Jason Kenealey

Biography

Dr. Jason Kenealey graduated from Brigham Young University in 2005 with a B.S. in biochemistry and a minor in business. Dr. Kenealey completed his dissertation in the laboratory of Dr. Arthur S. Polans and received his PhD from the University of Wisconsin-Madison in 2011. Dr. Kenealey continued his training as a post doctoral fellow at the National Institutes of Health in the Laboratory of Dr. S. Patricia Becerra. Dr. Kenealey now lives in Orem with his wife and four children.

Research Interests

Nature provides a diverse and copious library of chemical structures. These naturally occurring molecules have been utilized as therapeutics for thousands of years. The importance of natural products continues to be apparent in medicine today as roughly 70% of FDA approved drugs are natural products or close derivatives.

My lab's objective is to further utilizes the natural chemical library by (1) identifying natural compounds with chemotherapeutic activity, (2) elucidating the molecular mechanism of these compounds, and (3) determining the structural elements in the molecule that confer the anti-cancer activity. To achieve these objectives my lab uses a combination of live-cell imaging and biochemical approaches.

Memberships

BYU Cancer Research Center, 2014-Present

Courses Taught

Winter 2019

NDFS 200: Nutrient Metabolism Section 001
NDFS 434: Nutr Bio-organic Chemistry Section 001
NDFS 494R: Undergrad Research in N D F S Section 009
NDFS 602: Advanced Human Nutrition 2 Section 002
NDFS 699R: Master's Thesis Section 002

Fall 2018

NDFS 200: Nutrient Metabolism Section 001
NDFS 294: Nutrition Research Fundamentls Section 001
NDFS 399R: Acad Internship: Nutritnl Sci Section 006
NDFS 494R: Undergrad Research in N D F S Section 009
NDFS 699R: Master's Thesis Section 002

Spring 2018

LFSCI 199R: Nonresearch Academic Internshp Section 004
NDFS 200: Nutrient Metabolism Section 001
NDFS 494R: Undergrad Research in N D F S Section 008

Winter 2018

NDFS 434: Nutr Bio-organic Chemistry Section 001
NDFS 494R: Undergrad Research in N D F S Section 009
NDFS 602: Advanced Human Nutrition 2 Section 001

Publications

Journal Articles

Subramanian P, Locatelli-Hoops S, Kenealey JD, DesJardin J, Notari L, Becerra SP. 2013. Pigment Epithelium-derived Factor (PEDF) Prevents Retinal Cell Death via Pigment Epithelium-derived Factor-R (PEDF-R): Identification of a Functional Ligand Binding Site. The Journal of Biological Chemistry.

Johnson JL, Kenealey JD, Hilton RJ, Brosnahan D, Watt RK, Watt GD. 2011. Non-reductive iron release from horse spleen ferritin using desferoxamine chelation. Journal of Inorganic Biochemistry. 105(2):202-207.

Kenealey JD, Subramanian L, Van Ginkel PR, Darjatmoko S, Lindstrom MJ, Ghosh SK, Song Z, Hsung RP, Kwon GS, Eliceiri KW, et al. 2011. Resveratrol Metabolites Do Not Elicit Early Pro-apoptotic Mechanisms in Neuroblastoma Cells. J Agric Food Chem. 59(9):4979-4986.

Subramanian L, Youssef S, Bhattacharya S, Kenealey JD, Polans AS, van Ginkel PR. 2010. Resveratrol: challenges in translation to the clinic -- a critical discussion. Clin Cancer Res. 16(24):5942-5948.

Wilson PE, Nyborg AC, Kenealey JD, Lowery TJ, Crawford K, King CR, Engan AJ, Johnson JL, Watt GD. 2006. Evidence for a synergistic salt-protein interaction -- complex patterns of activation vs. inhibition of nitrogenase by salt. Biophys Chem. 122(3):184-194.

Book Chapter

Kenealey JD, Colley NJ, Polans AS. 2011. Calcium in Vision. Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov, editors. Encyclopedia of Metalloproteins. lllth ed. New York, New York: Springer Reference. vol. 10