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Kim O'Neill

Professor
Microbiology & Molecular Biology

3142 LSB
Provo, UT 84602

Biography

B.Sc University of Ulster
D.Phil University of Ulster from the Biomedical Sciences Research Center focus Oncology
Arrived at BYU 1992. Published 100+ pier reviewed papers over 600 presentations. mentored over 900 undergraduates in research. 14 patents.

Research Interests

Our Lab focuses on three main aspects of cancer research:
1. Prevention through education.
Our laboratory focuses on the benefits that can be obtained through a diet rich in fruit and vegetables. We are investigating the many different plant chemicals that are involved in reducing cancer risk. We are studying phytochemicals at the molecular level to establish the mechanisms of protection. Current studies involve gene expression by certain phytochemicals, the effect of certain phytochemicals on DNA repair and immune function enhancement. We promote education by publishing our research findings in scientific journals, giving presentations at conferences and authoring chapters in scientific books.

2. Enhancing the body’s own defense systems, particularly the immune system and DNA repair mechanisms. The body has natural defenses against cancer. We study the immune system and help with the development of possible vaccines that could be used against certain forms of cancer. We are currently studying the interface between the immune system and the cancer cell, focusing on tumor associated macrophages and their role in the cancer process. We have developed new methods to study angiogenesis and metastasis. Currently we are investigating the immune response to tumor cell microenvironment and see the effect on macrophages when placed in different tumor micro-environments. We have also developed the DNA repair assays that allow the measurement of certain cells repair capacity which aid in studies of apoptosis and DNA repair. Understanding how we can enhance the immune system’s ability to recognize cancer cells will play a major role in the fight against cancer. We are also studying how the disease spreads or how metastasis occurs at the molec¬ular level, including the development of essential blood vessels to allow the tumor to grow. We are currently working with macrophages to elucidate their role in cancer development. We also are developing CAR technology by genetically engineering T cells to be used as a cancer therapeutic.

3. Early detection of disease. Cancer is generally easier to treat, and a better outcome is assured, if the tumor growth is found early in its development, before metastatic spread. We have discovered a tumor marker found in serum that will aid in diagnosis, prognosis and tumor management. This maker accurately reflects tumor presence, and tumor stage. Several other laboratories working in this field have confirmed this research. We have developed and accurate test method for this marker, BYU has patented the discovery, and it has been licensed to a biotech company for commercial development.

Teaching Interests

Immunology and Molecular Biology

Honors and Awards

  • Alumni Professorship Award, BYU Alumni Association (2016 - 2019)

Memberships

  • American Association for Cancer Research (1992 - Present)

Professional Citizenship

  • Board Member, American Association for Cancer Research (2015 - 2021)
  • Committee/Council Member, American Association for Cancer Research (2015 - 2021)
  • Committee/Council Member, American association for Cancer Research (2014 - 2016)

Courses Taught

Publications

Eliza E Bitter Michelle H Townsend Rachel Erickson Carolyn Allen Kim Leslie O'Neill Kim Leslie O'Neill Evita G Weagel Wei Meng Michelle Townsend Edwin J Velazquez Rachel A Brog Michael W Boyer Kelly Scott Weber Richard A Robison M H Townsend C J Peck W Meng Matthew J Heaton R A Robison Kim Leslie O'Neill E. G. Weagel W. Meng M. H. Townsend E. Velazquez-Espinoza Rachel Anne Brog Kelly Scott Weber Richard A Robison K. L. O’Neill Michelle Townsend Abigail M Felsted Stephen R Piccolo Richard A Robison Kim Leslie O'Neill Michelle H Townsend Michael D Anderson Evita G Weagel Edwin J Velazquez Kelly Scott Weber Richard A Robison Kim Leslie O'Neill Ryan Steck Spencer Hill Evita Weigel Kelly Scott Weber Richard A Robison Kim Leslie O'Neill Evita Weagel Curren Smith Pinggou Liu Richard A Robison Kim Leslie O'Neill Gajendra Shrestha Larry Lee StClair Kim Leslie O'Neill Gajendra Shrestha A. M. El-Naggar Larry Lee StClair Kim Leslie O'Neill Chris Hamilton Lucas Aidukaitis Pinggou Liu Richard A Robison Kim Leslie O'Neill Adrianne B Clifford Atif M Elnaggar Richard A Robison Kim Leslie O'Neill Chin-Woan Lowe Jordon K March Annette J Bunnell Kim Leslie O'Neill Richard A Robison Andrew R Garrett Gaytri Gupta Elera Mary A Keller Richard A Robison Kim Leslie O'Neill Richard A Robison Kim Leslie O'Neill Richard A Robison Jordon K March Marissa N Cohen James M Lindsey D A Millar Chinn-Woan Lowe Annette J Bunnell G Bruce Schaalje Kim Leslie O'Neill Richard A Robison Mark K Gunnell Charity D Lovelace Benjamin A Satterfield Emily A Moore Kim Leslie O'Neill Gayti Gupta-Elera Andrew Garrett Andres Martinez Ryan Kraus Richard A Robison Kim Leslie O'Neill Melissa Alegre Richard A Robison Kim Leslie O'Neill Melissa M Alegre Richard A Robison Kim Leslie O'Neill Gaytri Gupta Andrew Garrett Richard A Robison Kim Leslie O'Neill Benjamin A Satterfield Alvin F Stewart Cynthia S Lew David O Pickett Marissa Cohen Emily A Moore Patrick F Luedtke Kim Leslie O'Neill Richard A Robison William G Pitt Ghaleb Adnan Husseini R. I. El-Fayoumi Kim Leslie O'Neill N. Y. Rapoport

