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Sandra Hope

Teaching Professor
Microbiology & Molecular Biology

3134 LSB
Provo, UT 84602

Biography
At Utah State University, I received my undergraduate degree in German while studying pre-veterinary medicine.  I then completed a Master’s Degree at Utah State University in BioVeterinary Science with research on anti-viral drugs.  At the University of Kentucky, I obtained a PhD in Veterinary science, with emphasis on virology and molecular immunology in horses.  My post-doctoral research was in immunology at the University of Kentucky Chandler Medical School where I developed the first transgenic inducible macrophage knockout mouse model.  I joined BYU in 2004.  I am currently pursuing a business degree in the BYU Marriot School Executive MBA program and anticipate earning that degree in 2021.

Teaching Interests
I enjoy teaching in the lecture and lab settings, and in one-on-one or small group teaching for research.  As the director of the Research Instrumentation Core facility, I work with students to use research equipment, refine research protocols, and interpret research data.  As a teaching professor, I teach Immunology lecture and lab, Infection & Immunity (which includes virology, immunology, and bacteriology), and Biology classes.

Research Interests
In the Research Instrumentation Core facility, I collaborate or advise on diverse applications for Flow Cytometry.  I have lead or collaborated on projects ranging from phage treatment of a bacterial infection in honeybees to nanotechnology applications for DNA delivery into cells and production of transgenic animals.  My current research interest centers on business practices and technology transfer from the sciences into industry, which is why I am currently in the Executive MBA program.

Education
University of Kentucky, Vet Science, Ph.D. (2000)
Utah State University, Vet Science, M.S. (1993)
Utah State University, German, B.Sc. (1992)

Administrative Positions
Director of the Research Instrumentation Core Facility (RIC)

The RIC is a College of Life Sciences facility hosted by the Microbiology and Molecular Biology Department. The RIC houses a FACSCanto flow cytometer, gel imager, plate reader, NanoDrop spectrophotometer, mini fluorimeter, high speed centrifuge, cytospin centrifuge and a Zeiss fluorescent microscope. The RIC has the following goals:

1. Procure and maintain high quality research equipment: improve access to and use of high quality research equipment, maintain quality instruments, and procure quality instruments not otherwise attainable for an individual lab.
2. Provide sample processing services and technical support through technical support for general use equipment in the facility, services for sample processing on technically complex equipment, and interpretation of generated data.
3. Provide training and promote the use of available research equipment by training users on the use of research equipment and interpretation of data, and promoting the use of research equipment.

Duties of the director include the above three goals and regular duties for facility operations such as purchasing supplies; overseeing equipment maintenance; advising students and faculty about RIC equipment capabilities, protocols and data analysis assistance; managing accounts; and supervising the work of the laboratory technician.

Honors and Awards
Brigham Young University : Outstanding Achievement in Technology Transfer

Publications

Journal Articles

Stamereilers C, Fajardo CP, Walker JK, Mendez KN, Castro-Nallar E, Grose JH, Grose JH, Hope S, Tsourkas PK. 2018. Genomic Analysis of 48 Paenibacillus larvae Bacteriophages. Viruses. 10(7).

Sessions JW, Armstrong DG, Hope S, Jensen BD. 2017. A Review of Genetic Engineering Biotechnologies for Enhanced Chronic Wound Healing. Experimental Dermatology.

Berg JA, Merrill BD, Crockett JT JT, Esplin KP, Evans MR, Heaton KE, Hilton JA, Hyde JR, McBride MS, Schouten JT, et al. 2016. Characterization of Five Novel Brevibacillus Bacteriophages and Genomic Comparison of Brevibacillus Phages. PLoS One. 1(6):e015683.

Sessions JW, Hanks BW, Lindstrom DL, Hope S, Jensen BD. 2016. Transient Low Temperature Effects on Propidium Iodide Uptake in Lance Array Nanoinjected HeLa Cells. Journal of Nanotechnology in Engineering and Medicine. 6:041005.

Grose JH, Belnap DM, Jensen JD, Mathis AD, Prince JT, Merrill BD, Hope S, Breakwell DP. 2014. The Genomes, Proteomes, and Structures of Three Novel Phages That Infect the Bacillus cereus Group and Carry Putative Virulence Factors. Journal of Virology. 88:11846-11860.

Grose JH, Jensen GS, Hope S, Breakwell DP. 2014. Genomic comparison of 93 Bacillus phages reveals 12 clusters, 14 singletons and remarkable diversity. 15:855.

Merrill BD, Grose JH, Breakwell DP, Hope S. 2014. Characterization of Paenibacillus larvae bacteriophages and their genomic relationships to firmicute bacteriophages. BMC Genomics. 15(Aug 30):745.

Jordan TC, Hope S, Carson S, Caruso SM, Clase K, DeJong RJ, Dennehy JJ, Denver DR, Dunbar D, Elgin SR, et al. 2014. A broadly implementable research course for first-year undergraduate students. mBio. 5(1):8.

Grose JH, Jensen JD, Merrill BD, Fisher J, Hope S, Breakwell DP. 2014. The Genomes of Three Novel Bacillus cereus Bacteriophages. Genome Announcements. 2(1):2.

