Our lab focuses on two discrete research interests. The first is cellular metabolism. Cells have evolved complex mechanisms that allow them to sense their metabolic status and regulate cellular responses appropriately. A dysfunction in these regulatory processes has been shown to be involved in a variety of diseases including diabetes and cancer. Our lab is interested in the regulation of metabolism in response to the availability of nutrients and other factors affecting growth. We use model organisms, such as Saccaromyces cerevisiae (baker’s yeast), to study key pathways involved in metabolic regulation. Proteins and pathways are often conserved and thus our findings may aid in understanding metabolic regulation in other organisms, including humans. Our lab focuses on the study of PAS kinase, a highly conserved sensory protein kinase that is involved in the regulation of glucose metabolism in both yeast and mammals. The PAS kinase protein has both a sensory and a regulatory domain. The sensory component consists of a PAS domain that may bind small molecule effecters. The PAS domain regulates an attached serine/threonine protein kinase that then modifies other proteins in order to regulate cellular processes in response to certain stimuli. Our goal is to further characterize the role PAS kinase plays in metabolic regulation by identifying specific mechanisms involved in its activation and function.
The second area of interest are Bacterial Hosts And the Phages that infect them (BHAP). Bacteriophages (phages) are viruses that infect bacteria, the most abundant cellular life on the planet. Due to their ability to transfer genetic material and/or kill their hosts, bacteriophages are a major driving force in bacterial evolution. They are incredibly understudied meaning that we regularly isolate and sequence bacteriophages that have no BLAST hits when analyzing their DNA or encoded proteins. Therefore they represent a reservoir of untapped biological resources. In addition, they can provide treatments to many bacterial diseases from phytopathogens to animal and human pathogens.
Education
Ph.D., Biology , University of Utah (2003)
BS, Chemistry , Mathematics, University of Utah (1996)
Honors and Awards
Alcuin Fellowship, BYU Honors Program
(2018 - 2019)
C. Joseph Rowberry Teaching and Learning Faculty Fellowship, Brigham Young University
(2018 - 2019)
Maesar Excellence in Teaching Award , Brigham Young University
(2017 - 2018)
First place award -NSF Community College Innovation Challenge (2017), NSF
(2017 - 2017)
Faculty Womens Scholarship Award, Faculty Womens Association
(2016 - 2017)
Technology Transfer Ward, BYU Technology Transfer Office
(2016 - 2016)
Gold medal, IGEM
(2011 - 2011)
American Society for Microbiology Early-Career Faculty Travel Award, American Society for Microbiology
(2009 - 2009)
Ruth L. Kirschstein National Research Service Award Individual Fellowship, National Institute of Health
(2006 - 2006)
Multidisiplinary Cancer Training Fellow, National Institute of Health
(2004 - 2006)