Presentations

Edwin J Velazquez Tyler B Humphreys Jordan D Cress David M Bellini Kathryn R Smith Kim Leslie O'Neill
Jordan D Cress Edwin J Velazquez Kathryn A Smith Taylor D Brindley Gadu Shrestha Reid A Robison Kim Leslie O'Neill
Edwin J Velazquez Jordan D Cress Kathryn A Smith Jonny R Skismore Tyler B Humphreys David M Bellini Zachery D Ewell Richard A Robison Kim Leslie O'Neill
Edwin J Velazquez Jordan D Cress Kathryn Smith Jonny R Skidmore Tyler B Humphreys Michelle H Townsend Zachery D Ewell Reid A Robison Kim Leslie O'Neill
Edwin J Velazquez Taylor D Brindley Gajendra Shrestha Richard A Skabelund Corbin M Lee Zach D Ewell Eliza E Bitter Michelle H Townsend Kelsey B Bennion Kai L Ong Kiara V Whitley Kelly Scott Weber Richard A Robison Kim Leslie O'Neill
Michelle H Townsend Zachary D Ewell Claudia M Tellez Freitas Dallas J Larsen Eliza L Lawerence Kelsey B Bennion Stephen R Piccolo Kelly S Weber Richard A Robison Kim Leslie O'Neill
Michelle H Townsend Kelsey Bennion Evita G Weagel Kiara Whitley Edwin Velazquez Kelly Scott Weber Kim Leslie O'Neill
Michelle H Townsend Abigail M Felsted Zac Ence Stephen R Piccolo Richard A Robison Kim ONeill
Michelle H Townsend Taylor P Cox Abigail M Felsted John E Lattin ZAc Ence Richard A Robison Stephen R Piccolo Kim ONeill
Kim Leslie O'Neill
Michelle H Townsend Zac E Ence Taylor P Cox John E Lattin Weston Burrup Stephen R Piccolo Richard A Robison Kim Leslie O'Neill
Michelle H Townsend Thomas Clay Abigail M Felsted Weston Burrup Evita G Weagel Edwin J Velazquez Kelly Scott Weber Reid A Robison Kim Leslie O'Neill
Kim ONeill Michelle H Townsend
Michelle H Townsend Abigail M Felsted Taylor P Cox Zac E Ence John E Lattin Michael K Boyer Stephen R Piccolo Richard A Robison Kim Leslie O'Neill
Michelle H. Townsend Abigail Felsted Evita G. Weagel Edwin J. Velazquez Richard A. Robison Kim ONeill
Connor J. Peck Michelle H. Townsend Kim Leslie O'Neill
Michelle H. Townsend Michael D. Anderson Evita G. Weagel Edwin J. Velazquez K. Scott Weber Richard A. Robison Kim Leslie O'Neill
E. G. Weagel M. H. Townsend M. D. Anderson E. J. Velazquez Kelly Scott Weber Richard A Robison K. L. O’Neill
Michelle H. Townsend Abi M. Felsted Jacob Clarke Richard A. Robison Kim Leslie O'Neill
Michelle H. Townsend Weston Burrup Evita Weagel Abigail Felsted Michael D. Anderson Edwin J. Velazquez K. Scott Weber Richard A. Robison Kim Leslie O'Neill
Connor J. Peck Michelle H. Townsend Kim Leslie O'Neill
Michelle Townsend Taylor D Brindley Abigail Felsted Evita Weagel Edwin J Velazquez Richard A Robison Kim Leslie O'Neill
Michelle Townsend Eric Olsen Abigail Felsted Richard A Robison Kim Leslie O'Neill
Michelle Townsend Eric Olsen Abigail Felsted Richard A Robison Kim Leslie O'Neill
