Julianne Grose

Research Interests

Our lab focuses on two discrete research interests. The first is cellular metabolism. Cells have evolved complex mechanisms that allow them to sense their metabolic status and regulate cellular responses appropriately. A dysfunction in these regulatory processes has been shown to be involved in a variety of diseases including diabetes and cancer. Our lab is interested in the regulation of metabolism in response to the availability of nutrients and other factors affecting growth. We use model organisms, such as Saccaromyces cerevisiae (baker’s yeast), to study key pathways involved in metabolic regulation. Proteins and pathways are often conserved and thus our findings may aid in understanding metabolic regulation in other organisms, including humans. Our lab focuses on the study of PAS kinase, a highly conserved sensory protein kinase that is involved in the regulation of glucose metabolism in both yeast and mammals. The PAS kinase protein has both a sensory and a regulatory domain. The sensory component consists of a PAS domain that may bind small molecule effecters. The PAS domain regulates an attached serine/threonine protein kinase that then modifies other proteins in order to regulate cellular processes in response to certain stimuli. Our goal is to further characterize the role PAS kinase plays in metabolic regulation by identifying specific mechanisms involved in its activation and function.

The second area of interest are Bacterial Hosts And the Phages that infect them (BHAP). Bacteriophages (phages) are viruses that infect bacteria, the most abundant cellular life on the planet. Due to their ability to transfer genetic material and/or kill their hosts, bacteriophages are a major driving force in bacterial evolution. They are incredibly understudied meaning that we regularly isolate and sequence bacteriophages that have no BLAST hits when analyzing their DNA or encoded proteins. Therefore they represent a reservoir of untapped biological resources. In addition, they can provide treatments to many bacterial diseases from phytopathogens to animal and human pathogens.

Honors and Awards

• Alcuin Fellowship, BYU Honors Program (2018 - 2019)
• C. Joseph Rowberry Teaching and Learning Faculty Fellowship, Brigham Young University (2018 - 2019)
• Maesar Excellence in Teaching Award , Brigham Young University (2017 - 2018)
• First place award -NSF Community College Innovation Challenge (2017), NSF (2017 - 2017)
• Faculty Womens Scholarship Award, Faculty Womens Association (2016 - 2017)
• Technology Transfer Ward, BYU Technology Transfer Office (2016 - 2016)
• Gold medal, IGEM (2011)
• American Society for Microbiology Early-Career Faculty Travel Award, American Society for Microbiology (2009 - 2009)
• Ruth L. Kirschstein National Research Service Award Individual Fellowship, National Institute of Health (2006 - 2006)
• Multidisiplinary Cancer Training Fellow, National Institute of Health (2004 - 2006)

Memberships

• American Heart Association (2012 - Present)
• Science Education Alliance (SEA) (2010 - Present)