Jenny A. PapeColleen R. NeweyHaley R. BurrellAudrey WorkmanKatelyn PerryBenjamin T. BikmanLaura C. BridgewaterJulianne House GroseD DeMilleJ A PapeBenjamin Thomas BikmanM GhassemianJulianne House GroseJordan Alexander BergB D MerrillDonald Philip BreakwellSandra HopeJulianne House GroseR SharmaJordan Alexander BergN J BeattyM C ChoiA E CowgerCozzens BJRS G DuncanC P FajardoH P FergusonT GalbraithJ A HerringT R HojJ L DurrantJ R HydeG L JensenS Y KeS KillpackJ L KrugerLawrence EEKI O NwosuT C TamD W ThompsonJ A TuellerWard MEHC J WebbM E WoodE L YeatesD A BaltrusDonald Philip BreakwellSandra HopeJulianne House GroseB D MerrillC P FajardoJ A HiltonA M PayneA T WardJ K WalkerA DhalaiC ImaharaJ MangohigJ MonkC PascacioP RaiA SalisburyK VelezT J BloomfieldB BuhlerS G DuncanD A FuhrimanJ GeorgeK GravesK HeatonH L HillM KimB K KnabeD B RirieS L RogersC StamereilersM B StephensonB K UsherC S WardJ M WithersC K WrightDonald Philip BreakwellJulianne House GroseSandra HopeP K TsourkasD G YostC ChangL LeBlancE CassinC PetermanP RaiA SalisburyN BarrogaR CisnerosJ FersiniJ JusteJ InesG LeyvaD MacalinaoS MuscelliG S ReyesH RhodenR TanE TorresK TranG Uriarte-ValleC WallaceS WongK Ayala-PinedaV CadizT JeaniteS NhanJulianne House GroseC StrongP S AmyP K TsourkasC. StamereilersC. P. FajardoJ. K. WalkerK. N. MendezE. Castro-NallarJulianne House GroseJulianne House GroseSandra HopeP. K. TsourkasD K ArensT S BradyJ L CarterJ A PapeD M RobinsonK A RussellL A StaleyJ M StettlerO B TateokaM H TownsendK V WhitleyT M WienclawT L WilliamsonSteven M JohnsonJulianne House GroseS D WillisD C StiegK L OngR ShahA K StrichJulianne House GroseK F CooperJ K WalkerB D MerrillJordan Alexander BergA DhalaiD W DingmanC P FajardoK GravesH L HillJ A HiltonC ImaharaB K KnabeJ MangohigJ MonkH MunA M PayneA SalisburyC StamereilersK VelezA T WardDonald Philip BreakwellJulianne House GroseSandra HopeP K TsourkasD C StiegS D WillisV GanesanK L OngJ ScuorzoM SongJulianne House GroseR StrichK F CooperSandra HopeDavid I. HanauerMark J. GrahamSEA PHAGESJulianne House GroseDonald Philip BreakwellLaura BetancurAiyana BobrownickiSteven G. CresawnRebecca A. GarlenaDeborah Jacobs-SeraNancy KaufmannH. Pope WelkinDaniel A. RussellViknesh SivanathanDavid J. AsaiGraham F. HatfullI. N. D. EsplinJ. A. BergR. SharmaR. C. AllenD. K. ArensC. R. AshcroftJ BairettM. BickmoreT. J. BloomfieldT. S. BradyR. N. BybeeJ. L. CarterM. C. ChoiS. DuncanC. P. FajardoB. B. FoyD. A. FuhrimanP. D. GibbyS. E. GrossarthK. HarbaughN. HarrisJ. A. HiltonE. HurstIngersoll K. HydeC. M. JacobsonB. D. JamesT. M. JarvisD. Jaen-AnievesG. L. JensenB. K. KnabeJ. L. KrugerB. D. MerrillJ. A. PapeA. M. Payne AndersonD. E. PayneM. D. PeckS. V. PollockM. J. PutnamE. K. RansomD. B. RirieD. M. RobinsonS. L. RogersK. A. RussellJ. E. SchoenhalsC. A. ShurtleffA. R. SimisterH. G. SmithM. B. StephensonL. A. StaleyJ. M. StettlerM. L. StrattonO. B. TateokaP. J. TatlowA. S. TaylorS. E. ThompsonM. H. TownsendT. L. ThurgoodB. K. UsherK. V. WhitleyA T WardM. E. H. WardC. J. WebbT. M. WienclawT. L. WilliamsonM. J. WellsC. K. WrightDonald Philip BreakwellSandra HopeJulianne House GroseR. M. DedrickD. Jacobs-SeraC. A. BustamanteR. A. GarlenaT. N. MavrichW. H. PopeJ. C. ReyesD. A. RussellT. AdairR. AlveyJ. A. BonillaJ. S. BrickerB. R. BrownD. ByrnesS. G. CresawnW. B. DavisL. A. DicksonN. P. EdgingtonA. M. FindleyU. GolebiewskaJulianne House