M. H. Townsend J. E. Lattin M. D. Anderson AM Felsted E. Weagel E. Velasquez R. Robison Kim Leslie O'Neill
Edwin Velazquez Zachary Ewell Jake Lattin Kiara Vaden Michelle H Townsend Kelly Scott Weber Richard A Robison Kim Leslie O'Neill
Larry Lee StClair Shrestha Gajendra Leavitt Steven D. Kim Leslie O'Neill
Trevor Memmott Evita Weagel Justin Livingstone Pinggou Liu Atif Elnaggar Richard A Robison Kim Leslie O'Neill
Gadu Shrestha, Atif Elnaggar Michael Boswell Sean Derenthal Evita Weagel Larry Lee StClair Richard A Robison Kim Leslie O'Neill
Ryan Steck Mathew Wells Atif Elnaggar Kim Leslie O'Neill
Albert V Helsing Philip Lynch Michael Xiao Madison Ramsden Fabrizio Alegre Evita Weagel Atif Elnaggar James McCoy Richard A Robison Kim Leslie O'Neill
Gadu Shrestha, Atif Elnaggar Michael Boswell Sean Dereenthal Evita Weagel Larry Lee StClair Richard A Robison Kim Leslie O'Neill
Evita Weagel Andres Martinez Atif Elnaggar Sean Ellis Pinggou Liu Richard A Robison Kim Leslie O'Neill
Michael Xiao Atif Elnaggar Albert Helsing Philip Lynch Melissa Alegre Richard A Robison Kim Leslie O'Neill
Ryan Steck Mathew Wells Pinggou Liu Atif ELnaggar Kim Leslie O'Neill
Albert Hesling Atif Elnaggar Philip Lynch Michael Xiao Madison Ramsden Fabrizio Alegre Evita Weagel James McCoy Richard A Robison Kim Leslie O'Neill
Kim Leslie O'Neill Justin Livingstone Eugene Lee Sam Barlow Atif ELnaggar Evita Weagel Pinggou Liu Richard A Robison
Kim Leslie O'Neill Atif Elnaggar Amy Clement Richard A Robison
Kim Leslie O'Neill Ryan Kraus Andres Martinez Kylie Measom Matt Gill Gaytri Gupta-Elera Andrew Garrett Richard A Robison
Kim Leslie O'Neill Atif Elnaggar Adam Chavez Ellen Peterson Rani Kuttab Richard A Robison
Kim Leslie O'Neill Melissa Alegre Britt Germann Michael Leavitt D Eggett N Killpack Sean Burton A Orton C Leavitt
Kim Leslie O'Neill Kylie Measom Andres Martinez Erin Sharp Timothy Michaelis
Kim Leslie O'Neill James McCoy Adam Grooms Joshua Emerson Ryan Kraus Andres Martinez Atif Elnaggar
Kim Leslie O'Neill Kylie Measom Andres Martinez Erin Sharp Timothy C Michaelis
Nathan R Jensen Kim Leslie O'Neill Richard A Robison
Jordan M Meyers E Ryndock M J Conway Craig M Meyers Kim Leslie O'Neill Richard A Robison
Teri M Bills Quin C Shepherd Annette J Blam Emily A Moore John S Gardner G Bruce Schaalje Kim Leslie O'Neill Richard A Robison
Jordan M Meyers E Ryndock M J Conway Kim Leslie O'Neill Craig M Meyers Richard A Robison
Teri M Bills Quin C Shepherd Annette J Blam Emily A Moore John S Gardner G Bruce Schaalje Kim Leslie O'Neill Richard A Robison
Mark K Gunnell C D Carter W S Jonas Benjamin A Satterfield Emily A Moore Kim Leslie O'Neill Richard A Robison
Mark K Gunnell C D Carter W S Jonas Benjamin A Satterfield Emily A Moore Kim Leslie O'Neill Richard A Robison
Kim O'Neill