Professional Citizenship

• Conference-Related Role, 2013 Analytical Genetics Meeting

Courses Taught

Show Previous Years

Publications

Jenny A. Pape Colleen R. Newey Haley R. Burrell Audrey Workman Katelyn Perry Benjamin T. Bikman Laura C. Bridgewater Julianne House Grose D DeMille J A Pape Benjamin Thomas Bikman M Ghassemian Julianne House Grose Jordan Alexander Berg B D Merrill Donald Philip Breakwell Sandra Hope Julianne House Grose R Sharma Jordan Alexander Berg N J Beatty M C Choi A E Cowger Cozzens BJR S G Duncan C P Fajardo H P Ferguson T Galbraith J A Herring T R Hoj J L Durrant J R Hyde G L Jensen S Y Ke S Killpack J L Kruger Lawrence EEK I O Nwosu T C Tam D W Thompson J A Tueller Ward MEH C J Webb M E Wood E L Yeates D A Baltrus Donald Philip Breakwell Sandra Hope Julianne House Grose B D Merrill C P Fajardo J A Hilton A M Payne A T Ward J K Walker A Dhalai C Imahara J Mangohig J Monk C Pascacio P Rai A Salisbury K Velez T J Bloomfield B Buhler S G Duncan D A Fuhriman J George K Graves K Heaton H L Hill M Kim B K Knabe D B Ririe S L Rogers C Stamereilers M B Stephenson B K Usher C S Ward J M Withers C K Wright Donald Philip Breakwell Julianne House Grose Sandra Hope P K Tsourkas D G Yost C Chang L LeBlanc E Cassin C Peterman P Rai A Salisbury N Barroga R Cisneros J Fersini J Juste J Ines G Leyva D Macalinao S Muscelli G S Reyes H Rhoden R Tan E Torres K Tran G Uriarte-Valle C Wallace S Wong K Ayala-Pineda V Cadiz T Jeanite S Nhan Julianne House Grose C Strong P S Amy P K Tsourkas C. Stamereilers C. P. Fajardo J. K. Walker K. N. Mendez E. Castro-Nallar Julianne House Grose Julianne House Grose Sandra Hope P. K. Tsourkas D K Arens T S Brady J L Carter J A Pape D M Robinson K A Russell L A Staley J M Stettler O B Tateoka M H Townsend K V Whitley T M Wienclaw T L Williamson Steven M Johnson Julianne House Grose S D Willis D C Stieg K L Ong R Shah A K Strich Julianne House Grose K F Cooper J K Walker B D Merrill Jordan Alexander Berg A Dhalai D W Dingman C P Fajardo K Graves H L Hill J A Hilton C Imahara B K Knabe J Mangohig J Monk H Mun A M Payne A Salisbury C Stamereilers K Velez A T Ward Donald Philip Breakwell Julianne House Grose Sandra Hope P K Tsourkas D C Stieg S D Willis V Ganesan K L Ong J Scuorzo M Song Julianne House Grose R Strich K F Cooper I. N. D. Esplin J. A. Berg R. Sharma R. C. Allen D. K. Arens C. R. Ashcroft J Bairett M. Bickmore T. J. Bloomfield T. S. Brady R. N. Bybee J. L. Carter M. C. Choi S. Duncan C. P. Fajardo B. B. Foy D. A. Fuhriman P. D. Gibby S. E. Grossarth K. Harbaugh N. Harris J. A. Hilton E. Hurst Ingersoll K. Hyde C. M. Jacobson B. D. James T. M. Jarvis D. Jaen-Anieves G. L. Jensen B. K. Knabe J. L. Kruger B. D. Merrill J. A. Pape A. M. Payne Anderson D. E. Payne M. D. Peck S. V. Pollock M. J. Putnam E. K. Ransom D. B. Ririe D. M. Robinson S. L. Rogers K. A. Russell J. E. Schoenhals C. A. Shurtleff A. R. Simister H. G. Smith M. B. Stephenson L. A. Staley J. M. Stettler M. L. Stratton O. B. Tateoka P. J. Tatlow A. S. Taylor S. E. Thompson M. H. Townsend T. L. Thurgood B. K. Usher K. V. Whitley A T Ward M. E. H. Ward C. J. Webb T. M. Wienclaw T. L. Williamson M. J. Wells C. K. Wright Donald Philip Breakwell Sandra Hope Julianne House Grose Sandra Hope David I. Hanauer Mark J. Graham SEA PHAGES Julianne House Grose Donald Philip Breakwell Laura Betancur Aiyana Bobrownicki Steven G. Cresawn Rebecca A. Garlena Deborah Jacobs-Sera Nancy Kaufmann H. Pope Welkin Daniel A. Russell Viknesh Sivanathan David J. Asai Graham F. Hatfull R. M. Dedrick D. Jacobs-Sera C. A. Bustamante R. A. Garlena T. N. Mavrich W. H. Pope J. C. Reyes D. A. Russell T. Adair R. Alvey J. A. Bonilla J. S. Bricker B. R. Brown D. Byrnes S. G. Cresawn W. B. Davis L. A. Dickson N. P. Edgington A. M. Findley U. Golebiewska Julianne