanding the molecular mechanisms underlying heart development will help improve diagnosis and treatment of congenital heart disease.

Education

  • Ph.D., Genetics and Development, Columbia University, 2010
  • M.Phil., Genetics and Development, Columbia University, 2008
  • MS, Molecular Biology, University of Colorado Denver School of Medicine, 2007
  • BS, Microbiology, Brigham Young University, 2005

Experience

Academic - Post-Secondary

  • Assistant Professor, Brigham Young University, 2015-Present
  • Postdoctoral Fellow, University Of Utah, 2010-2015

Honors and Awards

  • Columbia University : Ph.D. Awarded with Distinction

Courses Taught

Winter 2019

  • PDBIO 295R: Introductory Undgrad Research Section 008
  • PDBIO 349R: PDBio Teaching Experience Section 010
  • PDBIO 360: Cell Biology Section 001
  • PDBIO 495R: Adv Undergraduate Research Section 008, 024
  • PDBIO 550R: Advanced Topics in PDBio Section 010
  • PDBIO 570: Responsible Research Conduct Section 001
  • PDBIO 699R: Master's Thesis Section 008
  • PDBIO 799R: Dissertation Section 008

Fall 2018

  • PDBIO 295R: Introductory Undgrad Research Section 008
  • PDBIO 349R: PDBio Teaching Experience Section 009
  • PDBIO 360: Cell Biology Section 001
  • PDBIO 495R: Adv Undergraduate Research Section 008, 022
  • PDBIO 601: Cell & Molecular Physiology Section 001
  • PDBIO 649R: Laboratory Research Section 008
  • PDBIO 799R: Dissertation Section 008

Summer 2018

  • PDBIO 349R: PDBio Teaching Experience Section 003
  • PDBIO 495R: Adv Undgraduate Research Section 008
  • PDBIO 649R: Laboratory Research Section 008

Spring 2018

  • PDBIO 295R: Introductory Undgrad Research Section 008
  • PDBIO 349R: PDBio Teaching Experience Section 010
  • PDBIO 495R: Adv Undgraduate Research Section 008
  • PDBIO 649R: Laboratory Research Section 009

Research Interests

I am interested in understanding how genes are regulated during heart formation. The heart forms as a linear tube and then loops around to form the ball-like shape of the adult heart. I am combining bioinformatics and bench biology to study how gene expression is controlled during this process. Understanding the molecular mechanisms underlying heart development will help improve diagnosis and treatment of congenital heart disease.

Education

  • Ph.D., Genetics and Development , institution ( 2010-01-01 - 2010-12-31 )
  • M.Phil., Genetics and Development , institution ( 2008-01-01 - 2008-12-31 )
  • MS, Molecular Biology , institution ( 2007-01-01 - 2007-12-31 )
  • BS, Microbiology , institution ( 2005-01-01 - 2005-12-31 )

Honors and Awards

  • Ph.D. Awarded with Distinction

Professional Citizenship

  • Reviewer, Ad Hoc Reviewer, Pediatric Intensive Care, 2020-02-01 - 2020-02-28 - Present
  • Reviewer, Ad Hoc Reviewer, Advanced Science, 2019-11-01 - 2019-11-30 - Present
  • Reviewer, Ad Hoc Reviewer, Science Advances, 2019-08-01 - 2019-08-31 - Present
  • Other, Ivy Hall Private School, 2018-04-01 - 2018-04-30 - Present
  • Officer (specify in Other), Provo City, 2018-04-01 - 2018-04-30 - Present
  • Reviewer, Ad Hoc Reviewer, Developmental Dynamics, 2016-11-01 - 2016-11-30 - Present
  • Other, Sunset Elementary Shool, 2016-04-01 - 2016-04-30 - Present
  • Reviewer, Ad Hoc Reviewer, Developmental Biology, 2016-03-01 - 2016-03-31 - Present
  • Reviewer, Ad Hoc Reviewer, BMC Bioinformatics, 2015-11-01 - 2015-11-30 - Present
  • Grant Proposal Reviewer, External, Polish National Science Centre, 2018-10-01 - 2018-10-31 - 2018-10-01 - 2018-10-31
  • Other, American Journal Experts, 2015-06-01 - 2015-06-30 - 2018-06-01 - 2018-06-30