GroseC. F. HayesL. E. HughesK. W. HutchisonS. IsernA. A. JohnsonM. A. KennaK. K. KlyczekC. M. MageeneyS. F. MichaelS. D. MolloyM. T. MontgomeryJ. NeitzelS. T. PageM. C. PizzornoM. K. PoxleitnerC. A. RinehartC. J. RobinsonM. R. RubinJ. N. TeyimE. VazquezV. C. WareJ. WashingtonG. F. HatfullJulianne House GroseSherwood CasjensBryan D MerrillAndrew N WardJulianne House GroseSandra HopeJordan A. BergBryan D. MerrillJ. T. Crockett JTKyle P. EsplinM. R. EvansKarley E. HeatonJordan A. HiltonJonathan R. HydeMarlee S. McBrideJordan T. SchoutenAustin R. SimisterTrevor L. ThurgoodAndrew T. WardDonald Philip BreakwellSandra HopeJulianne House GroseJulianne House GroseKelsey LangstonX WangShayne SquiresSB MustafiWhitney HayesJonathan NeubertSK Fischer M FasanoGM SaundersQ DiaE ChristiansED Lewandowski P PingIvor J BenjaminW H PopeC A BowmanD A RussellD Jacobs-SeraD J AsaiS G CresawnW R JacobsR W HendrixJ G LawrenceG F HatfullSandra HopeJulianne House GroseDonald Philip BreakwellBryan D. MerrillJordan A. BergAndrew T. Ward Kiel A GravesJordan A. HiltonBrandon N. WakeJulianne House GroseJulianne House GroseDonald Philip BreakwellSandra HopeDesiree DeMilleBryan D BadalJ Brady EvansAndrew D MathisJoe F AndersonJulianne House GroseJulianne House GroseDavid M BelnapJordan D JensenAndrew D MathisJohn T PrinceBryan D MerrillSandra HopeDonald Philip BreakwellJulianne House GroseGavin Scott JensenSandra HopeDonald Philip BreakwellJulianne House GroseSherwood R CasjensBryan D MerrillJulianne House GroseDonald Philip BreakwellSandra HopeDesiree DeMilleBenjamin Thomas BikmanAndrew D. MathisJohn T PrinceJordan T. MackaySteven W. SowaTacie D. HallJulianne House GroseJulianne House GroseJordan D. JensenBryan D MerrillJoshua FisherSandra HopeDonald Philip BreakwellDesiree DeMilleJulianne House GroseDonald Philip BreakwellE. Zane BarrusAlex B. BenedictAlicia K. BrightonJoshua N.B. FisherAdam V. GardnerBrittany J. KartchnerKara C. LadleBryce L. LuntBryan D. MerrillJohn D. MorrellSandra HopeJulianne House GroseMichael A. ShefloAdam V. GardnerBryan D. MerrillJoshua NB. FisherBryce L. LuntDonald Philip BreakwellJulianne House GroseSandra HopeMustafi S BanerjeeJulianne House GroseHuali ZhangGregg W. PrattJ. SadoshimaElisabeth ChristiansIvor BenjaminKyle C SmithEduardo Castro-NallarJoshua N.B. FisherDonald Philip BreakwellJulianne House GroseSandra HopeJulius AdebayoTaylor SouthwickVasu ChettyEnoch YeungYe YuanJorge GoncalvesJulianne House GroseJohn T PrinceGyu-Bart StanSean C WarnickGraham HatfullScience Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) programKwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) Mycobacterial Genetics CoursePhage Hunters Integrating Research and Education (PHIRE) programJulianne House GroseSandra HopeDonald Philip BreakwellB J EarleyJ M EngleK C SmithB L LuntJ N.B. FisherD E Payne IIDonald Philip BreakwellSandra HopeJulianne House GroseJulianne House GroseH. Fried-PetersenT. L. AdairK. R. AndersS. B. AleyS. A. BratschK. L. ClaseJ. M. ColemanL. H. DebroS. DellisY. FangS. FindeisB. C. GibbonU. P. GolebiewskaW. H. GrilloA. HesterG. P. HollowellS. KearneyJ. KellyK. KlyczekG. KuleckJ. A. LondonoK. MogenD. L. MontiC. MurdockR. OvalleS. PfeifM. C. PizzornoM. PoxleitnerD. ReyesJ. L. RickusG. Rosas-AcostaP. SchneiderE. Stowe-EvansJ. StukeyM. A. TaylorM. TollisC. K. WongH. WuA. M. ZimmermanS. G. CresawnE. LeeC. D. ShafferL. P. BarkerK. W. BradleyR. KhajaM. F. LewisT. C. JordanD. A. RussellW. H. PopeD. Jacobs-SeraR. W. and HendrixG. F. HatfullJulianne House GroseJulianne House GroseJared Rutter