House Grose C. F. Hayes L. E. Hughes K. W. Hutchison S. Isern A. A. Johnson M. A. Kenna K. K. Klyczek C. M. Mageeney S. F. Michael S. D. Molloy M. T. Montgomery J. Neitzel S. T. Page M. C. Pizzorno M. K. Poxleitner C. A. Rinehart C. J. Robinson M. R. Rubin J. N. Teyim E. Vazquez V. C. Ware J. Washington G. F. Hatfull Julianne House Grose Sherwood Casjens Bryan D Merrill Andrew N Ward Julianne House Grose Sandra Hope Jordan A. Berg Bryan D. Merrill J. T. Crockett JT Kyle P. Esplin M. R. Evans Karley E. Heaton Jordan A. Hilton Jonathan R. Hyde Marlee S. McBride Jordan T. Schouten Austin R. Simister Trevor L. Thurgood Andrew T. Ward Donald Philip Breakwell Sandra Hope Julianne House Grose Julianne House Grose Kelsey Langston X Wang Shayne Squires SB Mustafi Whitney Hayes Jonathan Neubert SK Fischer M Fasano GM Saunders Q Dia E Christians ED Lewandowski P Ping Ivor J Benjamin W H Pope C A Bowman D A Russell D Jacobs-Sera D J Asai S G Cresawn W R Jacobs R W Hendrix J G Lawrence G F Hatfull Sandra Hope Julianne House Grose Donald Philip Breakwell Bryan D. Merrill Jordan A. Berg Andrew T. Ward Kiel A Graves Jordan A. Hilton Brandon N. Wake Julianne House Grose Julianne House Grose Donald Philip Breakwell Sandra Hope Desiree DeMille Bryan D Badal J Brady Evans Andrew D Mathis Joe F Anderson Julianne House Grose Julianne House Grose David M Belnap Jordan D Jensen Andrew D Mathis John T Prince Bryan D Merrill Sandra Hope Donald Philip Breakwell Julianne House Grose Gavin Scott Jensen Sandra Hope Donald Philip Breakwell Julianne House Grose Sherwood R Casjens Bryan D Merrill Julianne House Grose Donald Philip Breakwell Sandra Hope Desiree DeMille Benjamin Thomas Bikman Andrew D. Mathis John T Prince Jordan T. Mackay Steven W. Sowa Tacie D. Hall Julianne House Grose Julianne House Grose Jordan D. Jensen Bryan D Merrill Joshua Fisher Sandra Hope Donald Philip Breakwell Desiree DeMille Julianne House Grose Donald Philip Breakwell E. Zane Barrus Alex B. Benedict Alicia K. Brighton Joshua N.B. Fisher Adam V. Gardner Brittany J. Kartchner Kara C. Ladle Bryce L. Lunt Bryan D. Merrill John D. Morrell Sandra Hope Julianne House Grose Michael A. Sheflo Adam V. Gardner Bryan D. Merrill Joshua NB. Fisher Bryce L. Lunt Donald Philip Breakwell Julianne House Grose Sandra Hope Mustafi S Banerjee Julianne House Grose Huali Zhang Gregg W. Pratt J. Sadoshima Elisabeth Christians Ivor Benjamin Kyle C Smith Eduardo Castro-Nallar Joshua N.B. Fisher Donald Philip Breakwell Julianne House Grose Sandra Hope Julius Adebayo Taylor Southwick Vasu Chetty Enoch Yeung Ye Yuan Jorge Goncalves Julianne House Grose John T Prince Gyu-Bart Stan Sean C Warnick Graham Hatfull Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) program KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) Mycobacterial Genetics Course Phage Hunters Integrating Research and Education (PHIRE) program Julianne House Grose Sandra Hope Donald Philip Breakwell B J Earley J M Engle K C Smith B L Lunt J N.B. Fisher D E Payne II Donald Philip Breakwell Sandra Hope Julianne House Grose Julianne House Grose H. Fried-Petersen T. L. Adair K. R. Anders S. B. Aley S. A. Bratsch K. L. Clase J. M. Coleman L. H. Debro S. Dellis Y. Fang S. Findeis B. C. Gibbon U. P. Golebiewska W. H. Grillo A. Hester G. P. Hollowell S. Kearney J. Kelly K. Klyczek G. Kuleck J. A. Londono K. Mogen D. L. Monti C. Murdock R. Ovalle S. Pfeif M. C. Pizzorno M. Poxleitner D. Reyes J. L. Rickus G. Rosas-Acosta P. Schneider E. Stowe-Evans J. Stukey M. A. Taylor M. Tollis C. K. Wong H. Wu A. M. Zimmerman S. G. Cresawn E. Lee C. D. Shaffer L. P. Barker K. W. Bradley R. Khaja M. F. Lewis T. C. Jordan D. A. Russell W. H. Pope D. Jacobs-Sera R. W. and Hendrix G. F. Hatfull Julianne House Grose Julianne House Grose Jared Rutter

Presentations