Courses Taught

2020

  • PDBIO 495R: Section 008
  • PDBIO 550R: Section 009
  • PDBIO 360 : Section 001
  • PDBIO 799R: Section 007
  • PDBIO 295R: Section 007
  • PDBIO 495R: Section 008
  • PDBIO 495R: Section 008
  • PDBIO 360 : Section 001
  • PDBIO 495R: Section 008
  • PDBIO 360 : Section 001
  • PDBIO 799R: Section 008
  • PDBIO 295R: Section 008
  • PDBIO 649R: Section 008
  • PDBIO 349R: Section 010
  • PDBIO 570 : Section 001

2019

  • PDBIO 495R: Section 008
  • PDBIO 360 : Section 001
  • PDBIO 799R: Section 008
  • PDBIO 295R: Section 008
  • PDBIO 349R: Section 009
  • PDBIO 495R: Section 008
  • PDBIO 295R: Section 008
  • PDBIO 495R: Section 008
  • PDBIO 295R: Section 008
  • PDBIO 649R: Section 009
  • PDBIO 495R: Section 008
  • PDBIO 495R: Section 024
  • PDBIO 550R: Section 010
  • PDBIO 360 : Section 001
  • PDBIO 799R: Section 008
  • PDBIO 295R: Section 008
  • PDBIO 699R: Section 008
  • PDBIO 349R: Section 010
  • PDBIO 570 : Section 001

2018

  • PDBIO 495R: Section 008
  • PDBIO 495R: Section 022
  • PDBIO 601 : Section 001
  • PDBIO 360 : Section 001
  • PDBIO 799R: Section 008
  • PDBIO 295R: Section 008
  • PDBIO 649R: Section 008
  • PDBIO 349R: Section 009
  • PDBIO 495R: Section 008
  • PDBIO 649R: Section 008
  • PDBIO 349R: Section 003
  • PDBIO 495R: Section 008
  • PDBIO 295R: Section 008
  • PDBIO 649R: Section 009
  • PDBIO 349R: Section 010
  • PDBIO 495R: Section 008
  • PDBIO 550R: Section 011
  • PDBIO 360 : Section 001
  • PDBIO 295R: Section 008
  • PDBIO 699R: Section 008
  • PDBIO 349R: Section 011
  • PDBIO 570 : Section 001

2017

  • PDBIO 495R: Section 009
  • PDBIO 601 : Section 001
  • PDBIO 360 : Section 001
  • PDBIO 360 : Section 002
  • PDBIO 295R: Section 009
  • PDBIO 649R: Section 009
  • PDBIO 699R: Section 009
  • PDBIO 349R: Section 024
  • PDBIO 495R: Section 9
  • PDBIO 495R: Section 009
  • PDBIO 360 : Section 002
  • PDBIO 649R: Section 009
  • PDBIO 349R: Section 11
  • PDBIO 494R: Section 9

2016

  • PDBIO 495R: Section 009
  • PDBIO 601 : Section 001
  • PDBIO 360 : Section 002
  • PDBIO 494R: Section 9
  • PDBIO 495R: Section 009
  • PDBIO 494R: Section 9
  • PDBIO 494R: Section 9
  • PDBIO 495R: Section 009
  • PDBIO 360 : Section 002
  • PDBIO 494R: Section 009