Burnett WJ, Lee CJ, Merrill BD, Hope S. 2013. Utah's Red Honey. Bee Culture. Nov.:37-39.

Breakwell DP, Barrus EZ, Benedict AB, Brighton AK, Fisher JN, Gardner AV, Kartchner BJ, Ladle KC, Lunt BL, Merrill BD, et al. 2013. Genome Sequences of Five Cluster B1 Mycobacteriophages. Genome Announcements. 1(6).

Sheflo MA, Gardner AV, Merrill BD, Fisher JN, Lunt BL, Breakwell DP, Grose JH, Hope S. 2013. Complete Genome Sequences of Five Paenibacillus larvae Bacteriophages. Genome Announcements. 1(6).

Hope S, Jensen BD. 2013. Nanotechnology for genetic engineering in agriculture. ISB News Report Agricultural and Environmental Biotechnology. June:5-8.

Smith KC, Castro-Nallar E, Fisher JN, Breakwell DP, Grose JH, Hope S. 2013. Phage cluster relationships identified through single gene analysis. BMC Genomics. 14(410):15.

Wilson AM, Aten QT, Toone NC, Black JL, Jensen BD, Tamowski S, Howell LL, Hope S. 2013. Transgene Delivery via Intracellular Electroporetic Nanoinjection. Transgenic Research. 22(5):993-1002.

Aten QT, Jensen BD, Susan T, Wilson AM, Howell LL, Hope S. 2012. Nanoinjection: Pronuclear DNA Delivery using a Charged Lance. Transgenic Research. 21(6):1279-1290.

Hatfull G, Grose JH, Hope S, Breakwell DP. 2012. Complete genome sequences of 138 mycobacteriophages. Journal of Virology. 86(4):2382-2384.

Other

Earley BJ, Engle JM, Smith KC, Lunt BL, Fisher JN, Payne II DE, Breakwell DP, Hope S, Grose JH. 2011. Mycobacterium phage Jebeks, complete genome. JN572061st ed.

Presentations

Fajardo C, Meredith S, Roll C, Griffitts JS, Hope S, Grose JH, Breakwell DP. Proof of Concept: Determining Phage Adsorption Using Flow Cytometry. Intermountain ASM TriBranch Meeting. Durango, CO. 2018.

Hope S, Sessions J, Skousen C, Garcia B, Price K, Hanks B, Alder JK, Jensen BD. Microfabricated Lance Array Nanoinjection system delivers CRISPR-Cas9 to hundreds of thousands of cells simultaneously. International Transgenic Technologies Society 13th Conference. Prague, Czech Republic. 2016.

Brighton AK, Fisher J, Lunt BL, Taylor MA, Smith KC, Breeanna Baker EB, Chapman KM, Drake EA, Jackson KR, Kartchner BJ, et al. Additional Evidence for Frameshifts in A2 and Gene Mosaicism in F Mycobacteriophage. Science Education Alliance (SEA) Annual Symposia. Janelia Farm, Ashburn, VA. 2011.

Grose JH, Breakwell DP, Hope S. Out of the SEA: Getting Students to Crawl on Land. Science Education Alliance (SEA) Annual Symposia. Janelia Farm, Ashburn, VA. 2011.

Kartchner BJ, Kiser JT, Kiser CD, Wade McDaniel S, Taylor MA, Fisher J, Lunt B, Hope S, Grose JH, Breakwell DP. Clustering of Mycobacteriophage in the Utah Landscape. ASM Intermountain Branch Meeting. Weber State University. 2011.

Smith KC, Hope S, Grose JH, Breakwell DP. Degenerate PCR Primers to Identify Mycobacteriophage Clusters and Sub-Clusters. ASM Intermountain Branch Meeting. Weber State University. 2011.

Brighton AK, Vance KS, Merridee Parker KJ, Steck RP, Ormsby WR, Taylor MA, Fisher J, Lunt B, Hope S, Grose JH, et al. Gene Mosaicism Demonstrated in Mycobacteriophage Shauna1. ASM Intermountain Branch Meeting. Weber State University. 2011.

Kitchen JC, Brighton AK, Chapman KM, Baker B, Taylor MA, Fisher J, Lunt B, Hope S, Grose JH, Breakwell DP. Morphological Traits of Mycobacteriophage Clusters and Sub-Clusters. ASM Intermountain Branch Meeting. Weber State University. 2011.

Zane Barrus E, Sheide MG, Taylor MA, Fisher J, Lunt B, Hope S, Grose JH, Breakwell DP. Shauna1 Mycobacteriaphage holin gene confirms common ancestry of all F cluster phage. ASM Intermountain Branch Meeting. Weber State University. 2011.

Chapman KM, Baker B, Drake EA, Kitchen J, Taylor MA, Fisher J, Lunt B, Hope S, Grose JH, Breakwell DP. TA17A: A Unique Member of the Mycobacteriophage Sub-Cluster A2. ASM Intermountain Branch Meeting. Weber State University. 2011.