Presentations
C FajardoS MeredithC RollCJoel Shelby GriffittsSandra HopeJulianne House GroseDonald Philip Breakwell
Jeralyn FransonJoseph WhiteKai Li OngNidhi ChoksiAlistair HiltonAndrew ReesJared ResolmeJeffrey ZhaoRachel SeveyKyle OlsenJulianne House GroseLaura Clarke Bridgewater
Jeralyn FransonRachel SeveyJeffrey ZhaoJoseph WhiteAlistair HiltonAndrew ReesKai Li OngNidhi ChoksiJulianne House GroseLaura Clarke Bridgewater
Jeffrey ZhaoSavannah GrossarthJulianne House GroseLaura Clarke Bridgewater
Joseph WhiteJeralyn FransonAndrew ReesAlistair HiltonKai Li OngNidhi ChoksiJared ResolmeJeffrey ZhaoJulianne House GroseLaura Clarke Bridgewater
Julianne House GroseBenjamin Thomas BikmanDesiree DemilleJenny Pattison
Julianne House GroseBenjamin Thomas BikmanDesiree DeMille
Julianne House GroseJenny PattinsonDesiree DeMilleBenjamin Thomas Bikman
Vasu ChettyJulius AdebayoAndrew MathisDesiree DemilleStewart MorleyTamil AnthonymuthuYe YuanJorge GoncalvesJulianne House GroseJohn T PrinceGuy-Bart StanSean C Warnick
Andrew MathisTamil Selvan AnthonymuthuStewart MorleyTaylor SouthwickDesiree DeMilleJulianne House GroseJulius AdebayoSean C WarnickJohn T Prince
Julianne House GroseDavid Lee KooymanMathew BiggsChet ChamberlainMackay MerrillDevin SabinMark SabinJulie RobertsLawrence WilliamsAddison AlleyJulius Adebayo
Julianne House GroseDavid Lee KooymanMathew BiggsChet ChamberlainMackay MerrillDevin SabinMark SabinJulie RobertsLawrence WilliamsAddison AlleyJulius Adebayo
Julianne House GroseDavid Lee KooymanMathew BiggsChet ChamberlainMackay MerrillDevin SabinMark SabinJulie RobertsLawrence WilliamsAddison AlleyJulius Adebayo
Julianne House Grose
Julianne House GroseDavid Lee KooymanMathew BiggsChet ChamberlainMackay MerrillDevin SabinMark SabinJulie RobertsLawrence WilliamsAddison AlleyJulius Adebayo
Alicia K. BrightonJoshua FisherBryce L. LuntMary Ann TaylorKyle C. SmithE. Zane Barrus Breeanna BakerKylie M. ChapmanEmily A. DrakeKyle R. JacksonBrittany J. KartchnerChristopher D. KiserJonathan T. KiserJordan KitchenWade S. McDanielWilson R. OrmsbyMarshall G. SheideRyan P. SteckKaitlyn S. VanceDonald Philip BreakwellSandra HopeJulianne House Grose
Julianne House GroseDonald Philip BreakwellSandra Hope
Brittany J. KartchnerJonathan T. KiserChristopher D. KiserS. Wade McDanielMary Ann TaylorJoshua FisherBryce LuntSandra HopeJulianne House GroseDonald Philip Breakwell
Kyle CB SmithSandra HopeJulianne House GroseDonald Philip Breakwell
Alicia K. BrightonKaitlyn S. VanceKyle R. Jackson Merridee ParkerRyan P. SteckWilson R. OrmsbyMary Ann TaylorJoshua FisherBryce LuntSandra HopeJulianne House GroseDonald Philip Breakwell
Jordan CB KitchenAlicia K BrightonKylie M ChapmanBreeanna BakerMary Ann TaylorJoshua FisherBryce LuntSandra HopeJulianne House GroseDonald Philip Breakwell
E. Zane BarrusMarshall G. SheideMary Ann TaylorJoshua FisherBryce LuntSandra HopeJulianne House GroseDonald Philip Breakwell
Kylie M. ChapmanBreeanna BakerEmily A. DrakeJordan KitchenMary Ann TaylorJoshua FisherBryce LuntSandra HopeJulianne House GroseDonald Philip Breakwell