Zachary Funk (EXCS ‘25) is conducting research that could lead to exciting advancements in the medical field. In the Thomson Lab—where the focus is on creating pharmaceuticals to aid muscle regeneration—Funk is investigating the potential of AMPK, an enzyme that regulates cellular metabolism, as a target for improving muscle regulation. The current goal of the lab is to develop a treatment for muscle wasting disorders, a breakthrough that could improve quality of life for countless individuals.
An AMPK pharmaceutical could be taken alongside chemotherapy to help counteract the muscle loss often seen in cancer patients due to cachexia, a common complication of chronic diseases like cancer. This condition leads to severe loss of muscle and fat, making patients increasingly frail. Discovering a method to increase muscle regeneration during chemotherapy could allow patients to endure more rounds of treatment, thereby increasing its overall effectiveness.
Examining Muscle Regeneration in Mice
Funk’s study explored the effects of 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) on muscle regeneration in a cachexia model. He hypothesized that AICAR, a compound known to activate the enzyme AMPK, would stimulate muscle regeneration and help counteract the effects of the condition. The experiment showed that mice treated with AICAR had a higher percentage of large muscle fibers compared to those given saline, indicating faster regeneration. These results suggest that AICAR significantly enhances muscle repair six days after injury. However, since AICAR is only potent in mice, Funk believes future research should focus on finding an AMPK activator compatible with humans to achieve similar regenerative effects.
Reflecting on his research journey, Funk realized not only how his faith influenced his work but also how his work strengthened his faith. “Diving deeper into the physiology of the human body—the way proteins are expressed, the different pathways and feedback signals—it’s insane how intricate the human body is,” Funk shares. “It’s been a testimony to me that there’s no way that intricacy comes from chance. God made us. Regardless of the pathway, God was the one directing it. That is of no doubt to me.”
Looking ahead, Funk plans to pursue orthopedic surgery. His experiences in the lab have not only deepened his understanding of human physiology but also instilled in him the discipline, curiosity, and faith-driven perspective that will guide his journey in medicine and beyond.