2015

  • PDBIO 495R: Section 4
  • PDBIO 494R: Section 004

Publications

  • McGuire KL, Smit P, Ess DH, Hill JT, Harrison RG, Busath DD. January (1st Quarter/Winter) 5, 2021. Mechanism and Kinetics of Copper Complexes Binding to the Influenza A M2 S31N and S31N/G34E Channels. 1st ed.
  • McGuire KL, Hill JT, Busath DD. November 3, 2020. Increased Dissociation of Adamantanamines in Influenza A M2 S31N with Partial Block by Rimantadine. 9th ed.
  • Chen T, Hill JT, Moore TM, ECK C, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, et alApril (2nd Quarter/Spring) 24, 2020. Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. 8th ed.
  • Domyan ET, Hardy J, Wright T, Frazer C, Daniels J, Kirkpatrick J, Hill JT. September 1, 2019. SOX10 regulates multiple genes to direct eumelanin versus pheomelanin production in domestic rock pigeon. 5th ed.
  • Fox J, Evans AT, Blomfield MP, Livingstone SK, Tenney SR, Webster JB, Perry K, Hill JT, Bikman BT, MDH H. July (3rd Quarter/Summer) 1, 2019. Resistance mechanisms and cross-resistance for a pyridine-pyrimidine amide inhibitor of microtubule polymerization. 13th ed.
  • Fox JC, Evans AT, Blomfield MP, Livingstone SK, Tenney SR, Webster JB, Perry K, Hill JT, Bikman BT, Hansen MD. July (3rd Quarter/Summer) 1, 2019. Resistance mechanisms and cross-resistance for a pyridine-pyrimidine amide inhibitor of microtubule polymerization. 13th ed.
  • Hill JT. January (1st Quarter/Winter), 2019. Identifying toxicant-interacting genes using forward-genetic screening in zebrafish. Jason Hansen, Louise Winn, editors. New York, NY: Springer.
  • Speirs MM, Swensen AC, Chan TY, Jones PM, Holman JC, Harris MB, Maschek JA, Cox JE, Carson RH, Hill JT, et alJanuary (1st Quarter/Winter) 11, 2019. Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift. Orchard Park, New York: Impact Journals.
  • Johnson SP, Yates JD, Frederich ZB, Hill JT. December 1, 2018. ZeMo: An Open Source Water Quality Monitoring System for Aquaria. 6th ed.
  • Hill JT, Demarest B, Gorsi B, Smith M, Yost HJ. October (4th Quarter/Autumn), 2017. Heart morphogenesis gene regulatory networks revealed by temporal expression analysis. 19th ed.
  • Karanth S, Zinkhan EK, Hill JT, Yost HJ, Schlegel A. June 21, 2016. FOXN3 Regulates Hepatic Glucose Utilization. 12th ed.
  • Ray JD, Kener KB, Bitner BF, Wright BJ, Ballard MB, Barrett EJ, Hill JT, Moss LG, Tessem JS. June 1, 2016. Nkx61-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos. 12th ed.
  • Hill JT, Demarest BL, Bisgrove BW, Su YC, Smith M, Yost HJ. December 1, 2014. Poly peak parser: Method and software for identification of unknown indels using sanger sequencing of polymerase chain reaction products. 12th ed.
  • Sarkar AA, Nuwayhid SJ, Maynard T, Ghandchi F, Hill JT, Lamantia AS, Zohn IE. August 15, 2014. Hectd1 is required for development of the junctional zone of the placenta. 2nd ed.
  • Hill JT, Demarest BL, Bisgrove BW, Gorsi B, Su YC, Yost HJ. April (2nd Quarter/Spring) 1, 2013. MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq. 4th ed.
  • Maguire CT, Demarest BL, Hill JT, Palmer JD, Brothman AR, Yost HJ, Condic ML. January (1st Quarter/Winter) 1, 2013. Genome-wide analysis reveals the unique stem cell identity of human amniocytes. 1st ed.
  • Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L. January (1st Quarter/Winter) 1, 2012. Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. 12th ed.
  • Hill JT, Anderson KR, Mastracci TL, Kaestner KH, Sussel L. February 25, 2011. Novel computational analysis of protein binding array data identifies direct targets of Nkx22 in the pancreas.
  • Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L. February 1, 2010. Nkx22 activates the ghrelin promoter in pancreatic islet cells. 2nd ed.
  • Hill JT, Mastracci TL, Vinton C, Doyle ML, Anderson KR, Loomis ZL, Schrunk JM, Minic AD, Prabakar KR, Pugliese A, et alOctober (4th Quarter/Autumn) 9, 2009. Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. 1-3rd ed.

Presentations

  • Miller AK, Knowles A, Hill JT, Pickett BE, Nielsen B. Gene expression changes in plant inoculated with halophilic bacteria and grown in salty soil. 2020 Annual ASM Intermountain Branch Meeting. December, 2020.
  • Yates JD, Russell C, Yost HJ, Hill JT. Society For Developmental Biology 2020. July, 2020.
  • Hill JT. A CRISPR/Cas9 Tissue Specific Forward Genetic Screening Method in Danio rerio. International Zebrafish Society SCZI Meeting. January, 2019.
  • Hill JT. Enzymatic Generation of CRISPR Libraries. B2B Consortium Meeting. October, 2018.
  • Hill JT. High Throughput Promoter Analysis. B2B Consortium Meeting. October, 2018.
  • Cheung E, Chen T, Hill JT, Thomson DM. Skeletal muscle gene expression in high fat diet-fed LKB1 knockout mice. Experimental Biology. April, 2018.
  • Hill JT. Time-course Analysis of Heart Looping. NHLBI B2B Consortium Meeting . December, 2016.
  • Hill JT. Using Genetic and Genomic Techniques in Zebrafish to Elucidate Heart Development. Seminar Series. March, 2016.
Jonathon Hill