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Scott Weber

Associate Professor
Microbiology & Molecular Biology

3137 LSB
Provo, UT 84602

Biography
I am an Associate Professor in the Department of Microbiology and Molecular Biology at BYU. My research is centered on improving the immune system response to infectious disease, asthma, and cancer. I teach Advanced Molecular Biology, Immunology and Flow Cytometry courses.

Previously I was an Instructor and Postdoctoral Fellow at Washington University School of Medicine in St. Louis. I earned my Ph.D. from the University of Illinois and my undergraduate and masters degrees are from Brigham Young University.

Teaching Interests
Immunology, Molecular Biology, Flow Cytometry

Research Interests
T cells play a critical role in protection from infectious disease, cancer, Alzheimer's disease, and asthma. Helper T cells coordinate the adaptive and innate immune responses and deliver essential survival signals for the generation of cytotoxic memory T cells, antibody responses, and protective immunity. A better understanding of T cell activation and memory formation may enable improvement of infectious disease vaccines, help with the discovery of cancer treatments, and decrease Alzheimer's disease and asthma development.

The main areas of research in the Weber Lab are: 1) Understanding the molecular basis of T cell activation and improving the T cell memory response to infectious disease 2) Engineering improved immunological proteins to combat cancer 3) Determining the involvement of the immune system in Alzheimer's disease and 4) Understanding how environmental exposures influences asthma development.

Education
University of Illinois, Cell and Structural Biology (Molecular Immunology focus), Ph.D. (2005)
Brigham Young University, Zoology (Neuroendocrinology focus), M.S. (2000)
Brigham Young University, Zoology (Human Biology focus), B.Sc. (1998)

Honors and Awards
BYU College of Life Sciences: Outstanding Research Award
BYU Department of Microbiology and Molecular Biology: Research Award

Publications

Freitas C, Johnson D, Weber KS. 2018. T cell calcium signaling regulation by the CD5 co-receptor. International Journal of Molecular Sciences. 19(5):1295: 21.

Weber KS, Bridgewater LC, Jensen JL, Breakwell DP, Nielsen B, Johnson SM. 2018. Personal microbiome analysis improves student engagement and interest in Immunology, Molecular Biology, and Genomics undergraduate courses. PLoS One. 13(4):20 pages.

Johnston JD, Kruman B, Nelson M, Merrill RM, Graul R, Hoybjerg T, Tuttle S, Myers S, Cook R, Weber KS. 2017. Differential effects of air conditioning type on residential endotoxin levels in a semi-arid climate. Indoor Air. 1-9.

Johnston JD, Barney T, Crandall J, Brown M, Westover T, Paulson S, Smith M, Weber KS. 2017. Prevalence of dust mite allergens in low-income homes with evaporative coolers in a semi-arid climate. Archives of Environmental and Occupational Health. 73(1):38-41.

Johnston JD, Tuttle SC, Nelson MC, Bradshaw RK, Hoybjerg TG, Johnson JB, Kruman BA, Orton TS, Cook RB, Eggett DL, et al. 2016. Evaporative Cooler Use Influences Temporal Indoor Relative Humidity but not Dust Mite Allergen Levels in Homes in a Semi-arid Climate. PLOS ONE. 11(1).

Steck R, Hill S, Weigel E, Weber KS, Robison RA, O'Neill KL. 2015. Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine. Pharmacology Research & Perspectives. 3(6).

Persuad SP, Parker CR, Weber KS, Allen PM. 2014. Intrinsic CD4+ T cell sensitivity and response to pathogen are set and sustained by avidity for thymic and peripheral self-pMHC. Nature Immunology.

Lynch JN, Donermeyer DL, Weber KS, Kranz DM, Allen PM. 2013. Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells. Molecular Immunology. 53(3):283-294.

Graw F, Weber KS, Allen PM, Perelson AS. 2012. Dynamics of CD4+ T Cell Responses against Listeria monocytogenes. Journal of Immunology. 189(11):5250-5256.

Weber KS, Li QJ, Persaud SP, Campbell JD, Davis MD, Allen PM. 2012. Distinct populations of CD4+ helper T cells mediate CD4+ and CD8+ memory responses to infection. Proceedings of the National Academy of Sciences. U S A. 109(24):9511-9516.

Weber KS, Hildner K, Murphy KM, Allen PM. 2010. Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. Journal of Immunology. 185(5):2836-2846.

Persaud SP, Donermeyer DL, Weber KS, Kranz DM, Allen PM. 2010. High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics. Molecular Immunology. 47(9):1793-801.

Morley SC, Weber KS, Kao H, Allen PM. 2008. Protein kinase C-θ is required for efficient positive selection. Journal of Immunology. 180(3):1442-1450.

Weber KS, Miller MJ, Allen PM. 2008. Th17 cells exhibit a distinct calcium profile from Th1 and Th2 cells and have Th1-like motility and NFAT nuclear localization. Journal of Immunology. 180(3):1442-1450.

Donermeyer DL, Weber KS, Kranz DM, Allen PM. 2006. The study of high affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy. Journal of Immunology. 177(10):6911-6919.

Richman SA, Healan SJ, Weber KS, Donermeyer DL, Dossett ML, Greenberg PD, Allen PM, Kranz DM. 2006. Development of a novel strategy for engineering high-affinity proteins by yeast display. Protein Engineering, Design, and Selection. 19(6):255-264.

Weber KS, Donermeyer DL, Allen PM, Kranz DM. 2005. Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proceedings of the National Academy of Sciences. U S A. 102(52):19033-19038.

Lephart ED, West TW, Weber KS, Rhees RW, Setchell KD, Adlercreutz H, Lund TD. 2002. Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicology and Teratology. 24, 5-16.

Roper RJ, Weis JJ, McCracken BA, Green CB, Ma Y, Weber KS, Fairbairn D, Butterfield RJ, Potter MR, Zachary JF, et al. 2001. Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes and Immunity. 2, 388-397.

Weber KS, Setchell KD, Stocco DM, Lephart ED. 2001. Dietary soy-phytoestrogens decrease testosterone levels and prostate weight, without altering LH, prostate 5α-reductase or testicular StAR levels in adult male Sprague-Dawley rats. Journal of Endocrinology. 170, 591-599.

Weber KS, Setchell KD, Lephart ED. 2001. Maternal and perinatal brain aromatase: Effects of dietary soy phytoestrogens. Developmental Brain Research. 126, 217-221.

Lephart ED, Call SB, Rhees RW, Jacobson NA, Weber KS, Bledsoe J, Teuscher C. 2001. Neuroendocrine regulation of sexually dimorphic brain structure and associated sexual behavior in male rats is genetically controlled. Biology of Reproduction. 64, 571-578.

Lephart ED, Thompson JM, Setchell KD, Adlercreutz H, Weber KS. 2000. Phytoestrogens decrease brain calcium binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Brain Research. 859, 123-131.

Weber KS, Jacobson NA, Setchell KD, Lephart ED. 1999. Brain aromatase and 5 alpha reductase, regulatory behaviors and testosterone levels in adult rats on phytoestrogen diets. Proceedings of the Society for Experimental Biology and Medicine. 221(2), 131-135.

Stone JD, Yin Y, Mo M, Weber KS, Donermeyer DL, Allen PM, Mariuzza RA, Kranz DM. 2012. Engineering High-Affinity T Cell Receptor/ Cytokine Fusions for Therapeutic Targeting, Protein Engineering. , editor. InTech. p. ISBN: 978-953-51-0037-9