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Juan Arroyo

Associate Professor
Physiology & Developmental Biology

3052 LSB
Provo, UT 84602


Ph.D., Southern Illinois University School of Medicine, 2003
Postdoctoral, Kansas University Medical Center, 2003-2004
Postdoctoral, University of Colorado Health Sciences Center, 2005-2009

Research Interests

Trophoblast cells are important for normal placental growth and development. Aberrant trophoblast functioning is associated with poor placentation influencing fetal health. The focus of our laboratory has been in the molecular signaling of trophoblast cells during apoptosis, hypoxia and the regulation of cell invasion during pregnancies complicated with Intrauterine Growth Restriction, Preterm Delivery and Preeclampsia. We are also interested in the role of the mTOR family of proteins in placental and trophoblast development, invasion and functioning across gestation during these diseases.

Courses Taught

Winter 2019

  • PDBIO 295R: Introductory Undgrad Research Section 001
  • PDBIO 450R: Readings & Discussion in PDBio Section 001
  • PDBIO 495R: Adv Undergraduate Research Section 001
  • PDBIO 498: Advanced Senior Research Section 001
  • PDBIO 649R: Laboratory Research Section 001

Fall 2018

  • PDBIO 120: Science of Biology Section 001
  • PDBIO 295R: Introductory Undgrad Research Section 001
  • PDBIO 450R: Readings & Discussion in PDBio Section 001
  • PDBIO 495R: Adv Undergraduate Research Section 001
  • PDBIO 562: Reproductive Physiology Section 001
  • PDBIO 601: Cell & Molecular Physiology Section 001
  • PDBIO 694R: Research Presentation Section 001

Summer 2018

  • PDBIO 495R: Adv Undgraduate Research Section 001

Spring 2018

  • PDBIO 495R: Adv Undgraduate Research Section 001


Journal Articles

Chapman S, Mick M, Hall P, Mejia C, Sue S, Wase BA, Nguyen MA, Whisenant EC, Wilcox SH, Winden DR, et al. 2018. Cigarette smoke extract induces oral squamous cell carcinoma cell invasion in a receptor for advanced glycation end-product-dependent manner. Eur J Oral Sci. 126(1):33-40.

Hirschi KM, Chapman S, Hall P, Ostergar A, Winden D, Reynolds PR, Arroyo JA. 2018. Gas6 protein induces invasion and reduces inflammatory cytokines in oral squamous cell carcinoma cells. J Oral Pathol Med. doi:10.1111/jop.12738

Lewis JB, Bodine JS, Gassman JR, Munoz SA, Milner DC, Dunaway DM, Egbert KM, Monson TD, Broberg DS, Arroyo JA, et al. 2018. Transgenic up-regulation of Claudin-6 decreases fine diesel particulate matter (DPM)-induced pulmonary inflammation. Environ Sci Pollut Res. 25(18):18179-88.

Lewis JB, Jimenez FR, Merrell BJ, Kimbler B, Arroyo JA, Reynolds PR. 2018. The expression profile of Claudin family members in the developing mouse lung and expression alterations resulting from exposure to secondhand smoke (SHS). Exp Lung Res. 44(1):13-24.

Lewis JB, Mejia C, Jordan C, Monson TD, Bodine JS, Dunaway TM, Egbert KM, Lewis AL, Wright TJ, Ogden KC, et al. 2017. Inhibition of the receptor for advanced glycation end-products (RAGE) protects from secondhand smoke (SHS)-induced intrauterine growth restriction (IUGR) in mice. Cell Tissue Research. doi:10.1007/s00441-017-2691-z

Monson T, Wright T, Galan HL, Reynolds PR, Arroyo JA. 2017. Caspase dependent and independent mechanisms of apoptosis across gestation in a sheep model of placental insufficiency and intrauterine growth restriction. Apoptosis. 22(5):710-718. doi:10.1007/s10495-017-1343-9

Sanders NT, Dutson DJ, Durrant JW, Lewis JB, Wilcox SH, Winden DR, Arroyo JA, Bikman BT, Reynolds PR. 2017. Cigarette smoke extract (CSE) induces RAGE-mediated inflammation in the Ca9-22 gingival carcinoma epithelial cell line. 80:95-100. doi:10.1016/j.archoralbio.2017.03.021

Lewis JB, Hirschi KM, Arroyo JA, Bikman BT, Kooyman DL, Reynolds PR. 2017. Plausible Roles for RAGE in Conditions Exacerbated by Direct and Indirect (Secondhand) Smoke Exposure. Int J Mol Sci. 18(3):E652. doi:10.3390/ijms18030652

Mejia C, Lewis J, Jordan C, Mejia J, Ogden C, Monson T, Winden D, Reynolds PR, Arroyo JA. 2016. Decreased activation of placental mTOR family members is associated with the induction of intrauterine growth restriction (IUGR) by secondhand smoke (SHS) in the mouse. Cell Tissue Research. 367(2):387-395. doi:10.1007/s00441-016-2496-5

Lee G, Price M, Mejia C, Galan H, Arroyo JA. 2014. Increased trophoblast expression of NFAT5/TonEBP in preeclamptic placentas and in hyperosmolar treated BeWo cells.

Arroyo JA, Garcia-Jones P, Battaglia F, Galan HL. 2012. Placental TonEBP/NFAT5 Osmolyte Regulation in an Ovine Model of Intrauterine Growth Restriction (IUGR). Biology of Reproduction. 86(3):94.

Park M, Galan HL, Arroyo JA. 2011. Effect of hypoxia on endothelial nitric oxide synthase, NO production, intracellular survival signaling (p-ERK1/2 and p-AKT) and apoptosis in human term trophoblast. American Journal of Reproductive immunology. 65(4):407-14.

Arroyo JA, Anthony RV, Parker TA, Galan HL. 2010. eNOS, NO, and the activation of ERK and AKT signaling at mid-gestation and near-term in an ovine model of intrauterine growth restriction. Systems Biology in Reproductive Medicine. 56(1):62-73.

Arroyo JA, Li C, Schlabritz-Loutsevitch N, McDonald T, Nathanielsz P, Galan HL. 2010. Increased placental XIAP and caspase 3 is associated with increased placental apoptosis in a baboon model of maternal nutrient reduction. American journal of Obstetrics and Gynecology. 203(4):364.

Arroyo JA, Brown L, Galan HL. 2009. Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction. American Journal of Obstetrics and Gynecology. 201(6):616.

Arroyo JA, Konno T, Khalili DC, Soares MJ. 2005. A simple in vivo approach to investigate invasive trophoblast cells. International journal of Developmental Biology. 49:977-80.


Liu B, Rose BJ, Weyand JA, Perez BR, Clark C, Hirschi K, Arroyo JA, Reynolds PR, Kooyman DL. 2018. Exposure to second-hand cigarette smoke exacerbates the progression of OA. Osteoarthritis and Cartilage. 26(S126):S126.

Book Review

Arroyo JA, Winn V. 2008. Vasculogenesis and angiogenesis in the IUGR placenta. 3rd ed. 172-7 p.

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