Dr. Hyldahl is an associate professor of Exercise Sciences. He received his Bachelor’s degree in Athletic Training from the University of Utah, and his PhD in Kinesiology from the University of Massachusetts Amherst. His laboratory studies the cellular and molecular mechanisms of skeletal muscle in response to injury and disuse, with emphasis on the effect of aging on these processes. Most recently, his laboratory has been involved in a series of studies to determine how repeated exposure to heat stress can result in skeletal muscle adaptation, and can mitigate the deleterious effects of limb disuse on muscle and vascular function. The primary goal of his research is to hopefully develop effective clinical interventions to enhance muscle function in the face of injury and aging.
Research InterestsSkeletal muscle is an enormous, fascinating, and spectacularly adaptive organ system, whose vitality has an enormous impact on human health and well-being. Though appreciated most widely for its role in human motor activity, skeletal muscle accounts for over 50% of whole body protein metabolism, 80% of glucose disposal, and is emerging as an exquisitely important endocrine organ. Importantly, epidemiological data have shown quite clearly that reduced skeletal muscle mass and function have widespread deleterious effects on human health including frailty, metabolic dysfunction and mortality. Accordingly, the overarching goal of my laboratory is to contribute in a meaningful way to the development of crucial and much-needed clinical interventions to maintain skeletal muscle vitality through the lifespan by studying the biologic mechanisms that underlie muscle adaptation to stress (e.g. disuse, damage, exercise and injury) in healthy, aged or clinical populations. To achieve this goal, we strive primarily to undertake studies in human skeletal muscle through innovative and novel approaches, supplementing, where appropriate, with mechanistic experiments in relevant animal and in vitro models. Of particular interest are: 1) The role of extracellular matrix remodeling in muscle repair and adaptation to exercise; 2) The effect of externally applied modalities (e.g., heat/cold stress, massage etc.) on muscle metabolic and regenerative function, and their potential as therapeutic interventions; and 3) How inflammation and inflammatory related intracellular signaling affects muscle adaptation and reparative outcomes following exercise and/or injury.
- Ph.D., Kinesiology , University of Massachusetts Amherst (2011)
- M.S., Kinesiology , University of Massachusetts Amherst (2008)
- B.S., Exercise Science , Athletic Training, University of Utah (2003)
Licenses and Certifications
- National Athletic Trainers Association (2002 - Present)